Cited by Nanofat and lipofilling for cutaneous fibrosis in scleroderma: Current evidence and future directions

Nanofat and lipofilling for cutaneous fibrosis in scleroderma: Current evidence and future directions DOI

et al.

Journal of Scleroderma and Related Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: May 15, 2025

Systemic sclerosis is a rare autoimmune disease characterized by progressive fibrosis, microvascular dysfunction, and chronic inflammation, leading to significant functional aesthetic impairments, particularly in the face hands. Current therapeutic strategies are limited their ability reverse established skin prompting interest regenerative approaches such as autologous fat grafting. Lipofilling nanofat techniques, originally developed for volume restoration rejuvenation, have demonstrated promising outcomes improving texture, elasticity, vascularization through mechanisms involving adipose-derived stem cells stromal vascular fraction. This editorial reviews available randomized controlled trials evaluating lipofilling treatment of cutaneous manifestations systemic sclerosis. A literature search identified four meeting inclusion criteria, primarily focused on facial grafting with or without platelet-rich plasma corticosteroid-resistant patients. Although subjective improvements quality were reported, methodological variability, small sample sizes, non-standardized techniques limit generalizability findings. Given minimally invasive nature grafting, it represents potentially valuable adjunct However, further research, including multicenter registries standardized protocols, essential better define its clinical utility optimize this complex disease.

Language: Английский

Clinical and ultrasonographic evaluation of breast lipofilling after expander extrusion. Case report DOI

R. Bogdan,

Alina Helgiu,

Anca Maria Cîmpean

et al.

Medicine and Pharmacy Reports, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

Breast cancer treatment often involves mastectomy and adjuvant therapies such as radiotherapy, which can lead to complications in reconstructive procedures. Tissue expanders are commonly used for immediate breast reconstruction post-mastectomy, but radiation therapy increases the risk of like expander extrusion. Lipofilling has emerged a promising technique address tissue damage improve outcomes. This case illustrates utility ultrasonography measuring fat thickness before after lipofilling procedure calculating resorption rate managing complex post-radiation complications. We report 38-year-old patient born raised Romania with history right cancer, who initially underwent followed by subpectoral expander. The subsequently received led extrusion chronic pain skin redness. Due significant surrounding chest wall, was employed approach enhance quality support regeneration. Fat grafting performed multiple sessions, ultrasonographic evaluations conducted each session monitor volumetric changes reconstructed breast. Following lipofilling, experienced marked improvements texture volume, no recurrence Later that year we DIEP flap. demonstrates efficacy graft strategy patients experience from post-radiation. Lipofilling, combination thorough imaging assessments, significantly outcomes following radiotherapy.

Language: Английский

Citations

Innovative use of autologous fat grafting and regenerative therapies in the surgical management of dermatological scarring disorders: a systematic review of functional and aesthetic outcomes DOI

Karla Enith Guamán Cevallos,

Elizabeth Arellano Pacheco,

Arcenio Galindo

et al.

International Journal of Research in Medical Sciences, Journal Year: 2025, Volume and Issue: 13(2), P. 797 - 804

Published: Jan. 30, 2025

A systematic strategy was adopted to evaluate efficacy of autologous fat grafting and regenerative therapies such as platelet-rich plasma (PRP) or stromal vascular fraction (SVF) for the management dermatological scarring disorders. In methodology, selected databases are PubMed, Scopus, Web Science Cochrane Library so total 25 studies were involving 2,130 patients with hypertrophic, keloid, atrophic scars. We conducted meta-analysis revealed 35% improvement in scar pliability a 40% enhancement aesthetic appearance assessed by validated scales. functional outcomes relief from pain itching improved 68% patient satisfaction scores increased significantly minor complications transient edema localized infection reported 8% cases. Regenerative potential amplified PRP SVF show ability promote dermal remodeling, angiogenesis tissue repair. results, fat-based demonstrated better results when compared traditional treatments our highlight more extensive, superior randomized controlled needed validate effectiveness improve procedures. illustrated how regeneration techniques can scarring.

Language: Английский

Citations

The Role of Autologous Fat Grafting in the Treatment of Atrophic Post-Acne Scars: A Narrative Review DOI

Abeer Attia Tawfik,

Mahmoud A. Rageh

Journal of Cutaneous Medicine and Surgery, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 4, 2025

Numerous techniques have been tried to treat acne scarring. Given its filling properties and the presence of adipose tissue-derived stem cells, autologous fat has for treating scars in multiple studies, either alone or combined with other treatment approaches. This review focuses on grafting different forms, including nanofat stromal vascular fraction, as an efficient safe modality scars. PubMed, Embase, Cochrane Library databases were used search relevant studies published from January 2017 December 2022. We a combination following keywords: “acne scar,” scars,” “autologous transplantation,” grafting,” “fat “stromal fraction,” “SVF,” “nanofat.” Twelve found utilizing methods such lasers platelet-rich plasma atrophic post-acne Most showed that effectively treated satisfying results.

Language: Английский

Citations

A Meta-analytic Review of Platelet-Rich Plasma in Fat Grafting: Enhancing Clinical Outcomes DOI