International Journal of Molecular Medicine,
Journal Year:
2021,
Volume and Issue:
48(2)
Published: June 15, 2021
To
date,
the
role
of
lncRNA
long
intergenic
non‑protein‑coding
RNA
1132
(LINC01132)
expression
in
epithelial
ovarian
cancer
(EOC)
has
not
been
explored.
Thus,
LINC01132
EOC
was
assessed
and
regulatory
activity
on
malignant
behaviours
cells
investigated.
Additionally,
molecular
events
that
occurred
downstream
were
also
revealed.
In
present
study,
verified
by
employing
RT‑qPCR.
The
effects
aggressive
revealed
utilizing
multiple
functional
experiments.
targeting
interaction
among
LINC01132,
microRNA‑431‑5p
(miR‑431‑5p)
SRY‑box
9
(SOX9)
demonstrated
immunoprecipitation
luciferase
reporter
assay.
Herein,
overexpressed
significantly
associated
with
poor
patient
prognosis.
Functionally,
cell
experiments
depletion
produced
cancer‑suppressive
regulated
proliferation,
migration,
invasion
apoptosis
in
vitro.
loss
attenuated
tumour
growth
vivo.
Mechanistically,
acted
as
a
competing
endogenous
sequestering
miR‑431‑5p
consequently
overexpressing
SOX9
cells,
forming
LINC01132/miR‑431‑5p/SOX9
axis.
rescue
experiments,
inhibition
or
reintroduction
eliminated
anti‑tumour
silencing
pathological
cells.
Generally,
exhibited
oncogenic
activities
regulating
outcome
miR‑431‑5p/SOX9
axis,
providing
an
effective
target
for
diagnosis,
therapy
prognosis
evaluation.
Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
13
Published: Jan. 18, 2023
Ovarian
cancer
is
a
malignant
tumor
of
the
female
reproductive
system,
with
very
poor
prognosis
and
high
mortality
rates.
Chemotherapy
radiotherapy
are
most
common
treatments
for
ovarian
cancer,
unsatisfactory
results.
Exosomes
subpopulation
extracellular
vesicles,
which
have
diameter
approximately
30–100
nm
secreted
by
many
different
types
cells
in
various
body
fluids.
highly
stable
effective
carriers
immunotherapeutic
drugs.
Recent
studies
shown
that
exosomes
involved
cellular
responses
microenvironment,
influencing
development
therapeutic
efficacy
exhibiting
dual
roles
inhibiting
promoting
development.
also
contain
variety
genes
related
to
immunotherapy
could
be
potential
biomarkers
diagnosis
prognosis.
Undoubtedly,
great
field
immunotherapy.
However,
translation
this
idea
clinic
has
not
occurred.
Therefore,
it
important
understand
how
used
regulate
progression.
In
review,
we
summarize
fluids
mechanisms
influence
response.
We
discuss
prospects
clinical
application
exosome-based
cancer.
Therapeutic Advances in Medical Oncology,
Journal Year:
2024,
Volume and Issue:
16
Published: Jan. 1, 2024
Ovarian
cancer
(OC)
is
the
most
lethal
gynaecologic
malignancy,
attributed
to
its
insidious
growth,
non-specific
symptoms
and
late
presentation.
Unfortunately,
current
screening
modalities
are
inadequate
at
detecting
OC
many
lack
appropriate
specificity
sensitivity
that
desired
from
a
test.
Nearly
70%
of
cases
diagnosed
stage
III
or
IV
with
poor
5-year
overall
survival.
Therefore,
development
sensitive
specific
biomarker
for
early
diagnosis
utmost
importance.
Currently,
guided
by
CA125,
patient’s
menopausal
status
imaging
features
on
ultrasound
scan.
However,
emerging
evidence
suggests
combination
CA125
HE4
(another
serum
biomarker)
patient
characteristics
in
multivariate
index
assay
may
provide
higher
than
either
alone
detection
OC.
Other
attempts
combining
various
biomarkers
into
one
such
as
OVA1,
ROMA
Overa
have
all
shown
promise.
significant
barriers
exist
before
these
can
be
implemented
clinical
practice.
