Mechanistic insights into heat shock protein 27, a potential therapeutic target for cardiovascular diseases

Frontiers in Cardiovascular Medicine, Journal Year: 2023, Volume and Issue: 10

Published: May 12, 2023

Heat shock protein 27 (HSP27) is a small chaperone that overexpressed in variety of cellular stress states. It involved regulating proteostasis and protecting cells from multiple sources injury by stabilizing conformation promoting the refolding misfolded proteins. Previous studies have confirmed HSP27 development cardiovascular diseases plays an important regulatory role this process. Herein, we comprehensively systematically summarize involvement its phosphorylated form pathophysiological processes, including oxidative stress, inflammatory responses, apoptosis, further explore potential mechanisms possible roles diagnosis treatment diseases. Targeting promising future strategy for

Language: Английский

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Ginseng-derived compounds as potential anticancer agents targeting cancer stem cells

Journal of Ginseng Research, Journal Year: 2024, Volume and Issue: 48(3), P. 266 - 275

Published: March 12, 2024

Cancer stem cells (CSCs) are a rare subpopulation of cancer that exhibit cell-like characteristics, including self-renewal and differentiation in multi-stage lineage state via symmetric or asymmetric division, causing tumor initiation, heterogeneity, progression, recurrence posing major challenge to current anticancer therapy. Despite the importance CSCs carcinogenesis currently available therapeutics have limitations for eradicating CSCs. Moreover, efficacy therapeutic windows anti-CSC agents limited, suggesting necessity optimize develop novel agent targeting Ginseng has been traditionally used enhancing immunity relieving fatigue. As ginseng's long history use demonstrated its safety, it gained attention potential pharmacological properties, effects. Several studies identified bioactive principles ginseng, such as ginseng saponin (ginsenosides) non-saponin compounds (e.g., polysaccharides, polyacetylenes, phenolic compounds), their activities, antioxidant, anticancer, antidiabetic, antifatigue, neuroprotective Notably, recent reports shown ginseng-derived agents. This review investigates biology efforts utilize components treatment CSCs, highlighting role overcoming limitations.

Language: Английский

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The missing link between cancer stem cells and immunotherapy

Current Medical Research and Opinion, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 35

Published: Sept. 24, 2024

Cancer stem cells (CSCs) are cancer that can self-renew and give rise to tumors. The multipotency of CSCs enables the generation diverse cell types their potential for differentiation resilience against chemotherapy radiation. Additionally, specific biomarkers have been identified them, such as CD24, CD34, CD44, CD47, CD90, CD133. CSC model suggests a subset within tumors is responsible tumor growth. microenvironment (TME), including Fibroblasts, immune cells, adipocytes, endothelial neuroendocrine (NE) extracellular matrix (ECM), vesicles, has part in shielding from host response well protecting them anticancer drugs. regulation plasticity by cancer-associated fibroblasts (CAFs) occurs through signaling pathways differ among various cancer, utilizing IGF-II/IGF1R, FAK, c-Met/FRA1/HEY1 pathways. Due intricate dynamics proliferation, controlling growth necessitates innovative approaches much more research. Our current review speculates an outline how TME safeguards interaction with CSCs, involvement inflammatory systems maintenance. Several technologies ability identify CSCs; however, each approach limitations. We discuss these methods aid recognizing several types, comprising brain, breast, liver, stomach, colon cancer. Furthermore, we explore different immunotherapeutic strategies targeting stimulating cancer-specific T modifying immunosuppressive TMEs, antibody-mediated therapy markers.

Language: Английский

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Oncomatrix: Molecular Composition and Biomechanical Properties of the Extracellular Matrix in Human Tumors

Journal of Molecular Pathology, Journal Year: 2024, Volume and Issue: 5(4), P. 437 - 453

Published: Oct. 5, 2024

The extracellular matrix is an organized three-dimensional network of protein-based molecules and other macromolecules that provide structural biochemical support to tissues. Depending on its properties, the influences cell adhesion signal transduction and, in general, can influence differentiation proliferation through specific mechanisms chemical mechanical sensing. development body tissues during ontogenesis accompanied by changes not only cells but also composition properties matrix. Similarly, tumor carcinogenesis a continuous change cells, called ‘oncomatrix’, as matures, from primary focus stage metastasis. In this paper, characteristics are considered, well evolution patterns be used biomarkers oncological diseases potential targets for promising anti-tumor therapies.

Language: Английский

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Mitochondrial chaperones in human health and disease

Free Radical Biology and Medicine, Journal Year: 2021, Volume and Issue: 179, P. 363 - 374

Published: Nov. 12, 2021

Language: Английский

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