Aging, cancer, and autophagy: connections and therapeutic perspectives

Frontiers in Molecular Biosciences, Journal Year: 2025, Volume and Issue: 11

Published: Jan. 28, 2025

Aging and cancer are intricately linked through shared molecular processes that influence both the onset of malignancy progression age-related decline. As organisms age, cellular stress, genomic instability, an accumulation senescent cells create a pro-inflammatory environment conducive to development. Autophagy, process responsible for degrading recycling damaged components, plays pivotal role in this relationship. While autophagy acts as tumor-suppressive mechanism by preventing organelles proteins, often exploit it survive under conditions metabolic stress treatment resistance. The interplay between aging, cancer, reveals key insights into tumorigenesis, senescence, proteostasis dysfunction. This review explores connections these processes, emphasizing potential autophagy-targeted therapies strategies could be further explored aging treatment. Understanding dual roles suppressing promoting offers promising avenues therapeutic interventions aimed at improving outcomes elderly patients while addressing deterioration.

Language: Английский

The Anti-Aging Mechanism of Metformin: From Molecular Insights to Clinical Applications

Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 816 - 816

Published: Feb. 10, 2025

Aging represents a complex biological phenomenon marked by the progressive deterioration of physiological functions over time, reduced resilience, and increased vulnerability to age-related diseases, ultimately culminating in mortality. Recent research has uncovered diverse molecular mechanisms through which metformin extends its benefits beyond glycemic control, presenting it as promising intervention against aging. This review delves into anti-aging properties metformin, highlighting role mitochondrial energy modulation, activation AMPK-mTOR signaling pathway, stimulation autophagy, mitigation inflammation linked cellular Furthermore, we discuss influence on epigenetic modifications that underpin genomic stability homeostasis. Metformin's potential addressing age-associated disorders including metabolic, cardiovascular, neurodegenerative diseases is also explored. The Targeting with Metformin (TAME) trial aims provide key evidence efficacy delaying aging humans. Despite these insights, significant challenges persist gaining more comprehensive understanding underlying mechanisms, determining optimal dosing strategies, evaluating long-term safety non-diabetic populations. Addressing crucial fully realizing metformin's an therapeutic.

Language: Английский

Investigating the aging-modulatory mechanism of Rasayana Churna, an Ayurvedic herbal formulation, using a computational approach

Biogerontology, Journal Year: 2025, Volume and Issue: 26(2)

Published: Feb. 5, 2025

Language: Английский