Inhibition of MCP1 (CCL2) Enhances Antitumor Activity of NK Cells Against HCC Cells Under Hypoxia DOI Open Access

Hwan Hee Lee,

Jaehyun Kim,

Eunbi Park

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(10), P. 4900 - 4900

Published: May 20, 2025

Hypoxia, a low-oxygen state, is common feature of solid tumors. MCP1 (CCL2) small cytokine that closely related to hypoxia and has positive effect on tumor development. Hypoxia causes resistance various treatments for tumors the evasion cancer immune surveillance by lymphocytes. Natural killer (NK) cells are innate lymphocytes play an important role in development, particularly liver. First, it was found incubation HCC (2–5% O2) significantly increased production several inflammatory cytokines, including MCP1, compared normal oxygen (20% O2). Subsequently, blocking with anti-MCP1 antibody cultures inhibited growth migration vitro vivo. This associated decrease expression HIF-1α/STAT3 under hypoxia. Furthermore, cell chemotaxis activation NK-92 against cells. blockade induced shift NK CD56+dim population increase receptors NKG2D NKp44. In conclusion, modulation could enhance activity hypoxic

Language: Английский

Mesoporous polymeric nanoparticles for effective treatment of inflammatory diseases: an in vivo study DOI Creative Commons
Divya Pareek, Md. Zeyaullah,

Sukanya Patra

et al.

Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Glycine-based polymer nanoparticles for the treatment of inflammatory diseases without using any additional drugs.

Language: Английский

Citations

0
Healthcare inequities and healthcare providers: we are part of the problem DOI Creative Commons
Craig Campbell

International Journal for Equity in Health, Journal Year: 2025, Volume and Issue: 24(1)

Published: April 7, 2025

Language: Английский

Citations

0
Berry Fruit Extracts as Topical Cosmeceuticals for Skin Health Applications: A Systematic Review DOI Creative Commons
Filipe Silveira Azevedo,

Allan Rodrigues Pires,

Mary Ann Lila

et al.

Cosmetics, Journal Year: 2025, Volume and Issue: 12(3), P. 87 - 87

Published: April 23, 2025

Berries are a popular source of natural bioactive compounds with distinctive aspects and sensory attributes. In this review, the term “berry” refers to generally round, small, colorful, juicy fruits English common names ending in “berry”. They have high phenolic content, which has been linked their health-relevant properties. To gather information on potential berries for treating skin inflammatory diseases, systematic review was conducted following PRISMA guidelines (PROSPERO registration number CRD 42024549567), based studies from PubMed, Scopus, Web Science, Embase. It focused preclinical murine model studies, bias methodological quality assessed using SYRCLE’s RoB tool. Studies showed evidence that anti-inflammatory antioxidant properties due like anthocyanins, cyanidins, polyphenols, catechins. Berry exposure reduced oxidative stress markers, such as malondialdehyde, carbonylated proteins, nitric oxide, 8-OHdG, pyrimidine dimers. This reduction associated NF-κB COX-2 pathway downregulation, lower IL-6, IL-1β, TNF-α, MAPK, increased IL-10. Morphological outcomes included collagen, elastin, glycosaminoglycans, proteoglycans metalloproteinases. Bias analysis revealed low risk, suggesting reliable studies. treatments improved wound healing extracellular matrix (ECM) production, supporting pharmaceutical topical formulation.

Language: Английский

Citations

0
Inhibition of MCP1 (CCL2) Enhances Antitumor Activity of NK Cells Against HCC Cells Under Hypoxia DOI Open Access

Hwan Hee Lee,

Jaehyun Kim,

Eunbi Park

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(10), P. 4900 - 4900

Published: May 20, 2025

Hypoxia, a low-oxygen state, is common feature of solid tumors. MCP1 (CCL2) small cytokine that closely related to hypoxia and has positive effect on tumor development. Hypoxia causes resistance various treatments for tumors the evasion cancer immune surveillance by lymphocytes. Natural killer (NK) cells are innate lymphocytes play an important role in development, particularly liver. First, it was found incubation HCC (2–5% O2) significantly increased production several inflammatory cytokines, including MCP1, compared normal oxygen (20% O2). Subsequently, blocking with anti-MCP1 antibody cultures inhibited growth migration vitro vivo. This associated decrease expression HIF-1α/STAT3 under hypoxia. Furthermore, cell chemotaxis activation NK-92 against cells. blockade induced shift NK CD56+dim population increase receptors NKG2D NKp44. In conclusion, modulation could enhance activity hypoxic

Language: Английский

Citations

0