Acetaminophen effects upon formalin-evoked flinching, postformalin, and postincisional allodynia and conditioned place preference DOI Creative Commons
Mi-Jung Yun,

Naemi Ditlevsen Regen,

Yuvicza Anchondo

et al.

PAIN Reports, Journal Year: 2024, Volume and Issue: 9(5), P. e1168 - e1168

Published: Aug. 12, 2024

Abstract Introduction: We explored in mice, the analgesic, tolerance, dependency, and rewarding effects of systemic acetaminophen (APAP). Methods: Studies employed adult mice (C57Bl6). (1) Intraplantar formalin flinching + post allodynia . Mice were given intraperitoneal APAP a DMSO (5%)/Tween 80 (5%) or water-based formulation before on day 1 tactile thresholds assessed after at 12. (2) Paw incision. At 24 hours 8 days hind paw incision male assessed. (3) Repeated delivery received daily (4 days) analgesic doses vehicle tested upon 5. (4) Conditioned place preference For 3 consecutive days, was morning either 2 chambers each afternoon, an dose morphine other chamber. On 5 10, animals allowed to select “preferred” Results: Formalin resulted biphasic enduring postformalin allodynia. Acetaminophen dependently decreased phase flinching, reversed observed postflinching. comparable dose, female showed similarly reduced flinching. Incision transiently by APAP. no loss effect sequential injections signs withdrawal. Morphine, but not vehicle, robust preference. Conclusions: following absence dependence, properties.

Language: Английский

Use of a generic Paediatric Patient Reported Outcome Measure (P-PROM) in Routine hospital Outpatient Care for Kids (ROCK): A qualitative exploration of adolescent, caregiver and service provider perspectives (P-PROM ROCK Phase 1) DOI Creative Commons
Renee Jones, Kim Dalziel, Harriet Hiscock

et al.

Quality of Life Research, Journal Year: 2025, Volume and Issue: unknown

Published: May 14, 2025

Language: Английский

Citations

0
Modification of sodium montmorillonite by two quaternary ammonium surfactants with different chain lengths: Preparation, characterization and adsorption of acetaminophen DOI
Hao Gao, Xiaoping Xing,

Yuting Chu

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: unknown, P. 141149 - 141149

Published: Dec. 1, 2024

Language: Английский

Citations

1
Evaluating the Role of Susceptibility Inducing Cofactors and of Acetaminophen in the Etiology of Autism DOI Open Access

John P. Jones,

Lauren Williamson,

Zacharoula Konsoula

et al.

Published: June 4, 2024

More than 20 lines of independent evidence from clinical observations, studies in laboratory animal models, pharmacokinetic considerations, and numerous temporal spatial associations previously indicate that genetic environmental factors leading to inflammation oxidative stress confer vulnerability aberrant metabolism acetaminophen during early development, autism spectrum disorder (ASD). Contrary this conclusion, multivariate analyses cohort data adjusting for inflammation-associated have tended show little no risk use neurodevelopment. To resolve discrepancy, here we in-silico methods create an ideal (virtual) population 120000 individuals which 50% all cases virtual ASD are induced by stress-associated cofactors use. We demonstrate Cox regression analysis set shows if adjusted the analysis. Further, under-reporting is shown be a considerable problem analysis, large erroneously low calculated risks In addition, argue impart susceptibility acetaminophen-induced injury, propensity itself, can shared between prepartum, peripartum, postpartum periods, creating additional difficulty existing datasets determine exposure neurodevelopment specific time frame. It concluded obtained depend on underlying assumptions analyses, other evidence, both abundant robust, critical role etiology ASD.

Language: Английский

Citations

1
Evaluating the Role of Susceptibility Inducing Cofactors and of Acetaminophen in the Etiology of Autism Spectrum Disorder DOI Creative Commons
John Paul Jones,

Lauren Williamson,

Zacharoula Konsoula

et al.

