The Impact of the Exposome on Alzheimer’s Disease: The Influence of Nutrition

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3015 - 3015

Published: March 26, 2025

Alzheimer's disease (AD) is a progressive neurodegenerative characterized by cognitive decline, memory loss, and behavioural changes. While genetic predispositions pathological processes have been the traditional focus, this review highlights fundamental role of environmental factors, particularly nutrition, within exposome framework in modulating risk progression AD. The exposome, which includes totality exposures an individual's lifetime, provides comprehensive approach to understanding complex aetiology In review, we explore impact dietary factors cyclic nucleotide pathways (cAMP/cGMP) on AD, emphasizing potential interventions as therapeutic strategies. We investigate key aspects how nutrition affects accumulation β-amyloid, aggregation tau proteins, neuroinflammation. also examine specific nutrients performance Additionally, discuss nutraceuticals with anti-phosphodiesterase activity various animal models AD (such 5xFAD, 3xTg-AD, Tg2576, APP/PS1 mice) demonstrating effects onset progression.

Language: Английский

Prospective Hepatoprotective Actions of Novel Nano-formulations of Sildenafil and Neem Extract in Counteracting Oral Carbon Tetrachloride-induced Liver Injury in Rats

Journal of Pharmaceutical Innovation, Journal Year: 2025, Volume and Issue: 20(2)

Published: April 1, 2025

Language: Английский