The unique properties of IgG4 and its roles in health and disease

Nature reviews. Immunology, Journal Year: 2023, Volume and Issue: 23(11), P. 763 - 778

Published: April 24, 2023

Language: Английский

---

Effects of physical processing on food protein allergenicity: A focus on differences between animal and alternative proteins

Food Chemistry, Journal Year: 2024, Volume and Issue: 460, P. 140559 - 140559

Published: July 20, 2024

Language: Английский

---

The clinical significance of allergen-specific IgG4 in allergic diseases

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Oct. 25, 2022

IgG4 is a subclass of IgG antibody with unique molecular feature (Fragment antigen- binding) Fab-arm exchange, allowing bi specific antigen binding in mono -valent manner. With low affinity to C1q and Fcγreceptors, incapable forming immune complexes activating the complement pathway, exhibiting non-inflammatory feature. produced similarly IgE considered modified reaction class-switching response under certain conditions. It could also counteract IgE-activated inflammation. However, clinical significance allergic diseases complex controversial. Three viewpoints have been suggested describe role IgG4. can act as tolerance–inducer play protective repeated rapid incremental dosing allergen exposure immunotherapy (AIT), supported by allergies cat raisers venom desensitization beekeepers. Another viewpoint accepted mainstream specialists guidelines Food Allergy Management different countries points out that food-specific bystander food allergy should not be used diagnostic tool work. eosinophilic esophagitis (EoE) investigation revealed direct relevance between physiopathology serum cow milk wheat. These factors indicate allergen-specific plays multifaceted or pathogenic depending on allergens

Language: Английский

---

Outcomes of Serum Food-Specific Immunoglobulin G4 to Guide Elimination Diet in Patients With Eosinophilic Esophagitis

The American Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: 119(6), P. 1066 - 1073

Published: Feb. 1, 2024

INTRODUCTION: Eosinophilic esophagitis (EoE) is associated with atopy; however, recent studies have identified an association food-specific immunoglobulin G 4 (FS-IgG ) rather than E antibodies. This study aimed to evaluate the role of serum FS-IgG in guiding elimination diet and its outcomes. METHODS: Patients without EoE were enrolled a prospective, controlled, single tertiary center trial. Serum titers, esophageal eosinophil counts, dysphagia symptom questionnaire scores assessed, participants elevated (ImmunoCAP, cutoff 10 mgA/L) commenced 6-week targeted diet. Repeat endoscopic histologic examination performed at follow-up. RESULTS: Twenty-two patients active 13 controls recruited. milk, wheat, soy, eggs, nuts was significantly higher ( P = 0.0002, 0.002, 0.003, 0.012, < 0.001, respectively). Elevated 1 or more food groups (median 2) 21/22 (95.4%) EoE; 20/21 underwent dietary elimination. Median reductions score reference after 8 0.0007) 0.002), respectively. Nine (45%) had histological remission (<15 eosinophils per high-power field). Fall median count not statistically significant (50 vs 23; 0.068). did decline by DISCUSSION: egg, present levels EoE, resulting 45% rate. has potential as noninvasive biomarker EoE. When successful, –led can negate need for medications be viewed favorably because smaller burden compared empirical diets.

Language: Английский

---

Update on In Vitro Diagnostic Tools and Treatments for Food Allergies

Nutrients, Journal Year: 2023, Volume and Issue: 15(17), P. 3744 - 3744

Published: Aug. 26, 2023

Food allergy (FA) is an adverse immunological reaction to a specific food that can trigger wide range of symptoms from mild life-threatening. This caused by different mechanisms, such as IgE-mediated, non-IgE-mediated and mixed IgE-mediated reactions. Its epidemiology has had significant increase in the last decade, more so developed countries. It estimated approximately 2 10% world’s population FA this number appears be increasing also affecting children. The diagnosis complex requires combination tests establish accurate diagnosis. However, treatment based on avoiding intake allergenic food, thus being very difficult at times controlling case accidental exposure. Currently, there are other immunomodulatory treatments allergen immunotherapy or innovative induce tolerance response. important mention research field ongoing clinical trials underway assess safety efficacy these approaches, new pathways used target promote In review, we describe vitro diagnostic tools therapeutic show latest advances management. We conclude although have been made improve therapies for FA, urgent need standardize both that, their totality, they help management FA.