Life, Journal Year: 2024, Volume and Issue: 14(8), P. 918 - 918

Published: July 23, 2024

More than 20 previously reported lines of independent evidence from clinical observations, studies in laboratory animal models, pharmacokinetic considerations, and numerous temporal spatial associations indicate that genetic environmental factors leading to inflammation oxidative stress confer vulnerability the aberrant metabolism acetaminophen during early development, autism spectrum disorder (ASD). Contrary this conclusion, multivariate analyses cohort data adjusting for inflammation-associated have tended show little no risk use neurodevelopment. To resolve discrepancy, here we silico methods create an ideal (virtual) population 120,000 individuals which 50% all cases virtual ASD are induced by stress-associated cofactors use. We demonstrate Cox regression analysis dataset shows if adjusted analysis. Further, under-reporting is shown be a considerable problem analysis, large erroneously low calculated risks In addition, argue impart susceptibility acetaminophen-induced injury, propensity itself, can shared between prepartum, peripartum, postpartum periods, creating additional difficulty existing datasets determine exposure neurodevelopment specific time frame. It concluded obtained depend on underlying assumptions analyses, other evidence, both abundant robust, critical role etiology ASD.

Language: Английский

Citations

1
Modification of Sodium Montmorillonite by Two Quaternary Ammonium Surfactants with Different Chain Lengths: Preparation, Characterization and Adsorption of Acetaminophen DOI
Hao Gao, Xiaoping Xing,

Yuting Chu

et al.

Published: Jan. 1, 2024

Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI

Language: Английский

Citations

0
Monokausale Erklärungsansätze zum Autismus verdienen große Skepsis DOI
Daniel Tibussek,

Martin Claßen

Pädiatrie, Journal Year: 2024, Volume and Issue: 36(2), P. 23 - 24

Published: April 1, 2024

Citations

0
Modification of Sodium Montmorillonite by Two Quaternary Ammonium Surfactants with Different Chain Lengths: Preparation, Characterization and Adsorption of Acetaminophen DOI
Hao Gao, Xiaoping Xing,

Yuting Chu

et al.

Published: Jan. 1, 2024

The objective of this study is to synthesize and characterize two types organic montmorillonites, namely H-Mt O-Mt, through the modification sodium montmorillonite (Na-Mt) using quaternary ammonium salt surfactants, specifically hexadecyl dimethyl benzyl chloride (HDBAC) octadecyl (ODBAC). And application O-Mt as acetaminophen (PCT), an adsorbent for emerging pharmaceutical contaminant, in wastewater treatment was investigated. Fourier transform infrared spectroscopy (FTIR) X-ray diffractometer (XRD) results demonstrated successful intercalation both modifiers into Na-Mt. intermittent adsorption experiments that optimal dosages were 1.6 CEC 1.0 (CEC cation exchange capacity Na-Mt), respectively. saturated capacities PCT reached 25.91 mg/g (H-Mt) 14.71 (O-Mt) at pH 5, respectively, while original Na-Mt exhibited a significantly lower only 0.77 mg/g. Additionally, it observed on inferior H-Mt, suggesting longer alkyl hydrocarbon chain has larger steric hindrance during process, which prevents from entering site montmorillonite. by Mt more accurately described pseudo-second-order kinetic model Freundlich isotherm equation. negative ΔG○ values ΔH○ determined thermodynamic parameters confirmed spontaneous exothermic process. present validated potential functionalized with HDBAC ODBAC highly effective contaminant.

Language: Английский

Citations

0
Acetaminophen effects upon formalin-evoked flinching, postformalin, and postincisional allodynia and conditioned place preference DOI Creative Commons
Mi-Jung Yun,

Naemi Ditlevsen Regen,

Yuvicza Anchondo

et al.

PAIN Reports, Journal Year: 2024, Volume and Issue: 9(5), P. e1168 - e1168

Published: Aug. 12, 2024

Abstract Introduction: We explored in mice, the analgesic, tolerance, dependency, and rewarding effects of systemic acetaminophen (APAP). Methods: Studies employed adult mice (C57Bl6). (1) Intraplantar formalin flinching + post allodynia . Mice were given intraperitoneal APAP a DMSO (5%)/Tween 80 (5%) or water-based formulation before on day 1 tactile thresholds assessed after at 12. (2) Paw incision. At 24 hours 8 days hind paw incision male assessed. (3) Repeated delivery received daily (4 days) analgesic doses vehicle tested upon 5. (4) Conditioned place preference For 3 consecutive days, was morning either 2 chambers each afternoon, an dose morphine other chamber. On 5 10, animals allowed to select “preferred” Results: Formalin resulted biphasic enduring postformalin allodynia. Acetaminophen dependently decreased phase flinching, reversed observed postflinching. comparable dose, female showed similarly reduced flinching. Incision transiently by APAP. no loss effect sequential injections signs withdrawal. Morphine, but not vehicle, robust preference. Conclusions: following absence dependence, properties.

Language: Английский

Citations

0