Cells,
Journal Year:
2020,
Volume and Issue:
9(10), P. 2253 - 2253
Published: Oct. 8, 2020
Female
infertility
is
a
global
medical
condition
that
can
be
caused
by
various
disorders
of
the
reproductive
system,
including
premature
ovarian
failure
(POF),
polycystic
ovary
syndrome
(PCOS),
endometriosis,
Asherman
syndrome,
and
preeclampsia.
It
affects
quality
life
both
patients
couples.
Mesenchymal
stem
cells
(MSCs)
have
received
increasing
attention
as
potential
cell-based
therapy,
with
several
advantages
over
other
cell
sources,
greater
abundance,
fewer
ethical
considerations,
high
capacity
for
self-renewal
differentiation.
Clinical
researchers
examined
therapeutic
use
MSCs
in
female
infertility.
In
this
review,
we
discuss
recent
studies
on
lead
to
We
also
describe
role
microRNAs
(miRNAs)
exosomal
miRNAs
controlling
MSC
gene
expression
driving
outcomes.
The
clinical
application
holds
great
promise
treatment
or
insufficiency,
improve
health
significant
number
women
worldwide.
Journal of Ovarian Research,
Journal Year:
2022,
Volume and Issue:
15(1)
Published: Sept. 1, 2022
Abstract
Ovarian
aging
refers
to
the
process
by
which
ovarian
function
declines
until
eventual
failure.
The
pathogenesis
of
is
complex
and
diverse;
oxidative
stress
(OS)
considered
be
a
key
factor.
This
review
focuses
on
fact
that
OS
status
accelerates
promoting
apoptosis,
inflammation,
mitochondrial
damage,
telomere
shortening
biomacromolecular
damage.
Current
evidence
suggests
aging,
smoking,
high-sugar
diets,
pressure,
superovulation,
chemotherapeutic
agents
industrial
pollutants
can
factors
accelerate
exacerbating
status.
In
addition,
we
role
nuclear
factor
E2-related
2
(Nrf2),
Sirtuin
(Sirt),
mitogen-activated
protein
kinase
(MAPK),
B
(AKT),
Forkhead
box
O
(FoxO)
Klotho
signaling
pathways
during
aging.
We
also
explore
antioxidant
therapies
such
as
melatonin,
vitamins,
stem
cell
therapies,
monomers
Traditional
Chinese
Medicine
(TCM),
investigate
roles
these
supplements
with
respect
reduction
improvement
function.
provides
rationale
for
therapy
improve
General Psychiatry,
Journal Year:
2023,
Volume and Issue:
36(5), P. e101143 - e101143
Published: Oct. 1, 2023
There
have
been
no
effective
treatments
for
slowing
or
reversing
Alzheimer's
disease
(AD)
until
now.
Growing
preclinical
evidence,
including
this
study,
suggests
that
mesenchymal
stem
cells-secreted
exosomes
(MSCs-Exos)
the
potential
to
cure
AD.
Journal of Advanced Research,
Journal Year:
2024,
Volume and Issue:
70, P. 103 - 124
Published: May 9, 2024
Mesenchymal
stem
cell
(MSC)-based
therapies
have
yielded
beneficial
effects
in
a
broad
range
of
preclinical
models
and
clinical
trials
for
human
diseases.
In
the
context
MSC
transplantation,
it
is
widely
recognized
that
main
mechanism
regenerative
potential
MSCs
not
their
differentiation,
with
vivo
data
revealing
transient
low
engraftment
rates.
Instead,
therapeutic
are
mainly
attributed
to
its
secretome,
i.e.,
paracrine
factors
secreted
by
these
cells,
further
offering
more
attractive
innovative
approach
due
effectiveness
safety
cell-free
product.
this
review,
we
will
discuss
benefits
MSC-derived
secretome
medicine
particular
focus
on
respiratory,
hepatic,
neurological
Both
free
vesicular
be
detailed.
We
also
address
novel
strategies
capable
improving
healing
potential,
namely
delivering
important
molecules
according
specific
diseases
tissue
needs,
as
well
non-clinical
studies
allow
us
dissect
mechanisms
action.
includes
both
soluble
non-soluble
factors,
organized
extracellular
vesicles
(EVs).
Importantly,
besides
depending
origin,
characteristics
deeply
influenced
external
stimuli,
highlighting
possibility
optimizing
through
preconditioning
approaches.
Nevertheless,
clarity
around
action
remains
ambiguous,
whereas
need
standardized
procedures
successful
translation
those
products
clinics
urges.
Alzheimer s Research & Therapy,
Journal Year:
2020,
Volume and Issue:
12(1)
Published: Sept. 14, 2020
Abstract
Alzheimer’s
disease
(AD)
has
been
a
devastating
public
health
with
the
development
of
global
aging.
Approaches
for
reducing
current
AD
epidemic
are
becoming
primary
focus
human
healthcare
due
to
lack
achieved
lasting
and
complete
remission
strategies
treat
characteristics
heterogeneity
complexity.
Exosomes,
which
is
new
emerging
approach
intercellular
communication,
provide
novel
perspective
on
identified
therapeutic
AD.
Mesenchymal
stem
cell-derived
exosomes
(MSC-exos)
be
an
appealing
tool
AD,
donor-derived
properties
minimal
immunogenicity,
effortless
storage,
nature
delivery
vehicles,
low
risks
tumor
formation
based
previous
researches.
In
this
review,
we
elaborate
mechanism
MSC-exos
in
treatment
discuss
limitations
clinical
application.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2019,
Volume and Issue:
7
Published: Nov. 27, 2019
Effective
regeneration
of
bone
defects
often
presents
significant
challenges,
particularly
in
patients
with
decreased
tissue
capacity
due
to
extensive
trauma,
disease,
and/or
advanced
age.
