Sex/Gender-Specific Imbalance in CVD: Could Physical Activity Help to Improve Clinical Outcome Targeting CVD Molecular Mechanisms in Women? DOI Open Access
Mauro Vaccarezza, Verónica Papa, Daniela Milani

et al.

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(4), P. 1477 - 1477

Published: Feb. 21, 2020

In the last two decades, new insights have been gained regarding sex/gender-related differences in cardiovascular disease (CVD). CVD represents leading cause of death worldwide both men and women, accounting for at least one-third all deaths women half over 50 years developing countries. Important sex-related prevalence, presentation, management, outcomes different CVDs recently discovered, demonstrating sex/gender-specific pathophysiologic features presentation prognosis women. A large amount evidence has highlighted role sex hormones protecting from CVDs, providing an advantage that is lost when reach menopause stage. This hormonal-dependent shift risk consequently affects overall epidemiology, particularly light increasing trend population aging. The benefits physical activity recognized a long time as powerful preventive approach prevention aging-related morbidity control. Exercise training indeed potent physiological stimulus, which reduces primary secondary events. However, underlying mechanisms these positive effects, including sex/gender perspective, still need to be fully elucidated. aim this work provide review linking CVD, molecular mediators, explore whether sex- gender-tailored may used effective tool prevent improve clinical

Language: Английский

Autophagy in Its (Proper) Context: Molecular Basis, Biological Relevance, Pharmacological Modulation, and Lifestyle Medicine DOI Creative Commons
Miguel Á. Ortega, Oscar Fraile‐Martínez,

Diego De León-Oliva

et al.

International Journal of Biological Sciences, Journal Year: 2024, Volume and Issue: 20(7), P. 2532 - 2554

Published: Jan. 1, 2024

Autophagy plays a critical role in maintaining cellular homeostasis and responding to various stress conditions by the degradation of intracellular components.In this narrative review, we provide comprehensive overview autophagy's molecular basis, biological significance, pharmacological modulation, its relevance lifestyle medicine.We delve into intricate mechanisms that govern autophagy, including macroautophagy, microautophagy chaperone-mediated autophagy.Moreover, highlight significance autophagy aging, immunity, metabolism, apoptosis, tissue differentiation systemic diseases, such as neurodegenerative or cardiovascular diseases cancer.We also discuss latest advancements modulation their potential implications clinical settings.Finally, explore intimate connection between factors emphasizing how nutrition, exercise, sleep patterns environmental can significantly impact autophagic process.The integration medicine research opens new avenues for promoting health longevity through personalized interventions.

Language: Английский

Citations

6
Disturbed mitochondrial quality control involved in hepatocytotoxicity induced by silica nanoparticles DOI
Yi Qi, Ru Ma, Xueyan Li

et al.

Nanoscale, Journal Year: 2020, Volume and Issue: 12(24), P. 13034 - 13045

Published: Jan. 1, 2020

SiNPs triggered hepatocytotoxicity through interfering mitochondrial quality control process, including imbalanced dynamics, disturbed mitophagy and suppressed biogenesis, leading to dysfunction ensuing cell damage.

Language: Английский

Citations

45
Excessive ROS production and enhanced autophagy contribute to myocardial injury induced by branched-chain amino acids: Roles for the AMPK-ULK1 signaling pathway and α7nAChR DOI
Yujie Jiang, Sijia Sun, Wenxiang Cao

et al.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2020, Volume and Issue: 1867(1), P. 165980 - 165980

Published: Sept. 25, 2020

Language: Английский

Citations

44
The emerging role of skeletal muscle mitochondrial dynamics in exercise and ageing DOI
Rafael A. Casuso, Jesús R. Huertas

Ageing Research Reviews, Journal Year: 2020, Volume and Issue: 58, P. 101025 - 101025

Published: Feb. 1, 2020

Language: Английский

Citations

43
Sex/Gender-Specific Imbalance in CVD: Could Physical Activity Help to Improve Clinical Outcome Targeting CVD Molecular Mechanisms in Women? DOI Open Access
Mauro Vaccarezza, Verónica Papa, Daniela Milani

et al.

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(4), P. 1477 - 1477

Published: Feb. 21, 2020

In the last two decades, new insights have been gained regarding sex/gender-related differences in cardiovascular disease (CVD). CVD represents leading cause of death worldwide both men and women, accounting for at least one-third all deaths women half over 50 years developing countries. Important sex-related prevalence, presentation, management, outcomes different CVDs recently discovered, demonstrating sex/gender-specific pathophysiologic features presentation prognosis women. A large amount evidence has highlighted role sex hormones protecting from CVDs, providing an advantage that is lost when reach menopause stage. This hormonal-dependent shift risk consequently affects overall epidemiology, particularly light increasing trend population aging. The benefits physical activity recognized a long time as powerful preventive approach prevention aging-related morbidity control. Exercise training indeed potent physiological stimulus, which reduces primary secondary events. However, underlying mechanisms these positive effects, including sex/gender perspective, still need to be fully elucidated. aim this work provide review linking CVD, molecular mediators, explore whether sex- gender-tailored may used effective tool prevent improve clinical

Language: Английский

Citations

43