Lymphocytes Change Their Phenotype and Function in Systemic Lupus Erythematosus and Lupus Nephritis DOI Open Access
Eleni Moysidou, Michalis Christodoulou, Γεώργιος Λιούλιος

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(20), P. 10905 - 10905

Published: Oct. 10, 2024

Systemic lupus erythematosus (SLE) is a complex autoimmune disease, characterized by considerable changes in peripheral lymphocyte structure and function, that plays critical role commencing reviving the inflammatory immune signaling pathways. In healthy individuals, B lymphocytes have major guiding directing defense mechanisms against pathogens. Certain phenotype, including alterations surface endosomal receptors, occur presence of SLE lead to dysregulation subpopulations. Functional are loss self-tolerance, intra- extrafollicular activation, increased cytokine autoantibody production. T seem supporting, rather than leading, disease pathogenesis. Substantial aberrations subsets evident, include reduction cytotoxic, regulatory, advanced differentiated subtypes, together with an increase activated autoreactive forms abnormalities follicular cells. Up-regulated subpopulations, such as central effector memory cells, produce pre-inflammatory cytokines, activate lymphocytes, stimulate cell This review explores pivotal roles pathogenesis Lupus Nephritis, emphasizing multifaceted interactions their phenotypic functional dysregulations.

Language: Английский

B-Cell Receptor Repertoire: Recent Advances in Autoimmune Diseases DOI

Qian Wang,

Delong Feng, Sujie Jia

et al.

Clinical Reviews in Allergy & Immunology, Journal Year: 2024, Volume and Issue: 66(1), P. 76 - 98

Published: March 9, 2024

Language: Английский

Citations

7
Peripheral Blood B-Cell Subsets Frequency and Distribution and the BSF-2(IL-6) to CSIF:TGIF(IL-10) Ratio as Severity-Associated Signatures in Primary Open-Angle Glaucoma: A Case-Controlled Study DOI Creative Commons
Entsar R. Mokhtar, Asmaa A. Elmadbouly, Omaima I. Abo-Elkheir

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(3), P. 485 - 485

Published: Feb. 21, 2024

Although primary open-angle glaucoma (POAG) is a major cause of blindness worldwide, patients’ immune response and its relation to the disease course have not been fully unraveled in terms analyses circulating B-cell subsets, as well association these subsets with severity POAG clinical features. Subjects Methods: Flow cytometry was used determine subset frequencies from 30 patients grouped by hierarchical cluster analysis or mean deviation (MD) visual field (VF) correlated pathological data, BSF-2(IL-6) CSIF:TGIF(IL-10), which were quantified peripheral blood samples controls ELISA. Results: The total frequency increased group comparison control (n = 30). Frequencies specific such double-negative (DN) naïve disease. However, unswitched memory B compartment decreased group. Other non-typical DN cells also showed significant changes according course. These differences allow us identify severity-associated inflammatory clusters specifically altered subsets. Finally, ocular parameters, biomarkers inflammation, other glaucoma-related non-clinical scores exhibited correlations some subpopulations. Conclusion: accompanied subpopulation, namely, cells. Furthermore, existing relationship parameters BSF-2(IL-6), CSIF:TGIF(IL-10) ratio suggests that lymphocyte could serve potential molecular bio-markers for assessing and/or progression.

Language: Английский

Citations

4
Changes of Peripheral T Cells in Systemic Lupus Erythematosus Patients DOI Creative Commons
Juanfeng Lao,

Rongjun Huang,

Rongcai Wu

et al.

Immunity Inflammation and Disease, Journal Year: 2025, Volume and Issue: 13(2)

Published: Feb. 1, 2025

ABSTRACT Background Efficient indicators for evaluating the imbalance of lymphocyte function were crucial to clinical therapy in systemic lupus erythematosus (SLE) patients. This study aimed find biomarkers assess lymphocyte‐mediated immune response SLE Methods A total 81 patients (non‐active: n = 35, active: 46) and 70 healthy donors recruited study. Peripheral blood was obtained, flow cytometry used detect circulating lymphocytes. Results Data showed that counts CD3 + T, CD4 CD8 NK cells decreased active compared with non‐active donors. The peripheral T increased responders but non‐responders among In addition, an increase B cell found those other two groups. Active higher percentages memory lower naive than controls. Activation molecules (CD38 HLA‐DR) inhibitory molecule PD‐1 expressions on significantly CD28 Conclusion indicated monitoring alterations surface may be helpful disease activity patients, even discriminate which beneficial choose best treatment option therapy.

Language: Английский

Citations

0
The role of double-negative B cells in the pathogenesis of systemic lupus erythematosus DOI
Xinying Qiu, Ran Wen, Feifeng Wu

et al.

Autoimmunity Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 103821 - 103821

Published: April 1, 2025

Language: Английский

Citations

0
Lymphocytes Change Their Phenotype and Function in Systemic Lupus Erythematosus and Lupus Nephritis DOI Open Access
Eleni Moysidou, Michalis Christodoulou, Γεώργιος Λιούλιος

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(20), P. 10905 - 10905

Published: Oct. 10, 2024

Systemic lupus erythematosus (SLE) is a complex autoimmune disease, characterized by considerable changes in peripheral lymphocyte structure and function, that plays critical role commencing reviving the inflammatory immune signaling pathways. In healthy individuals, B lymphocytes have major guiding directing defense mechanisms against pathogens. Certain phenotype, including alterations surface endosomal receptors, occur presence of SLE lead to dysregulation subpopulations. Functional are loss self-tolerance, intra- extrafollicular activation, increased cytokine autoantibody production. T seem supporting, rather than leading, disease pathogenesis. Substantial aberrations subsets evident, include reduction cytotoxic, regulatory, advanced differentiated subtypes, together with an increase activated autoreactive forms abnormalities follicular cells. Up-regulated subpopulations, such as central effector memory cells, produce pre-inflammatory cytokines, activate lymphocytes, stimulate cell This review explores pivotal roles pathogenesis Lupus Nephritis, emphasizing multifaceted interactions their phenotypic functional dysregulations.

Language: Английский

Citations

3