Language: Английский

---

Immunoglobulin G4 in primary Sjögren’s syndrome and IgG4-related disease - connections and dissimilarities

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 19, 2024

Primary Sjögren’s syndrome (pSS) is an autoimmune disease, with B cell hyperactivation and autoantibody production as its immunological hallmarks. Although the distinction between immunoglobulin G4-related disease (IgG4-RD) pSS, based on presence or absence of certain autoantibodies, seems easy to make, possibility elevated serum IgG4 concentration often similar organ involvement may lead a misdiagnosis. The increased in IgG4-RD not clearly linked pathogenesis IgG-RD it has been suggested that constitute just epiphenomenon. aim this article discuss pSS potential significance for these two diseases.

Language: Английский

---

A conversation on allergy: recognizing the past and looking to the future

Immunology and Cell Biology, Journal Year: 2023, Volume and Issue: 101(10), P. 936 - 946

Published: Sept. 9, 2023

Abstract Allergy is an ever‐evolving group of disorders, which includes asthma, atopic dermatitis, rhinitis and food allergies that currently affects over 1 billion people worldwide. This disorders has exploded in incidence since around the start 20th century, implying genetics not solely responsible for its development but environmental factors have important role. Here, Fabio Luciani Jonathan Coquet, their role as editors at Immunology & Cell Biology , asked nine prominent researchers field allergy to define term ‘allergy’, discuss environment, nominate most discoveries past decade describe best strategies combat population level going forward.

Language: Английский

---

Can we alter the course of allergic disease?

Annals of Allergy Asthma & Immunology, Journal Year: 2022, Volume and Issue: 129(3), P. 271 - 273

Published: July 14, 2022

It becomes obvious from this outline that the increase in each form of allergic disease results very different causes. In no case were consequences relation to predicted, and it is difficult believe any these changes could have been stopped if we had known what was going happen. Basically, are watching inexorable progress modern civilization with all its intended unintended consequences. What would like emphasize basic hygiene, clean water, complete separation fecal matter food production, helminth eradication before most major rises disease. Thus, diseases discuss occurred "post-hygiene." There one change arguably has decreased severity 2 diseases, air conditioning closing houses so exchange rates as low 0.6 per hour. This means only minimal quantities pollen can enter but also become drier less hospitable mites. keeping apartments, both hay fever asthma severe since 2000. Needless say, effects never advertised a reason for change.

Language: Английский

---

Rapid diagnosis of egg allergy by targeting ovalbumin specific IgE and IgG4 in serum on a disposable electrochemical immunoplatform

Sensors & Diagnostics, Journal Year: 2021, Volume and Issue: 1(1), P. 149 - 159

Published: Dec. 10, 2021

First electrochemical bioplatforms described for the single and simultaneous determination of two immunoglobulin (Ig) subtypes, IgE IgG4 specific to ovalbumin (OVA), considered as reliable markers diagnosis monitoring egg allergy.

Language: Английский

---

Peanut-specific IgG subclasses as biomarkers of peanut allergy in LEAP study participants

World Allergy Organization Journal, Journal Year: 2024, Volume and Issue: 17(8), P. 100940 - 100940

Published: Aug. 1, 2024

Antigen-specific IgG2 and IgG3 are rarely measured in food allergy clinical trials despite known function preventing mast cell basophil activation. Our objective was to determine whether measuring peanut-specific levels would correlate with peanut status. Peanut-specific IgG subclasses were via ELISA assays Learning Early About Peanut (LEAP) trial participants at 5 years of age correlated vs sensitization non-peanut allergic consumption avoidance. IgG1, IgG2, IgG3, IgG4 significantly different between allergic, a multivariate logistic regression model stepwise selection found that IgG1 most closely associated Similarly, all differentiated those consuming avoiding peanut, but subsequent modeling Amongst the subclasses, best biomarker for allergy, while antigen exposure this highly atopic cohort. study did not find added value from evaluating 2 3 as biomarkers although they allergy. Subsequent studies should assess adding models predicting

Language: Английский

---