Biomedicine & Pharmacotherapy,
Journal Year:
2022,
Volume and Issue:
158, P. 114160 - 114160
Published: Dec. 24, 2022
Nonalcoholic
steatohepatitis
(NASH)
is
among
the
most
common
liver
diseases
in
world.
Flavonoids
from
Scutellaria
amoena
(SAF)
are
used
treatment
of
hepatopathy
China.
However,
effect
and
mechanism
against
NASH
remain
unclear.
We
investigated
alleviating
SAF
on
via
regulating
mitochondrial
dysfunction
oxidative
stress.
The
effects
were
evaluated
using
vitro
vivo
methods.
L02
cells
induced
by
fat
emulsion
to
establish
an
adipocytes
model,
followed
with
for
24
h.
rat
models
established
administration
a
high-fat
diet
12
weeks
administered
six
weeks.
Changes
body
weight,
organ
indexes,
lipid
levels,
inflammatory
cytokines,
indicators,
fatty
acid
metabolism
investigated.
significantly
improved
injury,
infiltration
rats.
notably
regulated
interleukin-6,
tumor
necrotic
factor-alpha,
superoxide
dismutase
(SOD),
glutathione
(GSH),
malondialdehyde
(MDA),
kelch-like
ECH-associated
protein
1
(Keap1),
nuclear
factor-erythroid
factor
2-related
2
(Nrf2),
heme
oxygenase-1
(HO-1).
Additionally,
dysfunction,
increased
levels
GSH,
SOD,
ATP
synthase,
complex
I
II,
decreased
level
MDA
mitochondria.
expression
β-oxidation
genes,
including
peroxisome
proliferator-activated
receptor
-gamma
coactivator-1alpha
(PGC-1α),
carnitine
palmitoyltransferase-1
(CPT1)
A,
CPT1B,
medium-chain
acyl-CoA
dehydrogenase,
long-chain
very
PPARα.
can
alleviate
function
stress
Keap1/Nrf2/HO-1
axis.
Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(4), P. 818 - 818
Published: March 27, 2023
Clostridioides
difficile
infection
(CDI)
appears
to
be
associated
with
different
liver
diseases.
C.
secretes
membrane
vesicles
(MVs),
which
may
involved
in
the
development
of
nonalcoholic
fatty
disease
(NALFD)
and
drug-induced
injury
(DILI).
In
this
study,
we
investigated
presence
difficile-derived
MVs
patients
without
CDI,
analyzed
their
effects
on
pathways
related
NAFLD
DILI
HepG2
cells.
Fecal
extracellular
from
CDI
showed
an
increase
MVs.
that
were
internalized
by
Toxigenic
decreased
mitochondrial
potential
increased
intracellular
ROS
compared
non-toxigenic
addition,
toxigenic
upregulated
expression
genes
fission
(FIS1
DRP1),
antioxidant
status
(GPX1),
apoptosis
(CASP3),
glycolysis
(HK2,
PDK1,
LDHA
PKM2)
β-oxidation
(CPT1A),
as
well
anti-
pro-inflammatory
(IL-6
IL-10).
However,
did
not
produce
changes
these
genes,
except
for
CPT1A,
was
also
increased.
conclusion,
metabolic
produced
obtained
present
feces
are
common
pathophysiological
features
observed
spectrum
DILI.
Pharmacological Research,
Journal Year:
2024,
Volume and Issue:
206, P. 107294 - 107294
Published: July 9, 2024
Liver
fibrosis
is
a
determinant-stage
process
of
many
chronic
liver
diseases
and
affected
over
7.9
billion
populations
worldwide
with
increasing
demands
ideal
therapeutic
agents.
Discovery
active
molecules
anti-hepatic
efficacies
presents
the
most
attacking
filed.
Here,
we
revealed
that
hepatic
L-aspartate
levels
were
decreased
in
CCl
Redox Report,
Journal Year:
2024,
Volume and Issue:
29(1)
Published: Sept. 2, 2024
Objectives
Alcohol
and
its
metabolites,
such
as
acetaldehyde,
induced
hepatic
mitochondrial
dysfunction
play
a
pathological
role
in
the
development
of
alcohol-related
liver
disease
(ALD).
Biomedicine & Pharmacotherapy,
Journal Year:
2022,
Volume and Issue:
158, P. 114160 - 114160
Published: Dec. 24, 2022
Nonalcoholic
steatohepatitis
(NASH)
is
among
the
most
common
liver
diseases
in
world.
Flavonoids
from
Scutellaria
amoena
(SAF)
are
used
treatment
of
hepatopathy
China.
However,
effect
and
mechanism
against
NASH
remain
unclear.
We
investigated
alleviating
SAF
on
via
regulating
mitochondrial
dysfunction
oxidative
stress.
The
effects
were
evaluated
using
vitro
vivo
methods.
L02
cells
induced
by
fat
emulsion
to
establish
an
adipocytes
model,
followed
with
for
24
h.
rat
models
established
administration
a
high-fat
diet
12
weeks
administered
six
weeks.
Changes
body
weight,
organ
indexes,
lipid
levels,
inflammatory
cytokines,
indicators,
fatty
acid
metabolism
investigated.
significantly
improved
injury,
infiltration
rats.
notably
regulated
interleukin-6,
tumor
necrotic
factor-alpha,
superoxide
dismutase
(SOD),
glutathione
(GSH),
malondialdehyde
(MDA),
kelch-like
ECH-associated
protein
1
(Keap1),
nuclear
factor-erythroid
factor
2-related
2
(Nrf2),
heme
oxygenase-1
(HO-1).
Additionally,
dysfunction,
increased
levels
GSH,
SOD,
ATP
synthase,
complex
I
II,
decreased
level
MDA
mitochondria.
expression
β-oxidation
genes,
including
peroxisome
proliferator-activated
receptor
-gamma
coactivator-1alpha
(PGC-1α),
carnitine
palmitoyltransferase-1
(CPT1)
A,
CPT1B,
medium-chain
acyl-CoA
dehydrogenase,
long-chain
very
PPARα.
can
alleviate
function
stress
Keap1/Nrf2/HO-1
axis.
