Sleep duration is associated with liver steatosis in children depending on body adiposity DOI Creative Commons
Begoña de Cuevillas, Judith Lubrecht, Santiago Navas‐Carretero

et al.

European Journal of Pediatrics, Journal Year: 2023, Volume and Issue: 183(2), P. 779 - 789

Published: Nov. 25, 2023

Sleep is a factor associated with overweight/obesity risk, wherein interactions fatty liver should be ascertained. The aim of this cross-sectional study was to analyze the possible relationships sleep health and whether interplay related body adiposity distribution in children adolescents. Anthropometric, clinical, biochemical measurements were performed adolescents (2-18 years old) (n = 854). Body fat clinically assessed, several hepatic markers, including steatosis index, calculated. time mediation (hours/day) relationship between index investigated. Differences among diverse disease scores found overweight or obesity (p < 0.05). Linear regression models showed associations lifestyle markers 0.001). Hepatic higher (about + 15%) compared Pear-shaped may seemingly play more detrimental role on deposition. association dependent mass z-score. Post hoc analyses that 39% explained by time. Conclusion: An observed overweight/obesity, which can relevant prevention treatment excessive 2 18 old.

Language: Английский

Risk factors of high inflammatory state in pediatric obstructive sleep apnea DOI
Yanyu He,

Xueyun Xu,

Meng Lv

et al.

Sleep And Breathing, Journal Year: 2025, Volume and Issue: 29(1)

Published: Feb. 28, 2025

Language: Английский

Citations

0
Linear Relationship between Hepatic Steatosis Index and Major Adverse Cardiovascular Events in Hypertensive Patients with Obstructive Sleep Apnea: A Real-World Cohort Study from China DOI Creative Commons
Wen Wen, Xintian Cai,

Qing Zhu

et al.

Reviews in Cardiovascular Medicine, Journal Year: 2023, Volume and Issue: 24(10), P. 280 - 280

Published: Oct. 7, 2023

Background: Hypertensive patients with obstructive sleep apnea (OSA) are at a high risk of cardiovascular disease (CVD), but assessments CVD in this population frequently constrained by the presence comorbid medical conditions. The noninvasive and convenient hepatic steatosis index (HSI) can not only predict degree fatty liver degeneration also correlates well severity numerous diseases. However, relationship between HSI hypertensive OSA remains unclear. Methods: This retrospective cohort study included aged ≥18 years hypertension primary diagnosis grouped them according to their baseline HSI. outcome was new or recurrent major adverse cerebrovascular events (MACCE), while secondary outcomes were cardiac events. endpoint evaluated using Kaplan–Meier curves, risk-factor graphs, Cox regression models, generalized additive models used identify linear relationships. C-statistic, integrated discrimination improvement (IDI), net reclassification (NRI) evaluate predictive value increments for Results: A total 2467 participants analysis separated into four groups (Q1–Q4) based on quartiles. survival curves indicated that Q4 group had lowest time. showed significantly higher MACCE (HR [hazard ratio], 2.95; 95% CI [confidence interva]: 1.99–4.39; p < 0.001), (HR, 2.80; CI: 1.68–4.66; 3.21; 1.71–6.03; 0.001). dose-response curve revealed association occurrence For every unit increase HSI, risks MACCE, events, increased 43%, 38%, 51%, respectively. IDI, NRI all model including better discriminatory classification efficacy comparison conventional (p 0.05). Conclusions: patients.

Language: Английский

Citations

9
Pediatric Sleep Questionnaire Predicts Moderate-to-Severe Obstructive Sleep Apnea in Children and Adolescents with Obesity DOI Creative Commons
Giuseppina Rosaria Umano, Giulia Rondinelli,

Margherita Luciano

et al.

