The Effect of Virgin Coconut and Black Cumin Oils on TNF-alpha Expression and Histopathological in Diabetic Rat Wound Healing DOI

Eliza Arman,

A Almahdy,

Putri Dafriani

et al.

Research Journal of Pharmacy and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 6076 - 6083

Published: Dec. 27, 2024

Background: Wound healing is a multifaceted process requiring the collaboration of various elements to facilitate repair damaged tissue. To accelerate process, Virgin Coconut Oil (VCO) and black cumin oil are plant oils that have been proven offer several beneficial pharmacological effects. Therefore, this study aimed determine effect VCO oil, as well their combination, on expression TNF-α histopathological features during wound in diabetic rat. Methods: Rat were injected with streptozotocin (55 mg/kg BW) 10 mm was created (n=30). Subsequently, rat randomly divided into six groups (n=5), consisting control (Untreated), VCO, C1, C2, C3 groups. Topical application performed once daily for 14 days. between evaluated using visual observation, hematoxylin eosin staining. Meanwhile, gene analyzed RT-PCR days 7 14, followed by data analysis one-way ANOVA. Results: The C1 group receiving topical combination showed moderate closure pattern characterized good shape, thickest epidermis, higher granulation, greater collagen density, fibroblast, lower inflammatory cell infiltration compared others. C2 significantly decreased day 7. In contrast, reduced group. Regarding features, provided optimal others.Conclusion: accelerated inducing decrease providing an intermediate pattern.

Language: Английский

β-Cyclodextrin/PVP-Stabilized Nanocrystal Gel for Dual Release of Rutin and Thymoquinone for Wound Healing DOI
Tahani M. Almeleebia,

Nandini Goyal,

Md Habban Akhter

et al.

Journal of Cluster Science, Journal Year: 2024, Volume and Issue: 36(1)

Published: Dec. 3, 2024

Language: Английский

Citations

0
The Effect of Virgin Coconut and Black Cumin Oils on TNF-alpha Expression and Histopathological in Diabetic Rat Wound Healing DOI

Eliza Arman,

A Almahdy,

Putri Dafriani

et al.

Research Journal of Pharmacy and Technology, Journal Year: 2024, Volume and Issue: unknown, P. 6076 - 6083

Published: Dec. 27, 2024

Background: Wound healing is a multifaceted process requiring the collaboration of various elements to facilitate repair damaged tissue. To accelerate process, Virgin Coconut Oil (VCO) and black cumin oil are plant oils that have been proven offer several beneficial pharmacological effects. Therefore, this study aimed determine effect VCO oil, as well their combination, on expression TNF-α histopathological features during wound in diabetic rat. Methods: Rat were injected with streptozotocin (55 mg/kg BW) 10 mm was created (n=30). Subsequently, rat randomly divided into six groups (n=5), consisting control (Untreated), VCO, C1, C2, C3 groups. Topical application performed once daily for 14 days. between evaluated using visual observation, hematoxylin eosin staining. Meanwhile, gene analyzed RT-PCR days 7 14, followed by data analysis one-way ANOVA. Results: The C1 group receiving topical combination showed moderate closure pattern characterized good shape, thickest epidermis, higher granulation, greater collagen density, fibroblast, lower inflammatory cell infiltration compared others. C2 significantly decreased day 7. In contrast, reduced group. Regarding features, provided optimal others.Conclusion: accelerated inducing decrease providing an intermediate pattern.

Language: Английский

Citations

0