Oxidative Stress and Placental Pathogenesis: A Contemporary Overview of Potential Biomarkers and Emerging Therapeutics DOI Open Access

Ioana Vornic,

Victor Buciu,

Cristian Furău

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12195 - 12195

Published: Nov. 13, 2024

Oxidative stress (OS) plays a crucial role in placental pathogenesis and pregnancy-related complications. This review explores OS's impact on development function, focusing novel biomarkers for the early detection of at-risk pregnancies emerging therapeutic strategies. We analyzed recent research OS pathophysiology, examining its sources, mechanisms, effects. While trophoblast invasion under low-oxygen conditions hypoxia-induced regulate physiological development, excessive can lead to complications like miscarriage, preeclampsia, intrauterine growth restriction. Promising biomarkers, including malondialdehyde, 8-isoprostane, sFlt-1/PlGF ratio, show potential pregnancy Therapeutic strategies targeting OS, such as mitochondria-targeted antioxidants, Nrf2 activators, gasotransmitter therapies, demonstrate encouraging preclinical results. However, clinical translation remains challenging. Future should focus validating these large-scale studies developing personalized therapies modulate OS. Emerging approaches extracellular vesicle-based nanomedicine warrant further investigation both diagnostic applications Integrating with other molecular cellular markers offers improved identification pregnancies.

Language: Английский

Oxidative Stress and Placental Pathogenesis: A Contemporary Overview of Potential Biomarkers and Emerging Therapeutics DOI Open Access

Ioana Vornic,

Victor Buciu,

Cristian Furău

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12195 - 12195

Published: Nov. 13, 2024

Oxidative stress (OS) plays a crucial role in placental pathogenesis and pregnancy-related complications. This review explores OS's impact on development function, focusing novel biomarkers for the early detection of at-risk pregnancies emerging therapeutic strategies. We analyzed recent research OS pathophysiology, examining its sources, mechanisms, effects. While trophoblast invasion under low-oxygen conditions hypoxia-induced regulate physiological development, excessive can lead to complications like miscarriage, preeclampsia, intrauterine growth restriction. Promising biomarkers, including malondialdehyde, 8-isoprostane, sFlt-1/PlGF ratio, show potential pregnancy Therapeutic strategies targeting OS, such as mitochondria-targeted antioxidants, Nrf2 activators, gasotransmitter therapies, demonstrate encouraging preclinical results. However, clinical translation remains challenging. Future should focus validating these large-scale studies developing personalized therapies modulate OS. Emerging approaches extracellular vesicle-based nanomedicine warrant further investigation both diagnostic applications Integrating with other molecular cellular markers offers improved identification pregnancies.

Language: Английский

Citations

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