Children, Journal Year: 2022, Volume and Issue: 9(9), P. 1303 - 1303

Published: Aug. 27, 2022

Pediatric obesity is associated with an increased risk of morbidity during childhood. Alongside the well-known metabolic syndrome, last decades scientific research has deeply investigated sleep breathing disorders. Among them, obstructive apnea (OSA) commonly affects children obesity. The presence OSA heightens impairment and weight gain. Therefore, it deserves specific treatment. However, polysomnography (PSG) not always available in clinical settings, alternative diagnostic tools are needed. This study aimed to investigate predictivity pediatric questionnaire (PSQ) for moderate-to-severe diagnosis. Children adolescents suspected full-night cardiorespiratory PSG were retrospectively enrolled. Receiver operating curve analysis was performed test ability PSQ predicting (AHI > 5 episode/h). final sample included 60 adolescents. showed a good area under (AUC) 0.88 (95% CI 0.78−0.98, p < 0.0001). Moreover, value above or equal 0.65 80% sensitivity 100% specificity moderate severe OSA. These findings suggest that might be used settings limited access stratifying disease severity selecting urgent need study.

Language: Английский

Citations

13
Obstructive sleep apnea (OSA) is associated with the impairment of beta-cell response to glucose in children and adolescents with obesity DOI Creative Commons
Giuseppina Rosaria Umano, Alfonso Galderisi, Francesca Aiello

et al.

International Journal of Obesity, Journal Year: 2023, Volume and Issue: 47(4), P. 257 - 262

Published: Jan. 20, 2023

The main purpose of the study is to assess association between obstructive sleep apnea (OSA) and insulin secretion in children with obesity.We enrolled adolescents who attended our pediatric clinic because obesity OSA. Glucose homeostasis was assessed through standard 2-h oral glucose tolerance test (OGTT). Nocturnal cardio-respiratory polygraphy performed for OSA diagnosis. Twenty-two patients underwent a 3-h OGTT investigate sensitivity oral-minimal model.seventy-seven were included study. Based on severity, cohort divided into three groups (29 mild, 29 moderate, 19 severe OSA). group mild showed lower levels 30-min (p = 0.01) 60-min 0.03), prevalence elevated 1-h (10.4% versus 44.8% moderate 31.6% OSA, p 0.01). odds plasma 6.2-fold (95%CI 1.6-23.4) higher subjects compared 0.007) independent confounders. Spearman correlation revealed positive apnea-hypopnea index (AHI, r 0.31, 0.01), oxygen desaturation (ODI, 0.009), mean (r 0.25, 0.04). 22 participants (7 9 6 dynamic, static, total those < 0.0001, 0.007, respectively). AHI significantly correlated dynamic -0.48, 0.02).OSA might impair beta-cell function reducing pool promptly releasable obesity, absence an effect sensitivity.

Language: Английский

Citations

4
Elastography as a non-invasive method of screening non-alcoholic fatty liver disease in the adult phenotype of paediatric obstructive sleep apnoea DOI Creative Commons
Anna Ďurdíková, Peter Ďurdík, Marek Pršo

et al.

Sleep And Breathing, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 12, 2024

Language: Английский

Citations

1
Current Concepts in Pediatric Obstructive Sleep Apnea DOI Creative Commons
Manisha Witmans, Mary Anne Tablizo

Children, Journal Year: 2023, Volume and Issue: 10(3), P. 480 - 480

Published: March 1, 2023

Obstructive sleep apnea (OSA) is described as intermittent partial or complete upper airway obstruction that can disrupt respiratory and ventilatory patterns during [...].

Language: Английский

Citations

3
Sleep duration is associated with liver steatosis in children depending on body adiposity DOI Creative Commons
Begoña de Cuevillas, Judith Lubrecht, Santiago Navas‐Carretero

et al.

European Journal of Pediatrics, Journal Year: 2023, Volume and Issue: 183(2), P. 779 - 789

Published: Nov. 25, 2023

Sleep is a factor associated with overweight/obesity risk, wherein interactions fatty liver should be ascertained. The aim of this cross-sectional study was to analyze the possible relationships sleep health and whether interplay related body adiposity distribution in children adolescents. Anthropometric, clinical, biochemical measurements were performed adolescents (2-18 years old) (n = 854). Body fat clinically assessed, several hepatic markers, including steatosis index, calculated. time mediation (hours/day) relationship between index investigated. Differences among diverse disease scores found overweight or obesity (p < 0.05). Linear regression models showed associations lifestyle markers 0.001). Hepatic higher (about + 15%) compared Pear-shaped may seemingly play more detrimental role on deposition. association dependent mass z-score. Post hoc analyses that 39% explained by time. Conclusion: An observed overweight/obesity, which can relevant prevention treatment excessive 2 18 old.

Language: Английский

Citations

1