Research advances in gut microbes and autism spectrum disorders DOI Creative Commons

Renardo Lico

Published: Dec. 7, 2024

This paper concludes that recent research on the interrelationship between gut microbiota and autism spectrum disorder (ASD) has gained significant attention. The study found composition of in ASD patients is often markedly different from general population, particularly species abundance beneficial bacteria, such as Bifidobacterium Lactobacillus, which are frequently imbalanced. imbalance intestinal microorganisms not only affects health but also disrupts neurological functions mediated by gut-brain axis, exacerbating behavioral cognitive symptoms associated with ASD. In years, microbial interventions, including probiotics, prebiotics, fecal transplantation (FMT), have shown some promise. use probiotics prebiotics can increase proportion flora ASD, helping to produce anti-inflammatory short-chain fatty acids, thereby improving symptoms. Additionally, FMT, involves transplanting microbes healthy individuals into patients, demonstrated improvements both several studies. However, due high individual variability among a single intervention consistently effective across all individuals. Some respond well or whereas others show limited symptom improvement. may be attributed each patient's unique composition, immune status, metabolic profile. Therefore, further needed identify biomarkers predict effectiveness enabling more precise individualised therapies. review aims provide guidance for future offer theoretical foundation data support exploring modulation potential treatment

Language: Английский

Effect of Therapeutic Diet Along with Special Physiotherapy Program on Gross Motor Development and Cognitive Function in Autistic Children: A Randomized Controlled Trial DOI Creative Commons
Abdulrahman A. Alsayegh,

Azza A. Al Areefy,

Mohamed M. Ahmed

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: 4(1)

Published: Jan. 1, 2025

Children with autism spectrum disorder (ASD) experience negative effects on their everyday activities due to cognitive and motor disabilities. Physiotherapy treatment plans aim reduce body structure function impairments, promote developmental sequence, facilitate milestones, while gluten-free casein-free (GFCF) diets have been proven effective in improving symptoms. So, the purpose of this study was investigate effect a combined GFCF diet neurodevelopmental (NDT) physical therapy program gross development cognition children ASDs. Eighty ASD were distributed into four groups: A, for intervention; B, therapy; C, D control group. The evaluation performed using functional measures Stanford–Binet V5 before after intervention. Intervention continued 3 months Jazan region, Kingdom Saudi Arabia. Group A showed non-significant change both ( P = 0.89) 0.53) functions, Groups B C revealed significant improvement [mean difference (MD) −12.77, 14.61] (MD −14.2, 14.55), respectively, 0.001), finally no 0.65) 0.16). Gross significantly improved combination NDT program, alone cognition, had change.

Language: Английский

Citations

0
Nutritional management and autism spectrum disorder: A systematic review DOI Open Access
Mohammed Al‐Beltagi

World Journal of Clinical Pediatrics, Journal Year: 2024, Volume and Issue: 13(4)

Published: Oct. 30, 2024

BACKGROUND Autism spectrum disorder (ASD) presents unique challenges related to feeding and nutritional management. Children with ASD often experience difficulties, including food selectivity, refusal, gastrointestinal issues. Various interventions have been explored address these challenges, dietary modifications, vitamin supplementation, therapy, behavioral interventions. AIM To provide a comprehensive overview of the current evidence on management in ASD. We examine effectiveness interventions, supplements, mealtime practices addressing needs children METHODS systematically searched relevant literature up June 2024, using databases such as PubMed, PsycINFO, Scopus. Studies were included if they investigated or strategies improve behaviors assessed quality studies synthesized findings impact various difficulties outcomes. Data extraction focused intervention types, study designs, participant characteristics, outcomes measured, effectiveness. RESULTS The review identified 316 that met inclusion criteria. indicates while supplements may offer benefits managing specific symptoms deficiencies, approaches varies. Feeding therapy gradual exposure positive reinforcement, promise acceptance behaviors. also highlight importance creating supportive environments tailored sensory CONCLUSION Nutritional for requires multifaceted approach includes strategies. underscores need personalized further research refine treatment protocols Collaborative efforts among healthcare providers, educators, families are essential optimize this population's health practices. Enhancing our understanding sustainability long-term is optimizing care improving life their families.

Language: Английский

Citations

2
Microbiota and Autism: A Review on Oral and Gut Microbiome Analysis Through 16S rRNA Sequencing DOI Creative Commons

Federico Anaclerio,

M. Minelli,

Ivana Antonucci

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2686 - 2686

Published: Nov. 25, 2024

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with multifactorial etiologies, including genetic, environmental, and microbiological factors. In recent years, increasing attention has been given to the role of gut microbiota in ASD. Emerging evidence suggests that dysbiosis may influence central nervous system through gut-brain axis, potentially impacting behavior neurodevelopment. The use 16S rRNA gene sequencing become pivotal tool profiling microbial communities associated ASD, offering valuable insights into bacterial diversity, composition, potential functional roles. This review aims provide comprehensive analysis current findings on relationship between oral particular focus studies utilizing sequencing. We will explore how microbiome alterations contribute ASD pathophysiology, discuss limitations existing research, propose future directions for integration diagnostics treatment strategies. These underscore modulating symptoms. data suggest specific taxa are consistently altered which have implications understanding axis its

Language: Английский

Citations

1
Research advances in gut microbes and autism spectrum disorders DOI Creative Commons

Renardo Lico

Published: Dec. 7, 2024

This paper concludes that recent research on the interrelationship between gut microbiota and autism spectrum disorder (ASD) has gained significant attention. The study found composition of in ASD patients is often markedly different from general population, particularly species abundance beneficial bacteria, such as Bifidobacterium Lactobacillus, which are frequently imbalanced. imbalance intestinal microorganisms not only affects health but also disrupts neurological functions mediated by gut-brain axis, exacerbating behavioral cognitive symptoms associated with ASD. In years, microbial interventions, including probiotics, prebiotics, fecal transplantation (FMT), have shown some promise. use probiotics prebiotics can increase proportion flora ASD, helping to produce anti-inflammatory short-chain fatty acids, thereby improving symptoms. Additionally, FMT, involves transplanting microbes healthy individuals into patients, demonstrated improvements both several studies. However, due high individual variability among a single intervention consistently effective across all individuals. Some respond well or whereas others show limited symptom improvement. may be attributed each patient's unique composition, immune status, metabolic profile. Therefore, further needed identify biomarkers predict effectiveness enabling more precise individualised therapies. review aims provide guidance for future offer theoretical foundation data support exploring modulation potential treatment

Language: Английский

Citations

0