Matrix Metalloproteinases in Ureteropelvic Junction Obstruction: Their Role in Pathogenesis and Their Use as Clinical Markers DOI Creative Commons
Giusi Alberti, Eleonora Russo, Melania Lo Iacono

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(7), P. 520 - 520

Published: March 31, 2025

The obstruction of the urinary tract is responsible for obstructive nephropathy (ON), also known as uropathy, which may then evolve in a renal parenchymal disease (hydronephrosis). Regarding etiology ON, it has been linked to perturbation processes occurring during development such morphogenesis, maturation, and growth. Despite research carried out recent years, there still pressing need elucidate molecular underlying disease. This result definition novel biomarkers that can help patient stratification monitoring therapeutic choices. Matrix metalloproteinases (MMPs) are family zinc-dependent endopeptidases with key roles extracellular matrix remodeling due their wide cleavage specificity ability modulate bioavailability growth factors. changes local tissue microenvironment at site obstruction, role MMPs ureteropelvic junction (UPJO) and, therefore, pathogenesis damage ON not well-documented. In this review, we underline possible both UPJO progression related hydronephrosis. potential use detectable bodily fluids (such patient’s urine) discussed.

Language: Английский

Matrix Metalloproteinases in Ureteropelvic Junction Obstruction: Their Role in Pathogenesis and Their Use as Clinical Markers DOI Creative Commons
Giusi Alberti, Eleonora Russo, Melania Lo Iacono

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(7), P. 520 - 520

Published: March 31, 2025

The obstruction of the urinary tract is responsible for obstructive nephropathy (ON), also known as uropathy, which may then evolve in a renal parenchymal disease (hydronephrosis). Regarding etiology ON, it has been linked to perturbation processes occurring during development such morphogenesis, maturation, and growth. Despite research carried out recent years, there still pressing need elucidate molecular underlying disease. This result definition novel biomarkers that can help patient stratification monitoring therapeutic choices. Matrix metalloproteinases (MMPs) are family zinc-dependent endopeptidases with key roles extracellular matrix remodeling due their wide cleavage specificity ability modulate bioavailability growth factors. changes local tissue microenvironment at site obstruction, role MMPs ureteropelvic junction (UPJO) and, therefore, pathogenesis damage ON not well-documented. In this review, we underline possible both UPJO progression related hydronephrosis. potential use detectable bodily fluids (such patient’s urine) discussed.

Language: Английский

Citations

0