Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 22, 2025

Although remifentanil (RF) is not approved for use in the ICU children, its short half-life and titratability may provide advantages children requiring high doses of sedatives analgesics during prolonged mechanical ventilation. This report presents two pediatric cases which RF was administered sedation analgesia, enabling successful extubation without adverse effects. In Case 1, a four-year-old girl with multiple atypical teratoid rhabdoid tumors required ventilation due to impaired consciousness. initiated at 0.22 μg/kg/min titrated up 0.48 on day before extubation, allowing reduction other sedatives. She received total 16 hours (5.66 mg) it discontinued, successfully performed 70 minutes later. 2, three-year-old severe neck abscess intubation following surgical drainage. started 0.1 increased 0.2 facilitating tapering 23 (4.4 discontinuation, 25 Throughout administration, hemodynamic stability maintained, no occurrences hypotension, bradycardia, desaturation, hepatic or renal dysfunction, muscle rigidity, hyperalgesia. No additional catecholamines were required, signs withdrawal symptoms observed. These findings suggest that be safe effective option analgesia patients undergoing

Language: Английский