Multifaceted Therapeutic Potential of Plant-Derived Exosomes: Immunomodulation, Anticancer, Anti-Aging, Anti-Melanogenesis, Detoxification, and Drug Delivery
Biomolecules,
Journal Year:
2025,
Volume and Issue:
15(3), P. 394 - 394
Published: March 10, 2025
Most
eukaryotic
and
prokaryotic
cells
have
the
potential
to
secrete
a
group
of
structures/membrane-bound
organelles,
collectively
referred
as
extracellular
vesicles
(EVs),
which
offer
several
advantages
producer/receiver
cells.
This
review
provides
an
overview
EVs
from
plant
sources
with
emphasis
on
their
health-promoting
possible
use
therapeutic
agents.
highlights
essential
biological
effects
plant-derived
vesicles,
including
immune
modulation,
anticancer
activities,
protection
against
chemical
toxicity
pathogens,
well
anti-aging,
anti-melanogenesis,
anti-arthritic
effects,
along
ongoing
clinical
studies.
Evidence
revealed
that
EVs’
contents
exert
beneficial
properties
through
regulating
important
signaling
pathways
by
transferring
miRNAs
other
components.
Taken
all
together,
data
proposed
can
be
utilized
nutritional
compounds
agents,
such
drug
carriers.
However,
this
emerging
research
area
requires
further
in
vitro/in
vivo
studies
trials
determine
exact
underlying
mechanisms
positive
health
treating
various
diseases.
Language: Английский
Plant-Derived Extracellular Vesicles: Natural Nanocarriers for Biotechnological Drugs
Processes,
Journal Year:
2024,
Volume and Issue:
12(12), P. 2938 - 2938
Published: Dec. 23, 2024
Plant-derived
extracellular
vesicles
(PDEVs)
are
lipid
bilayer
nanoparticles,
naturally
produced
by
plant
cells,
with
sizes
ranging
from
50
to
500
nm.
Recent
studies
have
highlighted
their
great
potential
in
the
biotechnological
and
medical
fields,
due
natural
origin,
high
biocompatibility
intrinsic
therapeutic
properties.
PDEVs
contain
a
complex
biological
cargo
of
proteins,
lipids,
nucleic
acids
secondary
metabolites,
including
antioxidants
anti-inflammatory
molecules,
making
them
ideal
for
biomedical
applications
such
as
drug
delivery.
These
play
key
role
intercellular
communication
gene
regulation,
proving
be
particularly
promising
personalized
medicine.
ability
improve
stability
bioavailability,
optimizing
targeted
release
minimizing
side
effects.
Despite
some
challenges,
compositional
variability
need
standardized
protocols,
at
gunsight
innovative
research
aimed
improving
loading
capacity
specificity.
This
review
aims
provide
comprehensive
overview
PDEVs,
exploring
structure,
isolation
methods,
functional
characteristics,
applications,
highlighting
advantages
over
synthetic
nanoparticles
animal-derived
vesicles,
leading
an
sustainable
solution
development
new
approaches.
Language: Английский