This
article
aims
an
up-to-date
review
potential
which
transform
diagnostic
landscape.
Cancer Epidemiology Biomarkers & Prevention,
Journal Year:
2020,
Volume and Issue:
29(12), P. 2504 - 2512
Published: Oct. 13, 2020
Abstract
Early
detection
of
ovarian
cancer
remains
an
important
unmet
medical
need.
Effective
screening
could
reduce
mortality
by
10%–30%.
Used
individually,
neither
serum
CA125
nor
transvaginal
sonography
(TVS)
is
sufficiently
sensitive
or
specific.
Two-stage
strategies
have
proven
more
effective,
where
a
significant
rise
above
woman's
baseline
prompts
TVS
and
abnormal
sonogram
surgery.
Two
major
trials
documented
that
this
strategy
has
adequate
specificity,
but
sensitivity
for
early-stage
(I–II)
disease
must
improve
to
greater
impact
on
mortality.
To
the
first
stage,
different
panels
protein
biomarkers
detected
cases
missed
CA125.
Autoantibodies
against
TP53
20%
cancers
8
months
before
elevation
22
clinical
diagnosis.
Panels
autoantibodies
antigen–autoantibody
complexes
are
being
evaluated
with
goal
detecting
>90%
cancers,
alone
in
combination
CA125,
while
maintaining
98%
specificity
control
subjects.
Other
biomarkers,
including
micro-RNAs,
ctDNA,
methylated
DNA,
combinations
ctDNA
alterations,
tested
provide
optimal
first-stage
test.
New
technologies
also
developed
than
image
small
volumes
tumor.
See
all
articles
CEBP
Focus
section,
“NCI
Detection
Research
Network:
Making
Cancer
Possible.”
Molecular Therapy — Nucleic Acids,
Journal Year:
2020,
Volume and Issue:
23, P. 169 - 184
Published: Oct. 15, 2020
An
increasing
number
of
studies
have
clarified
the
functional
roles
RNA-binding
proteins
(RBPs)
in
driving
post-transcriptional
mechanisms
cancer
progression.
In
this
study,
we
integrated
data
from
RBP
database
and
Gene
Expression
Omnibus
(GEO)
with
RNA
sequencing
(RNA-seq)
10
ovarian
tissues
8
normal
identified
an
RBP,
CUGBP-
ETR-3-like
family
2
(CELF2).
We
found
that
CELF2
expression
was
downregulated
positively
correlated
overall
survival
(OS)
progression-free
(PFS)
patients
cancer.
Altered
led
to
changes
proliferation,
migration,
invasion
cells
Cancers,
Journal Year:
2021,
Volume and Issue:
13(18), P. 4608 - 4608
Published: Sept. 14, 2021
Cancer
is
a
leading
public
health
issue
globally,
and
diagnosis
often
associated
with
poor
outcomes
reduced
patient
survival.
One
of
the
major
contributors
to
fatality
resultant
cancer
development
resistance
chemotherapy,
known
as
chemoresistance.
Furthermore,
there
are
limitations
in
our
ability
identify
patients
that
will
respond
therapy,
versus
develop
relapse,
display
limited
or
no
response
treatment.
This
leads
being
subjected
multiple
futile
treatment
cycles,
results
reduction
their
quality
life.
Therefore,
an
urgent
clinical
need
tools
at
risk
chemoresistance,
recent
literature
has
suggested
small
extracellular
vesicles,
exosomes,
may
be
vital
source
information.
Extracellular
vesicles
(EV)
membrane
bound
involved
cell-cell
communication,
through
transfer
cargo,
which
includes
proteins,
lipids,
miRNAs.
A
defined
exploration
strategy
was
performed
this
systematic
review
order
provide
compilation
key
EV
miRNAs
predictive
We
searched
PubMed,
Science
Direct,
Scopus
databases
using
following
keywords:
OR
exosomes
EVs
AND
miRNA
Chemotherapy
Chemoresistance
Recurrence
from
2010
2020.
found
31
articles
reported
EV-associated
recurrence
related
Interestingly,
studies
same
tumor
type
identified
different
microRNAs,
few
ones.
