Self‐Assembly of Noncanonical Peptides: A New Frontier in Cancer Therapeutics and Beyond DOI Creative Commons
Lin Bai, Meihui Yi, Bing Xu

et al.

Macromolecular Bioscience, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

Abstract In addition to the 20 standard amino acids that form building blocks of proteins, nature employs alternative create specialized “noncanonical peptides.” These unique peptides, found in organisms from bacteria humans, often exhibit unconventional structures and functionalities, playing critical roles modulating cellular processes, particularly as antibiotics. Their potential has attracted significant interest for designing novel functional materials based on noncanonical peptides. This review highlights recent advances generation application peptide assemblies. It begins with a definition including classic examples showcase their distinct useful biological activities. Then applications assemblies developing anticancer therapeutics are discussed, focusing representative studies demonstrate efficacy versatility targeting tumor cells. Beyond oncology, it is explored how have been utilized biomaterials, regenerative medicine, molecular imaging catalysis. Finally, perspectives offered future directions this rapidly evolving field, emphasizing exciting opportunities remaining challenges will drive continued innovation applying peptide‐based

Language: Английский

Self‐Assembly of Noncanonical Peptides: A New Frontier in Cancer Therapeutics and Beyond DOI Creative Commons
Lin Bai, Meihui Yi, Bing Xu

et al.

Macromolecular Bioscience, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

Abstract In addition to the 20 standard amino acids that form building blocks of proteins, nature employs alternative create specialized “noncanonical peptides.” These unique peptides, found in organisms from bacteria humans, often exhibit unconventional structures and functionalities, playing critical roles modulating cellular processes, particularly as antibiotics. Their potential has attracted significant interest for designing novel functional materials based on noncanonical peptides. This review highlights recent advances generation application peptide assemblies. It begins with a definition including classic examples showcase their distinct useful biological activities. Then applications assemblies developing anticancer therapeutics are discussed, focusing representative studies demonstrate efficacy versatility targeting tumor cells. Beyond oncology, it is explored how have been utilized biomaterials, regenerative medicine, molecular imaging catalysis. Finally, perspectives offered future directions this rapidly evolving field, emphasizing exciting opportunities remaining challenges will drive continued innovation applying peptide‐based

Language: Английский

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