A
number
studies
have
focused
on
enhancing
by
applying
mesenchymal
stromal
cells
(MSCs)
or
MSC-based
engineering
strategies.
However,
translation
these
approaches
from
basic
research
findings
clinical
use
has
been
hampered
the
limited
understanding
MSC
therapeutic
actions
and
complexities,
as
well
costs
related
manufacturing,
regulatory
approval,
living
engineered
tissues.
More
recently,
a
shift
view
MSCs
directly
contributing
towards
appreciating
"cell
factories"
that
secrete
variety
bioactive
molecules
extracellular
vesicles
trophic
immunomodulatory
activities
steered
into
new
MSC-based,
"cell-free"
modalities.
The
current
review
recapitulates
recent
developments,
future
perspectives
various
Stem Cell Research & Therapy,
Journal Year:
2020,
Volume and Issue:
11(1)
Published: April 28, 2020
Mesenchymal
stromal
cell
(MSC)-enriched
products
showed
positive
clinical
outcomes
in
regenerative
medicine,
where
tissue
restoration
and
inflammation
control
are
needed.
GMP-expanded
MSCs
displayed
an
even
higher
potential
due
to
exclusive
secretion
of
therapeutic
factors,
both
free
conveyed
within
extracellular
vesicles
(EVs),
collectively
termed
secretome.
Moreover,
priming
with
biochemical
cues
may
influence
the
portfolio
biological
activities
MSC-derived
factors.
For
these
reasons,
use
naive
or
primed
secretome
gained
attention
as
a
cell-free
option.
Albeit,
at
present,
homogenous
comprehensive
fingerprint
is
still
missing.
Therefore,
aim
this
work
was
deeply
characterize
adipose-derived
MSC
(ASC)-secreted
factors
EV-miRNAs,
their
modulation
after
IFNγ
preconditioning.
The
crucial
target
pathology
type
also
scored
osteoarthritis
evaluate
disease-driven
potency.
International Journal of Molecular Sciences,
Journal Year:
2019,
Volume and Issue:
20(20), P. 4987 - 4987
Published: Oct. 9, 2019
Tissue
engineering
and/or
regenerative
medicine
are
fields
of
life
science
exploiting
both
and
biological
fundamentals
to
originate
new
tissues
organs
induce
the
regeneration
damaged
or
diseased
organs.
In
particular,
de
novo
bone
tissue
requires
a
mechanically
competent
osteo-conductive/inductive
3D
biomaterial
scaffold
that
guarantees
cell
adhesion,
proliferation,
angiogenesis
differentiation
into
osteogenic
lineage.
Cellular
components
represent
key
factor
in
growth
strategies
take
advantage
from
employment
mesenchymal
stem
cells
(MSCs),
an
ideal
source
for
repair.
Recently,
application
extracellular
vesicles
(EVs),
isolated
cells,
as
cell-free
therapy
has
emerged
promising
therapeutic
strategy.
This
review
aims
at
summarizing
recent
representative
research
on
field
using
enriched
with
human
oral
their
derivatives,
EVs,
potential
reconstructing
defects.
Scientific Reports,
Journal Year:
2021,
Volume and Issue:
11(1)
Published: Jan. 18, 2021
Abstract
Mesenchymal
stromal/stem
cells
(MSCs)
are
characterized
by
neuroprotective,
immunomodulatory,
and
neuroregenerative
properties,
which
support
their
therapeutic
potential
for
inflammatory/neurodegenerative
diseases,
including
multiple
sclerosis
(MS)
amyotrophic
lateral
(ALS).
One
mode
of
action
through
MSCs
exert
immunomodulatory
effects
is
release
extracellular
vesicles
that
carry
proteins,
mRNAs,
microRNAs
(miRNAs),
which,
once
transferred,
modify
the
function
target
cells.
We
identified
nine
miRNAs
significantly
dysregulated
in
IFN-γ-primed
MSCs,
but
present
at
different
levels
derived
small
(s-EV).
show
miR-467f
miR-466q
modulate
pro-inflammatory
phenotype
activated
N9
microglia
primary
acutely
isolated
from
late
symptomatic
SOD1
G93A
mice,
a
murine
ALS
model,
downregulating
Tnf
Il1b
expression.
Further
analysis
indicated
they
dampen
modulating
p38
MAPK
signaling
pathway
via
inhibition
expression
genes,
Map3k8
Mk2.
Finally,
we
demonstrated
vivo
administration
s-EV
leads
to
decreased
neuroinflammation
markers
spinal
cord
EAE-affected
albeit
without
affecting
disease
course.
Overall,
our
data
suggest
MSC-derived
exosomes
could
affect
possibly
specific
acting
on
microglia.
Biomedicines,
Journal Year:
2021,
Volume and Issue:
9(8), P. 1061 - 1061
Published: Aug. 20, 2021
Exosomes
are
extracellular
vesicles
released
by
cells,
both
constitutively
and
after
cell
activation,
present
in
different
types
of
biological
fluid.
involved
the
pathogenesis
diseases,
such
as
cancer,
neurodegenerative
pregnancy
disorders
cardiovascular
have
emerged
potential
non-invasive
biomarkers
for
detection,
prognosis
therapeutics
a
myriad
diseases.
In
this
review,
we
describe
recent
advances
related
to
regulatory
mechanisms
exosome
biogenesis,
release
molecular
composition,
well
their
role
health
disease,
use
disease
therapeutic
targets.
addition,
advantages
disadvantages
main
isolation
methods,
characterization
cargo
analysis,
experimental
methods
used
exosome-mediated
drug
delivery,
discussed.
Finally,
perspectives
exosomes
future
clinical
practice.
