Herpes simplex virus‐1 infection alters microtubule‐associated protein Tau splicing and promotes Tau pathology in neural models of Alzheimer's disease DOI Creative Commons
Emmanuel C. Ijezie, Michael J. Miller, Céline Hardy

et al.

Brain Pathology, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Herpes simplex virus 1 (HSV-1) infection alters critical markers of Alzheimer's disease (AD) in neurons. One key marker AD is the hyperphosphorylation Tau, accompanied by altered levels Tau isoforms. However, an imbalance these splice variants, specifically resulting from 3R to 4R MAPT splicing exon 10, has yet be directly associated with HSV-1 infection. To this end, we infected 2D and 3D human neural models monitored phosphorylation. Further, transduced SH-SY5Y neurons ICP27, which RNA splicing, analyze if ICP27 alone sufficient induce 10 splicing. We show that induces increasing 4R-Tau protein levels, hyperphosphorylation, oligomerization. Our experiments reveal a novel link between development cytopathic phenotypes linked progression.

Language: Английский

Herpes simplex virus‐1 infection alters microtubule‐associated protein Tau splicing and promotes Tau pathology in neural models of Alzheimer's disease DOI Creative Commons
Emmanuel C. Ijezie, Michael J. Miller, Céline Hardy

et al.

Brain Pathology, Journal Year: 2025, Volume and Issue: unknown

Published: March 26, 2025

Herpes simplex virus 1 (HSV-1) infection alters critical markers of Alzheimer's disease (AD) in neurons. One key marker AD is the hyperphosphorylation Tau, accompanied by altered levels Tau isoforms. However, an imbalance these splice variants, specifically resulting from 3R to 4R MAPT splicing exon 10, has yet be directly associated with HSV-1 infection. To this end, we infected 2D and 3D human neural models monitored phosphorylation. Further, transduced SH-SY5Y neurons ICP27, which RNA splicing, analyze if ICP27 alone sufficient induce 10 splicing. We show that induces increasing 4R-Tau protein levels, hyperphosphorylation, oligomerization. Our experiments reveal a novel link between development cytopathic phenotypes linked progression.

Language: Английский

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