Mas Receptor as a Target for Neuropathic Pain Management: Insights into Angiotensin-(1-7) Signaling and Therapeutic Opportunities DOI

Surekha A. Devi,

Saajan Kumar Sharma,

Sandip Tejpal

et al.

Journal for Research in Applied Sciences and Biotechnology, Journal Year: 2025, Volume and Issue: 4(2), P. 167 - 176

Published: April 30, 2025

Mas is a G protein-coupled receptor (GPCR) that binds to Angiotensin (1-7) and it evaluated as an important element of non classical Renin System. While the RAS axis has been considered pro-inflammatory pro-nociceptive by leveraging II AT1 receptor, /Mas offers anti-inflammatory, vessels dilating, neuroprotective functions. It produced two mechanisms first, obtained from via mechanism angiotensin converting enzyme 2 (ACE2) also binding formed Ang-(1-7) its activates several signaling pathways such PI3K/Akt, ERK1/2 nitric oxide (NO). These together prevent neuronal death, decrease oxidative stress inhibit nuclear factor-kappa B (NF-κB), reduces expression various cytokines like TNF-α, IL-1β IL-6. With regard neuropathic pain, contributes regulation glial-neuronal crosstalk negative microglial astrocytic activity neuroimmune balance. Experimental studies have shown use or synthetic activators attenuates mechanical alodynia thermal hypoesthesia, proving Marques colleagues’ hypothesis possible therapeutic applications. Also, functional cross-talk with other pain-modulatory systems, including endogenous opioid endocannabinoid contributing enhancer this sort analgesia. Thus, novel (1-7)/Mas pathway can be promising candidate for new non-opioid analgesic treatment pain. Further research in agonists, peptide analogs, targeted drug delivery system shows there potential practical application these discoveries.

Language: Английский

Mas Receptor as a Target for Neuropathic Pain Management: Insights into Angiotensin-(1-7) Signaling and Therapeutic Opportunities DOI

Surekha A. Devi,

Saajan Kumar Sharma,

Sandip Tejpal

et al.

Journal for Research in Applied Sciences and Biotechnology, Journal Year: 2025, Volume and Issue: 4(2), P. 167 - 176

Published: April 30, 2025

Mas is a G protein-coupled receptor (GPCR) that binds to Angiotensin (1-7) and it evaluated as an important element of non classical Renin System. While the RAS axis has been considered pro-inflammatory pro-nociceptive by leveraging II AT1 receptor, /Mas offers anti-inflammatory, vessels dilating, neuroprotective functions. It produced two mechanisms first, obtained from via mechanism angiotensin converting enzyme 2 (ACE2) also binding formed Ang-(1-7) its activates several signaling pathways such PI3K/Akt, ERK1/2 nitric oxide (NO). These together prevent neuronal death, decrease oxidative stress inhibit nuclear factor-kappa B (NF-κB), reduces expression various cytokines like TNF-α, IL-1β IL-6. With regard neuropathic pain, contributes regulation glial-neuronal crosstalk negative microglial astrocytic activity neuroimmune balance. Experimental studies have shown use or synthetic activators attenuates mechanical alodynia thermal hypoesthesia, proving Marques colleagues’ hypothesis possible therapeutic applications. Also, functional cross-talk with other pain-modulatory systems, including endogenous opioid endocannabinoid contributing enhancer this sort analgesia. Thus, novel (1-7)/Mas pathway can be promising candidate for new non-opioid analgesic treatment pain. Further research in agonists, peptide analogs, targeted drug delivery system shows there potential practical application these discoveries.

Language: Английский

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