Chronic Obstructive Pulmonary Disease and Type 2 Diabetes Mellitus: Complex Interactions and Clinical Implications
Journal of Clinical Medicine,
Journal Year:
2025,
Volume and Issue:
14(6), P. 1809 - 1809
Published: March 7, 2025
Chronic
obstructive
pulmonary
disease
(COPD)
and
type
2
diabetes
mellitus
(T2DM)
are
highly
prevalent
chronic
conditions,
frequently
coexisting
due
to
their
shared
pathophysiological
mechanisms
risk
factors.
Epidemiological
studies
estimate
that
up
30%
of
COPD
patients
have
comorbid
T2DM,
contributing
worsened
progression,
more
hospitalizations,
higher
mortality
rates.
Systemic
inflammation
in
contributes
insulin
resistance
by
increasing
pro-inflammatory
cytokines
(TNF-α,
IL-6,
CRP),
which
impair
glucose
metabolism
beta-cell
function.
Conversely,
hyperglycemia
T2DM
exacerbates
oxidative
stress,
leading
endothelial
dysfunction,
reduced
lung
function,
impaired
repair
mechanisms.
A
comprehensive
narrative
review
was
conducted
evaluate
the
interplay
between
examining
mechanisms,
clinical
consequences,
management
strategies.
The
co-occurrence
accelerates
development,
elevates
hospitalization
rates,
deteriorates
overall
prognosis.
Pharmacological
interactions
complicate
illness
treatment,
requiring
a
multidisciplinary
therapy
strategy.
Recent
data
underscore
need
integrate
palliative
care,
facilitate
decision-making,
provide
psychological
support
enhance
patient
outcomes.
Efficient
COPD-T2DM
comorbidity
necessitates
customized,
interdisciplinary
strategy
targets
both
respiratory
metabolic
health.
Preliminary
prognostic
dialogues,
holistic
lifestyle
modifications
can
improve
quality
life
results.
Language: Английский
Vitamin B6, cardiovascular diseases, and diabetes mellitus
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine),
Journal Year:
2025,
Volume and Issue:
21(1), P. 66 - 76
Published: Feb. 23, 2025
Vitamin
B6
is
a
broad
term
for
six
water-soluble
vitamins
that
can
change
forms.
These
include
pyridoxal,
pyridoxine,
pyridoxamine,
and
their
5-phosphorylated
forms,
which
are
pyridoxal
5’-phosphate
(PLP),
pyridoxine
5’-phosphate,
pyridoxamine
5’-phosphate.
PLP
the
biologically
active
form
of
vitamin
B6.
It
works
as
coenzyme
in
many
enzymatic
processes
speed
up
body’s
most
important
metabolic
reactions,
including
synthesis,
conversion
degradation
amines
amino
acids,
supply
one-carbon
units,
transsulfuration,
synthesis
tetrapyrrole
compounds
polyamines.
also
has
big
impact
on
metabolism
homocysteine
biosynthesis
different
neurotransmitters.
inhibits
production
reactive
oxygen
species
advanced
glycation
end
products,
genotoxic
linked
to
aging
diabetes
mellitus
(DM),
so
it
an
antioxidant.
In
addition,
functions
modulator
transcription
factors,
affects
activity
number
enzymes,
bind
steroid
hormone
receptors,
playing
role
membrane
transport.
Researchers
have
reported
patients
with
type
2
DM
cardiovascular
disease
(CVD)
exhibit
lower
levels
B6,
whereas
taking
supplements
lowers
risk
its
vascular
complications.
We
still
don’t
fully
understand
mechanisms
underlying
relationship
between
DM.
Instead,
growing
body
evidence
suggests
may
protect
against
complications
through
scavenger
species.
deficiency
been
clinically
significant
diseases,
autism,
schizophrenia,
Alzheimer’s
disease,
Parkinson’s
epilepsy,
Down
syndrome,
DM,
cancer,
although
remain
largely
unclear.
The
purpose
this
review
was
discuss
specifics
CVD
mellitus,
well
analyze
new
trends
directions
future
research.
analysis
focused
biological
tryptophan
metabolism,
correlation
CVD,
diabetes,
DNA
damage
diabetes.
search
conducted
Scopus,
Science
Direct
(from
Elsevier)
PubMed,
MEDLINE
databases.
keywords
used
were
“vitamin
B6”,
“cardiovascular
disease”,
“diabetes
mellitus”.
A
manual
bibliography
publications
identify
study
results
could
not
be
found
during
online
search.
Language: Английский
Body weight variability as a predictor of cardiovascular outcomes in type 1 diabetes: A nationwide cohort study
Diabetes Obesity and Metabolism,
Journal Year:
2024,
Volume and Issue:
27(2), P. 490 - 500
Published: Oct. 28, 2024
Intraindividual
body
weight
variability
(BWV),
that
is,
the
degree
of
fluctuations
over
time,
is
associated
with
an
increased
risk
cardiovascular
diseases
(CVDs)
in
multiple
settings.
The
impact
BWV
on
type
1
diabetes
(T1D)
remains
unclear,
despite
issues
relative
to
management
individuals
this
condition.
Language: Английский
Integrating cardiovascular risk biomarkers in the context of inflammaging
Aging,
Journal Year:
2024,
Volume and Issue:
16(19), P. 12670 - 12672
Published: Oct. 14, 2024
Language: Английский
Metabolic Dysfunction-Associated Steatotic Liver Disease in Type 2 Diabetes Patients—The Relationship with Platelets Indicators
Medicina,
Journal Year:
2024,
Volume and Issue:
60(12), P. 2091 - 2091
Published: Dec. 21, 2024
Background
and
Objectives:
Metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD)
is
an
important
chronic
with
major
health
risks,
especially
in
the
presence
of
T2DM,
but
pathophysiology
this
condition
not
fully
understood.
This
study
aimed
to
investigate
platelet
hematometric
indices
patients
T2DM
MASLD.
Materials
Methods:
Demographic
medical
(including
anthropometric)
data
were
collected
from
271
participants,
whom
blood
samples
also
drawn
fasting
conditions
for
complete
count,
metabolic
panel,
ferritin,
haptoglobin,
creatinine,
fibrosis
markers.
The
correlations
main
parameters
clinical
laboratory
investigated
by
bivariate
multiple
regression
analyses.
Results:
median
platelets
number
was
235·103/μL,
thus,
population
divided
into
two
subgroups:
higher
lower
numbers
(group
1
(mean):
286.38
±
43.29·103/μL
group
2
188.12
39.77·103/μL).
Despite
similar
BMIs,
had
fatty
index
(FLI)
(84.44
18.04
vs.
79.85
17.98;
p
=
0.0088)
insulin
resistance
(HOMA-IR:
3.16
1.50
2.63
1.31;
0.0008),
direct
bilirubin,
transaminases,
uric
acid,
ferritin
concentrations.
Higher
percentages
males
subjects
HOMA-IR
values
>2.5
accounted
group.
In
analyses,
count
plateletcrit
(PTC)
correlated
independently
sex,
leucocyte
HOMA-IR,
bilirubin
concentrations
(p
<
0.0001).
distribution
width
(PDW)
positively
separate
analyses
(β
0.060;
0.0004,
β
0.052;
0.0025),
GGT,
while
mean
volume
presented
a
weak
significant
positive
association
FLI.
Patients
PDW
PTC.
Conclusions:
Male
MASLD
PTC
larger
PDW.
associated
Language: Английский