Heavy Metal Contamination: Sources, Health Impacts, and Sustainable Mitigation Strategies with Insights from Nigerian Case Studies DOI Creative Commons
Babafemi Laoye, Peter Taiwo Olagbemide,

T. A. Ogunnusi

et al.

F1000Research, Journal Year: 2025, Volume and Issue: 14, P. 134 - 134

Published: Feb. 18, 2025

Heavy metal contamination has gradually become a very much important significant global issue due to its continual existence in the environment and bioaccumulation ecosystems, posing deleterious risks human health. This review aims investigate sources, pathways, toxicological impacts of heavy metals such as cadmium, lead, mercury, arsenic, elucidating their health consequences plausible mitigation strategies. Furthermore, explores dual origins contamination; natural geological processes anthropogenic activities industrial emissions, mining, agricultural practices. These sip into soil, water, food chains, leading bioaccumulation, bio-magnification causing risks, including cardiovascular diseases, neurological disorders, reproductive toxicity. Additionally, addition indigenous case studies from Nigeria, lead poisoning Zamfara State Great Kwa River Cross Rivers underscores disproportionate impact pollution developing nations. reveal socio-economic environmental dimensions issue, providing contextual understanding region-specific vulnerabilities outcomes. To address these problems, evaluates already existing strategies, chelation therapy phytoremediation, while proposing sustainable, cost-effective solutions for reducing exposure mitigating impacts. It emphasizes importance integrative approaches involving policy, community engagement, technological innovations fight effectively. In conclusion, this seminar contributes toxicity, giving showcasing insights sources implications contamination. By integrating theoretical perspectives with practical solutions, provides robust framework informing policy makers advancing sustainable management practices.

Language: Английский

Mercury Exposure and Health Effects: What Do We Really Know? DOI Open Access
Angelika Edyta Charkiewicz, Wioleta Justyna Omeljaniuk, Marzena Garley

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2326 - 2326

Published: March 5, 2025

Mercury is widely used in medicine, agriculture, and industry. Meanwhile, according to the World Health Organization, it has been ranked as one of ten most hazardous substances world, with Agency for Toxic Substances Disease Registry ranking third. It no known positive functionality human body, even at low concentrations, can have harmful long-term health effects, seriously affecting healthcare system well posing a serious public threat. This review focuses on effects mercury its major sources environment. We highlight toxic role almost every possible aspect. forms, smallest doses, cause numerous disorders including nervous system, respiratory cardiovascular system. such various cancers; endothelial dysfunction; gastric vascular disorders; liver, kidney, brain damage; hormonal imbalances, miscarriages, reproductive skin lesions; vision death. The fact widespread use toxicity body prompts further in-depth research populations both moderate exposure. constant controlling monitoring problem, requiring urgent attention attentiveness from governments all countries and, long run, rapid concerted response. Thus, important analyze depth impact this highly metal prepare precisely targeted interventions among decision- policy-makers.

Language: Английский

Citations

1
Excessive Weight Gain During Pregnancy Increased Ponoxarase 1 Level in Neonatal Cord Blood DOI Creative Commons
Serhat Ege, Hasan Akduman, Ayşegül Aşır

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(1), P. 105 - 105

Published: Jan. 17, 2025

Maternal obesity is increasingly recognized as a risk factor for adverse fetal outcomes, primarily through its association with heightened oxidative stress. This study aimed to evaluate stress markers in umbilical cord blood of neonates born obese mothers. Sixty-three pregnant women, who were normal weight at the start pregnancy but classified term, included. Umbilical samples collected immediately post-delivery and analyzed serum (total oxidant status (TOS), total antioxidant (TAS), paraoxanase (PON), aryl esterase, thiol, catalase activities). Protein interaction networks generated using Cytoscape (v3.10.3), overlapping proteins further functional annotations ShinyGO (0.80). The top ten significantly enriched pathways identified false discovery rate (FDR) threshold <0.05. Significant associations found between maternal BMI change paraoxonase 1 (PON1) levels blood, while no correlation was observed other status) status, catalase). Additionally, analysis showed significant relationship gestational age, not demographic or clinical features. A 24 common protein interactors associated PON1, obesity, identified. Functional annotation revealed enrichment oxidoreductase activities, along involved insulin resistance, AGE-RAGE signaling, atherosclerosis. may specifically affect PON1 activity, potentially serving compensatory response neonates, suggesting possible biomarker stress-related metabolic disturbances mothers, implications monitoring managing outcomes populations.

