Narrative Review and Guide: State of the Art and Emerging Opportunities of Bioprinting in Tissue Regeneration and Medical Instrumentation

Bioengineering, Journal Year: 2025, Volume and Issue: 12(1), P. 71 - 71

Published: Jan. 15, 2025

Three-dimensional printing was introduced in the 1980s, though bioprinting started developing a few years later. Today, 3D is making inroads medical fields, including production of biomedical supplies intended for internal use, such as biodegradable staples. Medical enables versatility and flexibility on demand able to modify individualize using several established methods. A great selection biomaterials bioinks available, natural, synthetic, mixed options; they are biocompatible non-toxic. Many accommodate cells so upon implantation, integrate within new environment. Bioprinting suitable tissues living or viable components, collagen scaffolding, cartilage cells, also parts structures, teeth, artificial man-made materials that will become embedded vivo. an integral part tissue engineering regenerative medicine. The addition newly developed smart capable incorporating dynamic changes shape depending nature stimuli led fourth dimension time form changing three static dimensions. Four-dimensional already significant medicine, ways create tissues. Its future lies constructing partial whole organ generation.

Language: Английский

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Organoid: Biomedical application, biobanking, and pathways to translation

Heliyon, Journal Year: 2025, Volume and Issue: unknown, P. e43028 - e43028

Published: Feb. 1, 2025

Language: Английский

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The rise of 3D bioprinting: from organs to personalized medicine

Patient-Oriented Medicine and Pharmacy, Journal Year: 2025, Volume and Issue: unknown

Published: March 7, 2025

Bioprinting has emerged as a groundbreaking technology in the realms of organ transplantation and regenerative medicine, addressing critical challenges such shortages tissue repair. This review explores technological advancements innovations bioprinting, highlighting state-of-the-art techniques, bioinks, applications engineering. Key milestones printing functional tissues, including vascularized transplantable prototypes, are discussed alongside role bioprinting personalized where patient-oriented models revolutionizing drug testing therapeutic strategies. Furthermore, this article examines ethical considerations associated with offering insights into its future potential to transform global healthcare.

Language: Английский

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From gut to liver: organoids as platforms for next-generation toxicology assessment vehicles for xenobiotics

Stem Cell Research & Therapy, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 26, 2025

Traditional toxicological assessment relied heavily on 2D cell cultures and animal models of study, which were inadequate for the precise prediction human response to chemicals. Researchers have now shifted focus organoids assessment. Organoids are 3D structures produced from stem cells that mimic shape functionality organs a number advantages compared traditional study. They capacity replicate intricate cellular microenvironment in vivo interactions. offer physiologically pertinent platform is useful researchers monitor responses more realistic manner evaluate drug toxicity. Additionally, can be created unique patient, allowing individualized research providing understanding inter-individual heterogeneity responses. Recent developments use gut liver xenobiotics (environmental toxins drugs) reviewed this article. Gut reveal potential damage digestive system how affect nutrient absorption barrier function. Liver primary site detoxification metabolism xenobiotics, usually routed gut. Hence, these linked crucial evaluating chemical or pollutant induced organ toxicity, forecasting their pharmacokinetics. When incorporated into development process, organoid improve accuracy efficiency safety assessments, leading safer effective treatments. We also discuss limitations using organoid-based assays, future prospects, including need standardized protocols overcoming reproducibility issues.

Language: Английский

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Advances and Challenges in 3D Bioprinted Cancer Models: Opportunities for Personalized Medicine and Tissue Engineering

Polymers, Journal Year: 2025, Volume and Issue: 17(7), P. 948 - 948

Published: March 31, 2025

Cancer is the second leading cause of death worldwide, after cardiovascular disease, claiming not only a staggering number lives but also causing considerable health and economic devastation, particularly in less-developed countries. Therapeutic interventions are impeded by differences patient-to-patient responses to anti-cancer drugs. A personalized medicine approach crucial for treating specific patient groups includes using molecular genetic screens find appropriate stratifications patients who will respond (and those not) treatment regimens. However, information on which risk stratification method can be used hone cancer types likely responders agent remains elusive most cancers. Novel developments 3D bioprinting technology have been widely applied recreate relevant bioengineered tumor organotypic structures capable mimicking human tissue microenvironment or adequate drug high-throughput screening settings. Parts autogenously printed form tissues computer-aided design concept where multiple layers include different cell compatible biomaterials build configurations. Patient-derived stromal cells, together with material, extracellular matrix proteins, growth factors, create bioprinted models that provide possible platform new therapies advance. Both natural synthetic biopolymers encourage cells biological materials models/implants. These may facilitate physiologically cell-cell cell-matrix interactions heterogeneity resembling real tumors.

