Linking Cardiovascular Disease and Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): The Role of Cardiometabolic Drugs in MASLD Treatment

Biomolecules, Journal Year: 2025, Volume and Issue: 15(3), P. 324 - 324

Published: Feb. 23, 2025

The link between cardiovascular disease (CVD) and metabolic dysfunction-associated steatotic liver (MASLD) is well-established at both the epidemiological pathophysiological levels. Among common mechanisms involved in development progression of diseases, oxidative stress inflammation, insulin resistance, lipid metabolism deterioration, hepatokines, gut dysbiosis along with genetic factors have been recognized to play a pivotal role. Pharmacologic interventions drugs targeting modifiable cardiometabolic risk factors, such as T2DM, dyslipidemia, hypertension, are reasonable strategy prevent CVD MASLD. Recently, novel drug for steatohepatitis (MASH), resmetirom, has shown positive effects regarding risk, opening new opportunities therapeutic approach MASLD CVD. This review provides current knowledge on epidemiologic association morbidity mortality enlightens possible underlying pathophysiologic linking role anti-hypertensive drugs, hypolipidemic agents, glucose-lowering medications, acetylsalicylic acid, thyroid hormone receptor-beta agonist also discussed. Metformin failed prove beneficial progression. Studies administration thiazolinediones suggest effectiveness improving steatosis, steatohepatitis, fibrosis, while newer categories agents GLP-1Ra SGLT-2i currently being tested their efficacy across whole spectrum Statins alone or combination ezetimibe yielded promising results. conduction long-duration, large, high-quality, randomized-controlled trials aiming assess by biopsy reverse great importance.

Language: Английский

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26‐Week Repeated‐Dose Toxicity Study of a Novel Antiarrhythmic Drug Sulcardine Sulfate in Sprague–Dawley Rats

Journal of Applied Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 16, 2025

Sulcardine sulfate (Sul) is a novel antiarrhythmic agent blocking multiple channels and exhibits unique pharmacological properties such as lower APD-dependent prolongation reduced arrhythmia risk. Sul currently in Phase III clinical trials, yet studies on its long-term toxicological profile potential target organs remain unexplored. This study investigated the related toxicity of Sprague Dawley (SD) rats through repeated oral administration for 26 weeks, followed by 4-week recovery period. Consistent with intended mode administration, was administered via gavage at daily doses 0, 175, 350, 700/525 mg/kg rats. On account clinically observed body weight loss male female high-dose group compared control group, one rat dying after 8 weeks high dose adjusted to 525 mg/kg. Aspartate aminotransferase (AST) alanine (ALT) levels significantly increased medium- groups, whereas these groups showed significant rise alkaline phosphatase (ALP) levels, accompanied varying degrees gain liver lungs. Additionally, brownish-red pigment deposition hepatocytes Kupffer cells across all dosing along foam cell alveolar cavities. Concomitant toxicokinetics that drug accumulated some extent animals. Consequently, lungs were identified organs, no adverse effect level (NOAEL) determined be 175

Language: Английский

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Insights into drug adverse reactions prediction through Mendelian randomization: a review

Postgraduate Medical Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Abstract Adverse drug reactions pose a significant threat to patient safety and public health often become apparent only after widespread clinical use. Mendelian randomization (MR) analysis is valuable tool that can be used infer causality by using genetic variants as instrumental variables, which predict the occurrence of adverse before they occur. Compared with traditional observational studies, MR Analysis reduce potential bias confounding factors. This article reviews principles its application in prediction reactions, challenges future directions, summarizes how harness power this innovative epidemiological method put us at forefront improving assessment personalized medicine.

Language: Английский

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Recent advancements in the application of multi-elemental profiling and ionomics in cardiovascular diseases

Journal of Trace Elements in Medicine and Biology, Journal Year: 2025, Volume and Issue: 88, P. 127616 - 127616

Published: Feb. 7, 2025

Language: Английский

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Beyond Cholesterol: Emerging Risk Factors in Atherosclerosis

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(7), P. 2352 - 2352

Published: March 29, 2025

Atherosclerosis remains a leading cause of cardiovascular morbidity and mortality worldwide, traditionally linked to elevated cholesterol levels, particularly low-density lipoprotein (LDL-C). However, despite aggressive lipid-lowering strategies, residual risk persists, underscoring the need explore additional contributing factors. This review examines emerging factors beyond cholesterol, including chronic inflammation, gut microbiota composition, oxidative stress, environmental exposures. Inflammation plays pivotal role in atherogenesis, with markers such as C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α) serving indicators disease activity. The microbiome, metabolites like trimethylamine N-oxide (TMAO), has been implicated vascular inflammation plaque development, while beneficial short-chain fatty acids (SCFAs) demonstrate protective effects. Oxidative stress further exacerbates endothelial dysfunction instability, driven by reactive oxygen species (ROS) lipid peroxidation. Additionally, factors, air pollution, heavy metal exposure, endocrine disruptors, psychological have emerged significant contributors disease. Understanding these novel offers broader perspective on atherosclerosis pathogenesis provides new avenues for targeted prevention therapeutic interventions.

