LncRNAs Regulate Vasculogenic Mimicry in Human Cancers DOI Creative Commons
Eloísa Ibarra-Sierra, Mercedes Bermúdez, Carlos Esteban Villegas‐Mercado

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(8), P. 616 - 616

Published: April 20, 2025

Vasculogenic mimicry (VM) has recently been discovered as an alternative mechanism for nourishing cancer cells in vivo. During VM, tumor align and organize themselves into three-dimensional (3D) channel-like structures to transport nutrients oxygen the internal layers of tumors. This mainly occurs aggressive solid tumors associated with poor prognosis oncologic patients. Long non-coding RNAs (lncRNAs) are essential regulators protein-encoding genes involved development progression. These single-stranded RNA molecules regulate critical cellular functions including cell proliferation, apoptosis, angiogenesis, therapy response, migration, invasion, metastasis. Recently, high-throughput RNA-sequencing technologies have identified thousands lncRNAs, but only a small percentage them functionally characterized human cancers. The vast amount data about its genomic expression can allow us dissect their biology make suitable biomarkers diagnosis prognosis. In this study, we reviewed current knowledge role lncRNAs regulating VM cancer. We also examined molecular mechanisms highlight several commonalities between diverse types. Future directions research focused on deciphering function delineated. Finally, potential selected novel therapeutic targets RNA-based interventions is discussed.

Language: Английский

LncRNAs Regulate Vasculogenic Mimicry in Human Cancers DOI Creative Commons
Eloísa Ibarra-Sierra, Mercedes Bermúdez, Carlos Esteban Villegas‐Mercado

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(8), P. 616 - 616

Published: April 20, 2025

Vasculogenic mimicry (VM) has recently been discovered as an alternative mechanism for nourishing cancer cells in vivo. During VM, tumor align and organize themselves into three-dimensional (3D) channel-like structures to transport nutrients oxygen the internal layers of tumors. This mainly occurs aggressive solid tumors associated with poor prognosis oncologic patients. Long non-coding RNAs (lncRNAs) are essential regulators protein-encoding genes involved development progression. These single-stranded RNA molecules regulate critical cellular functions including cell proliferation, apoptosis, angiogenesis, therapy response, migration, invasion, metastasis. Recently, high-throughput RNA-sequencing technologies have identified thousands lncRNAs, but only a small percentage them functionally characterized human cancers. The vast amount data about its genomic expression can allow us dissect their biology make suitable biomarkers diagnosis prognosis. In this study, we reviewed current knowledge role lncRNAs regulating VM cancer. We also examined molecular mechanisms highlight several commonalities between diverse types. Future directions research focused on deciphering function delineated. Finally, potential selected novel therapeutic targets RNA-based interventions is discussed.

Language: Английский

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