Specifically,
miR-21,
miR-222,
miR-155
displayed
roles
were
common
colorectal
cancer,
ovarian
breast
diffuse
large
B
cell
lymphoma
(DLBCL).
miR-21
miR-222
favour
whereas
exhibited
contrasting
role,
depending
on
primary
tumor.
Whilst
high
levels
correlate
chemotherapy
DLBCL,
it
effective
towards
cancer.
Thus,
further
research
regarding
these
would
beneficial
terms
designing
novel
counteract
progression
not-to-distant
future.
Frontiers in Molecular Biosciences,
Journal Year:
2024,
Volume and Issue:
11
Published: April 16, 2024
Ovarian
cancer
is
one
of
the
most
aggressive
and
significant
malignant
tumor
forms
in
female
reproductive
system.
It
leading
cause
death
among
gynecological
cancers
owing
to
its
metastasis.
Since
preliminary
disease
symptoms
are
lacking,
it
imperative
develop
early
diagnostic
biomarkers
aid
treatment
optimization
personalization.
In
this
vein,
microRNAs,
which
short
sequence
non-coding
molecules,
displayed
great
potential
as
highly
specific
sensitive
biomarker.
miRNAs
have
been
extensively
advocated
proven
serve
an
instrumental
part
clinical
management
cancer,
especially
ovarian
by
promoting
cell
progression,
invasion,
delayed
apoptosis,
epithelial-mesenchymal
transition,
metastasis
cells,
chemosensitivity
resistance
therapy.
Here,
we
cover
our
present
comprehension
up-to-date
microRNA-based
approaches
detect
well
current
strategies,
role
microRNAs
oncogenes
or
suppressor
genes,
their
significance
prognosis,
International Journal of Molecular Sciences,
Journal Year:
2020,
Volume and Issue:
21(19), P. 7093 - 7093
Published: Sept. 25, 2020
Epithelial
ovarian
cancer
(EOC)
is
the
deadliest
gynecological
cancer,
and
major
cause
of
death
mainly
attributed
to
metastasis.
MicroRNAs
(miRNAs)
are
a
group
small
non-coding
RNAs
that
exert
important
regulatory
functions
in
many
biological
processes
through
their
effects
on
regulating
gene
expression.
In
most
cases,
miRNAs
interact
with
3′
UTRs
target
mRNAs
induce
degradation
suppress
translation.
Aberrant
expression
has
been
detected
EOC
tumors
and/or
fluids
patients.
Such
dysregulation
occurs
as
result
alterations
DNA
copy
numbers,
epigenetic
regulation,
miRNA
biogenesis.
Many
studies
have
demonstrated
can
promote
or
events
related
metastasis,
such
cell
migration,
invasion,
epithelial-to-mesenchymal
transition,
interaction
tumor
microenvironment.
this
review,
we
provide
brief
overview
biogenesis
highlight
some
key
regulations
We
summarize
current
knowledge
how
dysregulated,
focusing
those
reported
regulate
Furthermore,
discuss
role
promoting
inhibiting
Finally,
point
out
limitations
findings
suggest
future
research
directions
field.
Cancers,
Journal Year:
2020,
Volume and Issue:
12(11), P. 3455 - 3455
Published: Nov. 20, 2020
MicroRNAs
(miRNAs)
are
released
by
different
types
of
cells
through
highly
regulated
mechanisms
under
normal
and
pathological
conditions.
These
extracellular
miRNAs
can
be
delivered
into
recipient
for
functional
purposes,
acting
as
cell-to-cell
signaling
mediators.
It
has
been
discovered
that
cancer
release
their
surroundings,
targeting
or
other
cells,
presumably
to
promote
tumor
development
progression.
associated
with
oncogenic
and,
because
they
quantified
in
blood
bodily
fluids,
may
suitable
noninvasive
biomarkers
detection.
This
review
summarizes
recent
evidence
the
role
intercellular
mediators,
an
emphasis
on
progression
potential
value
solid
tumors.
also
highlights
biological
characteristics
enable
them
function
regulators
gene
expression,
such
biogenesis,
silencing
mechanisms,
subcellular
compartmentalization,
functions
release.