IgE‐Mediated Activation of Mast Cells and Basophils in Health and Disease DOI

Nicolas Charles,

Ulrich Blank

Immunological Reviews, Journal Year: 2025, Volume and Issue: 331(1)

Published: March 31, 2025

Type 2-mediated immune responses protect the body against environmental threats at barrier surfaces, such as large parasites and toxins, facilitate repair of inflammatory tissue damage. However, maladaptive to typically nonpathogenic substances, commonly known allergens, can lead development allergic diseases. 2 immunity involves a series prototype TH2 cytokines (IL-4, IL-5, IL-13) alarmins (IL-33, TSLP) that promote generation adaptive CD4+ helper cells humoral products allergen-specific IgE. Mast basophils are integral players in this network, serving primary effectors IgE-mediated responses. These bind IgE via high-affinity receptors (FcεRI) expressed on their surface and, upon activation by release variety mediators regulate responses, attract modulate other cells, contribute repair. Here, we review biology effector mechanisms these focusing primarily role mediating both physiological pathological contexts.

Language: Английский

IgE‐Mediated Activation of Mast Cells and Basophils in Health and Disease DOI

Nicolas Charles,

Ulrich Blank

Immunological Reviews, Journal Year: 2025, Volume and Issue: 331(1)

Published: March 31, 2025

Type 2-mediated immune responses protect the body against environmental threats at barrier surfaces, such as large parasites and toxins, facilitate repair of inflammatory tissue damage. However, maladaptive to typically nonpathogenic substances, commonly known allergens, can lead development allergic diseases. 2 immunity involves a series prototype TH2 cytokines (IL-4, IL-5, IL-13) alarmins (IL-33, TSLP) that promote generation adaptive CD4+ helper cells humoral products allergen-specific IgE. Mast basophils are integral players in this network, serving primary effectors IgE-mediated responses. These bind IgE via high-affinity receptors (FcεRI) expressed on their surface and, upon activation by release variety mediators regulate responses, attract modulate other cells, contribute repair. Here, we review biology effector mechanisms these focusing primarily role mediating both physiological pathological contexts.

Language: Английский

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