The epigenetic impact of lifestyle factors on metabolic syndrome: A systematic review DOI Creative Commons
Temitope Gabriel Adedeji

Journal of Clinical Sciences, Journal Year: 2025, Volume and Issue: 22(2), P. 108 - 118

Published: April 1, 2025

ABSTRACT Metabolic syndrome (MetS) is a cluster of metabolic abnormalities, including insulin resistance, obesity, dyslipidemia, and hypertension, increasing the risk cardiovascular disease diabetes. Lifestyle factors such as poor diet, sedentary behavior, smoking contribute to its rising prevalence. Emerging research suggests epigenetic modifications, DNA methylation, histone noncoding RNAs (ncRNAs), play crucial role in MetS. This review examines how lifestyle influence mechanisms that A comprehensive literature search was conducted using MEDLINE (via PubMed) Google Scholar, focusing on studies investigating effects physical activity, Relevant from reference lists were also included. Studies analyzing ncRNAs tissues prioritized. Exclusion criteria included lacking analysis or those unrelated Key data, findings, extracted, links between gene regulation. Poor diet induce modifications impair signaling, lipid metabolism, inflammation. Exercise balanced nutrition promote beneficial changes, enhancing mitochondrial function health. choices shape regulation influencing MetS risk. While habits worsen dysfunction, exercise proper can mitigate damage. Understanding these aid developing targeted interventions for prevention management.

Language: Английский

Harnessing Gut Microbiota for Biomimetic Innovations in Health and Biotechnology DOI Creative Commons
Ana Isabel Beltrán-Velasco, Vicente Javier Clemente‐Suárez

Biomimetics, Journal Year: 2025, Volume and Issue: 10(2), P. 73 - 73

Published: Jan. 24, 2025

The gut microbiota is a complex and dynamic ecosystem that plays fundamental role in human health by regulating immunity, metabolism, the gut–brain axis. Beyond its critical physiological functions, it has emerged as rich source of inspiration for biomimetic innovations healthcare biotechnology. This review explores transformative potential microbiota-based biomimetics, focusing on key biological mechanisms such resilience, self-regulation, quorum sensing. These have inspired development innovative applications, including personalized probiotics, synbiotics, artificial microbiomes, bioinspired biosensors, bioremediation systems. Such technologies aim to emulate optimize intricate functions microbial ecosystems, addressing challenges environmental sustainability. integration advanced technologies, intelligence, bioengineering, multi-omics approaches, further accelerated biomimetics. tools enable precision therapies tailored individual profiles, enhance efficacy diagnostic systems, facilitate design environmentally sustainable solutions, waste-to-energy systems platforms. Emerging areas innovation, gut-on-chip models synthetic biology, offer unprecedented opportunities studying applying principles controlled environments. Despite these advancements, remain. replication complexity environments, ethical concerns regarding genetically engineered microorganisms, equitable access are hurdles must be addressed. underscores importance interdisciplinary collaboration public awareness overcoming barriers ensuring responsible solutions. By leveraging biomimetics represents promising frontier approach revolutionize therapeutic strategies, redefine tools, address global challenges, paving way more personalized, efficient, future medicine

Language: Английский

Citations

3
Yoga an integrated mind body intervention for improvement in quality of life in individuals with Alzheimer’s disease and their caregivers DOI Creative Commons

Meenakshi Kaushik,

Anjali Yadav, Abhinav Upadhyay

et al.

Frontiers in Aging, Journal Year: 2025, Volume and Issue: 6

Published: March 21, 2025

Background and objective Alzheimer’s disease (AD) presents profound challenges, significantly impairing quality of life (QOL) for patients increasing the burden on caregivers. This study aims to investigate effectiveness a tailored 12-week yoga intervention in improving individuals with mild moderate AD reducing caregiver (CB). Methods is interventional healthy controls enrolled 30 participants (18 males, 12 females) diagnosed by an expert neurologist. Participants were aged 60 years or older recruited from old age home. A program, including specific postures (asanas), pranayama (breathing exercises), meditation, was conducted 1 hour daily, 6 days week. Neurocognitive assessments performed pre- post-intervention using Geriatric Depression Scale (GDS), Montreal Cognitive Assessment (MoCA), Caregiver Burden (CB) Scale. MoCA scores analyzed across domains, language, memory, attention, visuospatial ability, delayed recall, abstraction, orientation. Results The led significant improvements quality-of-life measures. GDS decreased 8.36 ± 2.79 5.13 3.07 (P < 0.01; 95% CI: −3.98 −2.31), while total improved 18.23 4.90 21.10 5.09 2.17–3.89). Domain-specific also showed enhancements, particularly recall. burden, measured CB Scale, demonstrated notable reductions following −2.54 −1.23). Conclusion underscores depression cognitive function, overall AD. Additionally, alleviated highlighting its potential as effective mind-body approach management.

Language: Английский

Citations

0
The epigenetic impact of lifestyle factors on metabolic syndrome: A systematic review DOI Creative Commons
Temitope Gabriel Adedeji

Journal of Clinical Sciences, Journal Year: 2025, Volume and Issue: 22(2), P. 108 - 118

Published: April 1, 2025

ABSTRACT Metabolic syndrome (MetS) is a cluster of metabolic abnormalities, including insulin resistance, obesity, dyslipidemia, and hypertension, increasing the risk cardiovascular disease diabetes. Lifestyle factors such as poor diet, sedentary behavior, smoking contribute to its rising prevalence. Emerging research suggests epigenetic modifications, DNA methylation, histone noncoding RNAs (ncRNAs), play crucial role in MetS. This review examines how lifestyle influence mechanisms that A comprehensive literature search was conducted using MEDLINE (via PubMed) Google Scholar, focusing on studies investigating effects physical activity, Relevant from reference lists were also included. Studies analyzing ncRNAs tissues prioritized. Exclusion criteria included lacking analysis or those unrelated Key data, findings, extracted, links between gene regulation. Poor diet induce modifications impair signaling, lipid metabolism, inflammation. Exercise balanced nutrition promote beneficial changes, enhancing mitochondrial function health. choices shape regulation influencing MetS risk. While habits worsen dysfunction, exercise proper can mitigate damage. Understanding these aid developing targeted interventions for prevention management.

Language: Английский

Citations

0