Motile cilia: Key developmental and functional roles in reproductive systems DOI Open Access
Shiyu Yang, Xiaoli Wang,

Huihui Gao

et al.

Andrology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Abstract Background Cilia are specialized microtubule‐based organelles that extend from the cell surface and classified into non‐motile motile types. The assembly function of cilia regulated by a complex molecular network enables to generate fluid flow across epithelial surfaces through coordinated beating. These found in respiratory, nervous, reproductive systems. In males, efferent ducts facilitate transport sperm testis epididymis. females, they mainly oviducts, where help transport, nourish fertilize eggs, also present endometrial epithelium. Material‐Methods This review compares common factors affect both male female tracts, discusses origin development multiciliated within enumerates infertility or related diseases may arise due defects. Results‐Discussion create turbulence their beating, which keeps semen suspended prevents ductal obstruction. distributed on epithelia oviducts endometrium. Specifically, infundibulum oviduct aid capturing oocytes, while isthmus region have been bind heads, facilitating formation reservoir. Several factors, such as miR‐34b/c miR‐449, TAp73, Gemc1, estrogen, etc., shown play crucial regulatory roles thereby further influencing fertility outcomes. Conclusions Pathogenic mutations disrupt ciliary can impair ciliogenesis alter structure flagella, potentially resulting infertility. Consequently, tracts for fertility. There still numerous unresolved mysteries surrounding these merit investigation researchers, hold great significance clinical diagnosis treatment disorders.

Language: Английский

Motile cilia: Key developmental and functional roles in reproductive systems DOI Open Access
Shiyu Yang, Xiaoli Wang,

Huihui Gao

et al.

Andrology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Abstract Background Cilia are specialized microtubule‐based organelles that extend from the cell surface and classified into non‐motile motile types. The assembly function of cilia regulated by a complex molecular network enables to generate fluid flow across epithelial surfaces through coordinated beating. These found in respiratory, nervous, reproductive systems. In males, efferent ducts facilitate transport sperm testis epididymis. females, they mainly oviducts, where help transport, nourish fertilize eggs, also present endometrial epithelium. Material‐Methods This review compares common factors affect both male female tracts, discusses origin development multiciliated within enumerates infertility or related diseases may arise due defects. Results‐Discussion create turbulence their beating, which keeps semen suspended prevents ductal obstruction. distributed on epithelia oviducts endometrium. Specifically, infundibulum oviduct aid capturing oocytes, while isthmus region have been bind heads, facilitating formation reservoir. Several factors, such as miR‐34b/c miR‐449, TAp73, Gemc1, estrogen, etc., shown play crucial regulatory roles thereby further influencing fertility outcomes. Conclusions Pathogenic mutations disrupt ciliary can impair ciliogenesis alter structure flagella, potentially resulting infertility. Consequently, tracts for fertility. There still numerous unresolved mysteries surrounding these merit investigation researchers, hold great significance clinical diagnosis treatment disorders.

Language: Английский

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