Language: Английский

Citations

0
Heavy Metal Contamination: Sources, Health Impacts, and Sustainable Mitigation Strategies with Insights from Nigerian Case Studies DOI Creative Commons
Babafemi Laoye, Peter Taiwo Olagbemide,

T. A. Ogunnusi

et al.

F1000Research, Journal Year: 2025, Volume and Issue: 14, P. 134 - 134

Published: Jan. 27, 2025

Heavy metal contamination has gradually become a very much important significant global issue due to its continual existence in the environment and bioaccumulation ecosystems, posing deleterious risks human health. This review aims investigate sources, pathways, toxicological impacts of heavy metals such as cadmium, lead, mercury, arsenic, elucidating their health consequences plausible mitigation strategies. Furthermore, explores dual origins contamination; natural geological processes anthropogenic activities industrial emissions, mining, agricultural practices. These sip into soil, water, food chains, leading bioaccumulation, bio-magnification causing risks, including cardiovascular diseases, neurological disorders, reproductive toxicity. Additionally, addition indigenous case studies from Nigeria, lead poisoning Zamfara State Great Kwa River Cross Rivers underscores disproportionate impact pollution developing nations. reveal socio-economic environmental dimensions issue, providing contextual understanding region-specific vulnerabilities outcomes. To address these problems, evaluates already existing strategies, chelation therapy phytoremediation, while proposing sustainable, cost-effective solutions for reducing exposure mitigating impacts. It emphasizes importance integrative approaches involving policy, community engagement, technological innovations fight effectively. In conclusion, this seminar contributes toxicity, giving showcasing insights sources implications contamination. By integrating theoretical perspectives with practical solutions, provides robust framework informing policy makers advancing sustainable management practices.

Language: Английский

Citations

0
Heavy Metal Contamination: Sources, Health Impacts, and Sustainable Mitigation Strategies with Insights from Nigerian Case Studies DOI Creative Commons
Babafemi Laoye, Peter Taiwo Olagbemide,

T. A. Ogunnusi

et al.

F1000Research, Journal Year: 2025, Volume and Issue: 14, P. 134 - 134

Published: Feb. 18, 2025

Heavy metal contamination has gradually become a very much important significant global issue due to its continual existence in the environment and bioaccumulation ecosystems, posing deleterious risks human health. This review aims investigate sources, pathways, toxicological impacts of heavy metals such as cadmium, lead, mercury, arsenic, elucidating their health consequences plausible mitigation strategies. Furthermore, explores dual origins contamination; natural geological processes anthropogenic activities industrial emissions, mining, agricultural practices. These sip into soil, water, food chains, leading bioaccumulation, bio-magnification causing risks, including cardiovascular diseases, neurological disorders, reproductive toxicity. Additionally, addition indigenous case studies from Nigeria, lead poisoning Zamfara State Great Kwa River Cross Rivers underscores disproportionate impact pollution developing nations. reveal socio-economic environmental dimensions issue, providing contextual understanding region-specific vulnerabilities outcomes. To address these problems, evaluates already existing strategies, chelation therapy phytoremediation, while proposing sustainable, cost-effective solutions for reducing exposure mitigating impacts. It emphasizes importance integrative approaches involving policy, community engagement, technological innovations fight effectively. In conclusion, this seminar contributes toxicity, giving showcasing insights sources implications contamination. By integrating theoretical perspectives with practical solutions, provides robust framework informing policy makers advancing sustainable management practices.

Language: Английский

Citations

0