Role of Lung Ultrasound in the Detection of Lung Sequelae in Post-COVID-19 Patients: A Systematic Review and Meta-Analysis DOI Open Access
Andrea Boccatonda, Damiano D’Ardes,

Viola Tallarico

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(18), P. 5607 - 5607

Published: Sept. 21, 2024

Background: During the COVID-19 pandemic, several studies demonstrated effectiveness of lung ultrasound (LUS) as a frontline tool in diagnosing and managing acute SARS-CoV-2 pneumonia. However, its role detecting post-COVID-19 sequelae remains to be fully determined. This study aims evaluate diagnostic accuracy LUS identifying parenchymal damage, particularly fibrotic-like changes, following pneumonia, comparing performance that CT. Methods: Relevant published before July 2024 were identified through comprehensive search PubMed, Embase, Cochrane library. The terms combinations relevant medical subject heading (MeSH) terms, key words word variants for “lung”, “post-COVID”, “long-COVID”, “ultrasound”. pooled sensitivity, specificity, odds ratio (DOR), summary receiver-operating characteristic (SROC) curve used examine CEUS. selected works different thresholds detection counting B-lines by ultrasound. led dividing our analysis into two models, first based on lower found works, second data obtained using higher threshold. Results: In residual changes patients infection, low-threshold model displayed sensitivity 0.98 [95% confidence interval (CI): 0.95–0.99] specificity 0.54 (95% CI: 0.49–0.59). DOR was 44.9 10.8–187.1). area under (AUC) SROC 0.90. analysis, with threshold detect showed 0.90 0.85–0.94) 0.88 0.84–0.91). 50.4 15.9–159.3). AUC 0.93. Conclusions: both analyses (even high B-lines), excellent (98% 1 90% 2) is maintained. has significant variation between models from 54 (model 1) 87% 2). highest best accuracy, confirmed values (0.93).

Language: Английский

Long COVID in Children and Adolescents: Mechanisms, Symptoms, and Long-Term Impact on Health—A Comprehensive Review DOI Open Access
Diana-Georgiana Basaca, Iulius Jugănaru,

Oana Belei

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(2), P. 378 - 378

Published: Jan. 9, 2025

Long COVID, also known as post-acute sequelae of SARS-CoV-2 infection (PASC), is increasingly recognized a condition affecting not only adults but children and adolescents. While often experience milder acute COVID-19 symptoms compared to adults, some develop persistent physical, psychological, neurological lasting for weeks or months after initial infection. The most commonly reported include debilitating fatigue, respiratory issues, headaches, muscle pain, gastrointestinal disturbances, cognitive difficulties, which significantly impact daily activities, schooling, social interactions. Additionally, many with long COVID psychological symptoms, such anxiety, depression, mood swings, irritability, likely exacerbated by prolonged illness lifestyle disruptions. Risk factors in pre-existing health conditions asthma, obesity, disorders, adolescents females seemingly more affected. Hypothesized mechanisms underlying chronic immune dysregulation, viral particles stimulating inflammation, autonomic nervous system dysfunction, mitochondrial impairment, may collectively contribute the variety observed symptoms. Long-term outcomes remain uncertain; however, can lead school absenteeism, withdrawal, distress, potentially development. Severe cases postural orthostatic tachycardia syndrome (POTS) reduced exercise tolerance. This review synthesizes existing literature on children, examining its prevalence, symptomatology, risk factors, potential mechanisms, an emphasis need further clinical studies. research largely relies surveys self-reported data, assessments are essential accurately characterize pediatric populations guide effective management strategies.

Language: Английский

Citations

5
Retrospective Study of the Impact of SARS-CoV-2 Infection on Asthma Control in Children DOI Open Access
Jaqueline Abdul-Razzak, Mihaela Ionescu,

Radu Diaconu

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(2), P. 356 - 356

Published: Jan. 9, 2025

Asthmatic children who tested positive for COVID-19 experienced changes in lung function and persistent symptoms following SARS-CoV-2 infection, even several months after diagnosis, with the same features as an acute phase. This study aimed to analyze a pediatric age group (between 0 17 years old) diagnosed asthma, infection attending regular monitoring visits Pediatric Department of Regional Tertiary Hospital (Filantropia Clinical Municipal Craiova, Romania) during pandemic post-pandemic time interval (i.e., March 2020-July 2024), identify how influenced their long-term treatment. Materials Methods. The variables were recorded: demographic data (gender, group, residence), related allergies (allergic rhinitis, atopic dermatitis, food allergies), presence exacerbations, fraction exhaled nitric oxide, ventilatory function, asthma phenotype or non-allergic), well GINA assessment control at clinical analyzed. infections evaluated terms year symptoms, cough persistence, modifications treatment disease. statistically analyzed SPSS, using Mann-Whitney U, Kruskal-Wallis H, Chi-Square tests. Results. A lower incidence cases was recorded first asthmatic patients (2020 2021), but increase rate observed beginning second pandemic, 2022. oxide values infected significantly increased (p < 0.0005), especially more than 4 weeks. significant number exacerbations also 0.0005). Ventilatory different without 0.05). Conclusions. persistence phase tests emphasize need periodic medical check-ups, implementation therapeutic regimen appropriate each patient.