Language: Английский

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Indirect Measurement of Cell Loading in Hydrogel Bioinks During Handling and Preparation of 3d Models

Published: Jan. 1, 2025

Language: Английский

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Bioprinting in Organ Transplantation: From Experimental Models to Clinical Prospects

Brazilian Journal of Transplantation, Journal Year: 2025, Volume and Issue: 28(1)

Published: April 25, 2025

Background: Bioprinting has emerged as an innovative technology in organ transplantation and regenerative medicine, aiming to address pressing challenges such the shortage of donor organs need for effective tissue repair. By leveraging advanced 3D printing techniques, bioprinting enables fabrication functional tissues with precise architectural biological properties. Methods: This review provides in-depth analysis latest advancements bioprinting, focusing on cutting-edge development bioinks, their applications engineering. It examines significant breakthroughs creation vascularized transplantable prototypes explores role personalized medicine. Results: The findings highlight transformative impact biomedical field, particularly drug testing, therapeutic modeling, patient-specific treatment strategies. Additionally, key challenges—including technological limitations, ethical concerns, regulatory considerations—are discussed provide a comprehensive understanding field’s progress potential obstacles. Conclusion: holds immense promise revolutionizing global healthcare by offering solutions shortages advancing However, continued research innovation are necessary overcome existing facilitate its clinical translation into mainstream medical practice.

Language: Английский

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Bioimpressão no Transplante de Órgãos: Dos Modelos Experimentais às Perspectivas Clínicas

Brazilian Journal of Transplantation, Journal Year: 2025, Volume and Issue: 28(1)

Published: April 25, 2025

Introdução: A bioimpressão despontou como uma tecnologia inovadora no transplante de órgãos e na medicina regenerativa, visando solucionar desafios urgentes, a escassez doadores necessidade reparo eficaz tecidos. Ao aproveitar as técnicas avançadas impressão 3D, permite fabricação tecidos funcionais com propriedades arquitetônicas biológicas precisas. Métodos: Esta revisão fornece análise detalhada dos últimos avanços em bioimpressão, concentrando-se ponta, desenvolvimento biotintas suas aplicações engenharia Ela examina os significativos criação protótipos vascularizados transplantáveis explora função da personalizada. Resultados: As descobertas destacam o impacto transformador campo biomédico, particularmente testes medicamentos, modelagem terapêutica estratégias tratamento específicas para paciente. Além disso, principais — incluindo limitações tecnológicas, preocupações éticas considerações regulatórias são discutidos fornecer compreensão abrangente do progresso possíveis obstáculos. Conclusão: é imensamente promissora revolucionar saúde global, oferecendo soluções avanço regenerativa. No entanto pesquisa inovação contínuas necessárias superar existentes facilitar sua tradução clínica prática médica convencional.

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Advancing Organ-on-a-Chip Systems: The Role of Scaffold Materials and Coatings in Engineering Cell Microenvironment

Polymers, Journal Year: 2025, Volume and Issue: 17(9), P. 1263 - 1263

Published: May 6, 2025

For organ-on-a-chip (OoC) engineering, the use of biocompatible coatings and materials is not only recommended but essential. Extracellular matrix (ECM) components are commonly used as due to their effects on cell orientation, protein expression, differentiation, adhesion. Among most frequently collagen, fibronectin, Matrigel, according specific type intended OoC application. Additionally, such polydimethylsiloxane (PDMS), thermoplastics, chitosan, alginate serve scaffolding biomechanical properties biocompatibility. Here, we discuss some employed coating techniques, including SAMs, dip coating, spin microcontact printing, 3D bioprinting, each offering advantages drawbacks. Current challenges comprise enhancing biocompatibility, exploring novel materials, improving scalability reproducibility.

Language: Английский

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3D-bioprinted urethral grafts: Revolutionizing urethral stricture treatment

Arab Journal of Urology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 11

Published: May 13, 2025

Language: Английский

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