Downregulation of MGAT3 Promotes Benzo[a]pyrene-Mediated Lung Carcinogenesis by Regulating Cell Invasion and Migration Activity DOI Creative Commons
Su Zhang,

Xia-Yan Zhang,

Xiaochun Zheng

et al.

ACS Omega, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

Environmental chemical carcinogens are major factors in the induction of lung cancer, with benzo[a]pyrene (B[a]P) being one most widespread and highly carcinogenic among them. Although studies have reported that B[a]P exerts its effects by causing mutations, inducing cytotoxicity, inhibiting DNA synthesis, early molecular regulatory events mechanisms involved B[a]P-induced tumor initiation remain unclear. This study found MGAT3 gene was significantly downregulated mouse tumorigenesis, suggesting important tumor-suppressive function. Further investigation revealed suppression expression promoted invasion migration abilities cancer cells, while overexpression these cells inhibited effects. Western blot analysis also showed regulated epithelial-mesenchymal transition markers, thereby affecting motility cells. Xenograft assay confirmed inhibitory effect on proliferation. Analysis tissue further validated is tissues, this decrease associated a poor prognosis patients. Our research indicates downstream molecules plays crucial role development induced environmental carcinogens.

Language: Английский

Downregulation of MGAT3 Promotes Benzo[a]pyrene-Mediated Lung Carcinogenesis by Regulating Cell Invasion and Migration Activity DOI Creative Commons
Su Zhang,

Xia-Yan Zhang,

Xiaochun Zheng

et al.

ACS Omega, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

Environmental chemical carcinogens are major factors in the induction of lung cancer, with benzo[a]pyrene (B[a]P) being one most widespread and highly carcinogenic among them. Although studies have reported that B[a]P exerts its effects by causing mutations, inducing cytotoxicity, inhibiting DNA synthesis, early molecular regulatory events mechanisms involved B[a]P-induced tumor initiation remain unclear. This study found MGAT3 gene was significantly downregulated mouse tumorigenesis, suggesting important tumor-suppressive function. Further investigation revealed suppression expression promoted invasion migration abilities cancer cells, while overexpression these cells inhibited effects. Western blot analysis also showed regulated epithelial-mesenchymal transition markers, thereby affecting motility cells. Xenograft assay confirmed inhibitory effect on proliferation. Analysis tissue further validated is tissues, this decrease associated a poor prognosis patients. Our research indicates downstream molecules plays crucial role development induced environmental carcinogens.

Language: Английский

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