The Legacy of COVID-19 in Breast Milk: The Association of Elevated Anti-Inflammatory and Antimicrobial Proteins with Vaccination or Infection DOI Creative Commons
Felicia Trofin, Petru Cianga, Daniela Constantinescu

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(3), P. 182 - 182

Published: March 11, 2025

Background: Breast milk is a rich source of antimicrobial and anti-inflammatory compounds, owing to its diverse array bioactive molecules. This study explores the presence activity natural agents in breast milk, particularly context SARS-CoV-2 pandemic. Materials Methods: samples were collected from 50 breastfeeding mothers, including those who had either been vaccinated against or recovered infection. These compared with control group consisting 10 unvaccinated mothers no history COVID-19. Key immune-regulatory proteins—lactoferrin, lactadherin, furin, tenascin C, granzyme B, chitinase 3-like 1—were quantified using Luminex multiplex analyzer. Results Discussion: All targeted biomarkers detected providing insights into immune profile transferred infants following COVID-19 infection vaccination. molecules highlight breastfeeding’s role passive immunity protection. The protein levels found be influenced by factors such as maternal inflammation, infant age, delivery mode, parity, emphasizing dynamic interaction between immunity, lactation biology, development. Conclusion: Breastfeeding serves powerful anti-SARS-CoV-2 defense mechanism, supported lactoferrin, reinforcing critical child health.

Language: Английский

The Legacy of COVID-19 in Breast Milk: The Association of Elevated Anti-Inflammatory and Antimicrobial Proteins with Vaccination or Infection DOI Creative Commons
Felicia Trofin, Petru Cianga, Daniela Constantinescu

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(3), P. 182 - 182

Published: March 11, 2025

Background: Breast milk is a rich source of antimicrobial and anti-inflammatory compounds, owing to its diverse array bioactive molecules. This study explores the presence activity natural agents in breast milk, particularly context SARS-CoV-2 pandemic. Materials Methods: samples were collected from 50 breastfeeding mothers, including those who had either been vaccinated against or recovered infection. These compared with control group consisting 10 unvaccinated mothers no history COVID-19. Key immune-regulatory proteins—lactoferrin, lactadherin, furin, tenascin C, granzyme B, chitinase 3-like 1—were quantified using Luminex multiplex analyzer. Results Discussion: All targeted biomarkers detected providing insights into immune profile transferred infants following COVID-19 infection vaccination. molecules highlight breastfeeding’s role passive immunity protection. The protein levels found be influenced by factors such as maternal inflammation, infant age, delivery mode, parity, emphasizing dynamic interaction between immunity, lactation biology, development. Conclusion: Breastfeeding serves powerful anti-SARS-CoV-2 defense mechanism, supported lactoferrin, reinforcing critical child health.

Language: Английский

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