Language: Английский

Citations

1
Effects of Early-Life Air Pollution Exposure on Childhood COVID-19 Infection and Sequelae in China DOI
Chan Lu,

Wen Deng,

Zipeng Qiao

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 137940 - 137940

Published: March 1, 2025

Language: Английский

Citations

0
Treatment of Severe Asthma: Case Report of Fast Action of Mepolizumab in a Patient with Recent SARS-CoV-2 Infection DOI Creative Commons
Cristiana Indolfi, Giulio Dinardo, Angela Klain

et al.

Life, Journal Year: 2024, Volume and Issue: 14(9), P. 1063 - 1063

Published: Aug. 25, 2024

Asthma is one of the most common chronic inflammatory diseases childhood with a heterogeneous impact on health and quality life. Mepolizumab an antagonist interleukin-5, indicated as adjunct therapy for severe refractory eosinophilic asthma in adolescents children aged >6 years old. We present case 9 year-old boy who experienced several asthmatic exacerbations following SARS-CoV-2 infection, necessitating short-acting bronchodilators, oral corticosteroids, hospitalization. follow patient using validated questionnaires evaluation control: Children Control Test, Questionnaire, respiratory function tests, exhaled nitric oxide fraction. After 12 weeks from start mepolizumab, we found significant improvements lung function, reduction degree bronchial inflammation, No have been reported since initiation treatment mepolizumab. Respiratory infections, such those related to SARS-CoV-2, represent risk factor patients moderate forms asthma. In our experience, new episodes exacerbation, mepolizumab has allowed us improve control enhance life first doses. Although showed promise this child during results single cannot be generalized. Further studies are needed confirm its safety effectiveness.

Language: Английский

Citations

1
Lung Ultrasound Efficacy in Monitoring Post-SARS-CoV-2 Pneumonia and Inflammatory Biomarkers in Pediatric Patients DOI Creative Commons
R. Chelcea, Mihaela Dediu,

Diana Dabica

et al.

Medicina, Journal Year: 2024, Volume and Issue: 60(8), P. 1296 - 1296

Published: Aug. 11, 2024

Background and Objectives: Recognizing the crucial gaps in our understanding of pediatric pneumonia post-SARS-CoV-2 infection, this study aimed to assess relationship between Pediatric Pneumonia Ultrasound Scores (PedPne) inflammatory biomarkers. The primary objective is evaluate predictive value PedPne comparison with biomarkers (IL-6 dNLR) for development patients following SARS-CoV-2 infection. Materials Methods: This longitudinal observational collected data from diagnosed after an acute SARS-CoV2 focused on analyzing changes scores markers such as IL-6 dNLR initial admission follow-up at 7 days. Statistical analysis involved calculating sensitivity, specificity, Area Under Curve (AUC) each biomarker, alongside regression determine their hazard ratios predicting development. Results: identified significant cutoff values 1.88 (sensitivity 77.0%, specificity 85.7%, AUC 0.802, p < 0.001), 6.1 pg/mL 70.3%, 92.9%, 0.869, score 3.3 75.7%, 78.6%, 0.794, 0.001). Conversely, NLR showed lower diagnostic performance (AUC 0.485, = 0.327). Regression further highlighted strong power these markers, showing a fourfold increase risk (HR 4.25, CI: 2.07–9.53, indicating more than twofold 2.53, 1.19–6.97, 0.006), associated doubling 2.60, 1.33–5.18, Conclusions: conclusively demonstrated that both ultrasound specific are predictors post-COVID-19 These findings advocate integration routine clinical assessments enhance accuracy management children

Language: Английский

Citations

0
Role of Lung Ultrasound in the Detection of Lung Sequelae in Post-COVID-19 Patients: A Systematic Review and Meta-Analysis DOI Open Access
Andrea Boccatonda, Damiano D’Ardes,

Viola Tallarico

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(18), P. 5607 - 5607

Published: Sept. 21, 2024

Background: During the COVID-19 pandemic, several studies demonstrated effectiveness of lung ultrasound (LUS) as a frontline tool in diagnosing and managing acute SARS-CoV-2 pneumonia. However, its role detecting post-COVID-19 sequelae remains to be fully determined. This study aims evaluate diagnostic accuracy LUS identifying parenchymal damage, particularly fibrotic-like changes, following pneumonia, comparing performance that CT. Methods: Relevant published before July 2024 were identified through comprehensive search PubMed, Embase, Cochrane library. The terms combinations relevant medical subject heading (MeSH) terms, key words word variants for “lung”, “post-COVID”, “long-COVID”, “ultrasound”. pooled sensitivity, specificity, odds ratio (DOR), summary receiver-operating characteristic (SROC) curve used examine CEUS. selected works different thresholds detection counting B-lines by ultrasound. led dividing our analysis into two models, first based on lower found works, second data obtained using higher threshold. Results: In residual changes patients infection, low-threshold model displayed sensitivity 0.98 [95% confidence interval (CI): 0.95–0.99] specificity 0.54 (95% CI: 0.49–0.59). DOR was 44.9 10.8–187.1). area under (AUC) SROC 0.90. analysis, with threshold detect showed 0.90 0.85–0.94) 0.88 0.84–0.91). 50.4 15.9–159.3). AUC 0.93. Conclusions: both analyses (even high B-lines), excellent (98% 1 90% 2) is maintained. has significant variation between models from 54 (model 1) 87% 2). highest best accuracy, confirmed values (0.93).

Language: Английский

Citations

0