Language: Английский

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Acacetin as a natural cardiovascular therapeutic: mechanisms and preclinical evidence

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 4, 2025

Globally, cardiovascular disease (CVD) has emerged as a leading cause of mortality and morbidity. As the world’s population ages, CVD incidence is on rise, extensive attention been drawn to optimizing therapeutic regimens. Acacetin, natural flavonoid derived from various plants, demonstrated have wide spectrum pharmacological properties, such antioxidant, anti-inflammatory, anti-bacterial, anti-tumor activities, well protective effects diverse tissues organs. Recently, increasing numbers studies (mostly preclinical) indicated that acacetin potential might become novel strategy for CVDs. The importance in treatment necessitates systematic comprehensive review its system underlying mechanisms involved. Here, we first provide an overview some basic properties acacetin. Subsequently, multiple CVDs, like arrhythmias, cardiac ischemia/reperfusion injury, atherosclerosis, myocardial hypertrophy fibrosis, drug-induced cardiotoxicity, diabetic cardiomyopathy, hypertension, senescence, are discussed detail. by which exhibits protection appear involve suppressing oxidative stress, reducing inflammation, preventing cardiomyocyte apoptosis endothelial cell regulating mitochondrial autophagy lipid metabolism. Meanwhile, several critical signaling pathways also found mediate against including phosphoinositide 3-kinase/protein kinase B/mechanistic target rapamycin (PI3K/Akt/mTOR), sirtuin 1/AMP-activated protein kinase/peroxisome proliferator-activated receptor-γ coactivator-1α (Sirt1/AMPK/PGC-1α), transforming growth factor-β1/small mothers decapentaplegic 3 (TGF-β1/Smad3), B/endothelial nitric oxide synthase (Akt/eNOS), others. Finally, highlight existing problems associated with need be addressed, requirement clinical evidence enhanced bioavailability, promising drug candidate.

Language: Английский

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Left Ventricular Longitudinal Strain Detects Ischemic Dysfunction at Rest, Reflecting Significant Coronary Artery Disease

Diagnostics, Journal Year: 2025, Volume and Issue: 15(9), P. 1102 - 1102

Published: April 26, 2025

Background/Objectives: The role of speckle-tracking echocardiography in the diagnosis stable coronary artery disease (CAD) remains controversial. aim this study was to assess diagnostic accuracy global longitudinal strain (GLS) predicting significant CAD. Methods: In prospective study, 103 symptomatic patients referred for invasive angiography were enrolled. All underwent resting with GLS assessment prior angiography. Exclusion criteria included acute syndrome, known history CAD, and presence left ventricular wall motion abnormalities. Significant CAD defined as ≥50% stenosis at least one major epicardial artery. Results: mean patient age 63.8 ± 9.3 years, 78.6% being male. Hypertension present 63.1% patients, dyslipidemia 77.7%, diabetes mellitus 22.3%, smoking 71.9%, a family premature 24.3%. identified 45.6% (n = 47), while remaining 54.3% 56) had non-significant or no disease. Patients exhibited significantly lower values compared those without (−15.73 2.64% vs. −17.6 1.85%, p 0.001). A threshold >−16.3 predicted 66% sensitivity 73.2% specificity (AUC 0.692, demonstrated identifying individual territories, AUCs 0.754 anterior descending (LAD), 0.714 circumflex (LCx), 0.723 right (RCA). Diagnostic performance improved when combined across all three territories 0.796). Conclusions: Resting myocardial is accurate detecting ischemic dysfunction can accurately predict respective branch subtending segments.

Language: Английский

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UHPLC-MS/MS method for the simultaneous quantification of five calcium channel antagonists’ drugs in human plasma

Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 184, P. 117873 - 117873

Published: Feb. 5, 2025

Language: Английский

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Exploring the impact of bioactive peptides from fermented Milk proteins: A review with emphasis on health implications and artificial intelligence integration

Food Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 144047 - 144047

Published: March 1, 2025

Language: Английский

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Cardiovascular Biomarkers: Tools for Precision Diagnosis and Prognosis

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3218 - 3218

Published: March 30, 2025

The present study provides a detailed review of cardiovascular biomarkers critical for the diagnosis, prognosis, and pathophysiology diseases, leading cause global morbidity mortality. These aid in detecting disease onset, progression, therapeutic responses, providing insights into molecular mechanisms. Enzyme markers like AST, CK-MB, LDH, CA-III, HBDH are pivotal myocardial injury during acute events. Protein such as CRP, H-FABP, MPO shed light on inflammation oxidative stress. Cardiac Troponins, gold standard infarction exhibit high specificity sensitivity, while IMA GPBB indicate ischemia early damage. Peptide markers, including BNP NT-proBNP, crucial heart failure diagnosis management, reflecting ventricular stress remodeling. Novel peptides MR-proANP MR-proADM assessing severity. Lipid lipoprotein-associated phospholipase A2 oxylipins provide lipid metabolism atherosclerosis. Inflammatory stress-related biomarkers, TNFα, IL-6, GDF-15, Pentraxin 3, illuminate chronic CVDs. Hormonal copeptin endothelin-1 highlight neurohormonal activation, emerging ST2, galectin-3, PAPP-A, TMAO elucidate fibrosis, remodeling, metabolic dysregulation. inclusion microRNAs long non-coding RNAs represents breakthrough biomarker research, offering sensitive tools detection, risk stratification, targeting. This emphasizes diagnostic prognostic utility these advancing care through personalized medicine.

Language: Английский

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