The clinician's view on the advantages and contradictions of the new nomenclature of steatotic liver disease: A review DOI Creative Commons
Chavdar S Pavlov, Daria Teplyuk, Л. Б. Лазебник

et al.

Terapevticheskii arkhiv, Journal Year: 2024, Volume and Issue: 96(4), P. 429 - 435

Published: May 2, 2024

In September 2023, the European Association for Study of Liver (EASL) updated disease nomenclature non-alcoholic (metabolically associated) fatty liver disease. The goals revision were to increase awareness among health care professionals, civil society and patients about disease, its course, treatment outcomes; combating stigma; focusing on initial etiological factor, including main (cardiometabolic) risk progression; improved diagnosis based biomarkers; positive impact potency search new drugs; ability provide personalized medical care. terms “non-alcoholic” “fatty” considered stigmatizing, therefore, it was proposed use term steatotic (SLD) as name this nosology. (NAFLD) or metabolic associated (MAFLD) have been replaced by dysfunction-associated (MASLD). case being combined with an alcohol a in which dysfunction is alcoholic referred MetALD. fundamental principle MASLD presence at least one cardiometabolic factors. Alcohol consumption interacts factors increases SLD decompensation. nonalcoholic steatohepatitis (NASH), according nomenclature, has (MASH). adoption should help course outcomes, well improve quality treatment.

Language: Английский

Multi‐Organ Microphysiological Systems Targeting Specific Organs for Recapitulating Disease Phenotypes via Organ Crosstalk DOI Creative Commons

Joeng Ju Kim,

Mihyeon Bae, Dong‐Woo Cho

et al.

Small Science, Journal Year: 2024, Volume and Issue: 4(11)

Published: Sept. 19, 2024

Various systemic metabolic diseases arise from prolonged crosstalk across multiple organs, triggering serious impairments in various physiological systems. These are intricate pathologies characterized by complex mechanisms and an unclear etiology, making the treatment challenging. Efforts have been made to develop vitro models understand these devise new treatments. However, there limitations reconstructing causal relationships between interorgan crosstalk, including tissue-specific microenvironment. Alternatively, multi-organ microphysiological systems (MOMPS) present possibilities for capturing complexity of replicating human microphysiology simulating diverse crosstalk. Controlled interactions scalable representations biological MOMPS offer a more accurate portrayal organ interactions, enabling identification novel metabolism, immunity. This, turn, can yield valuable insights into disease drug development research enhance efficiency preclinical studies. In this review, examples technical capabilities pathological modeling discussed, leveraging state-of-the-art biofabrication technology MOMPS. It evaluates current opportunities challenges field.

Language: Английский

Citations

1
Impact of Diabetes Mellitus and Obesity Comorbidities on Survival Outcomes after Hepatocellular Carcinoma Resection: A Multicenter Retrospective Study DOI Creative Commons
Hiroji Shinkawa,

Masaki Kaibori,

Masaki Ueno

et al.

Liver Cancer, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 12

Published: Aug. 20, 2024

Introduction: This study aimed to evaluate the association of obesity and diabetes mellitus (DM) comorbidity with hepatocellular carcinoma (HCC) recurrence survival. Methods: We investigated 1,644 patients who underwent hepatic resection for solitary HCC without vascular invasion using computed tomography. Patients were categorized into four groups according combination DM comorbidities: OB (+) or (−) (−). Postoperative cumulative rates within beyond 2 years 5 assessed. Results: Multivariate Cox proportional hazard regression analysis revealed that adjusted ratios (HRs) reduced recurrence-free survival was 1.10 (95% confidence interval [CI]: 0.91–1.33; p = 0.31), 0.94 CI: 0.78–1.12; 0.48), 1.24 1.01–1.54; 0.045) in OB(+)DM(−), OB(−)DM(+), OB(+)DM(+) compared OB(−)DM(−) group, respectively. Additionally, corresponding HRs overall 0.93 (p 0.57), 0.97 0.76), 1.38 0.013) groups, No significant difference early rate determined among groups. The group demonstrated an increased risk late postoperatively (HR: 1.51; 0.024 HR: 2.53; 0.046, respectively). OB(+)DM(−) OB(−)DM(+) 3.83; < 0.001 1.95; 0.037, Conclusions: Obesity coexistence worsened prognosis undergoing resection. results help surgeons develop possible different surveillance protocol need focus on diabetes/obesity control during life-long HCC.

Language: Английский

Citations

1
Temporal changes in lipid concentrations and the prevalence of dyslipidemia among individuals with diabetes, prediabetes, and normal blood glucose from 2011 to 2015 DOI Creative Commons
Mengjie Zhao,

Yurong Cheng,

Mengxuan Li

et al.

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: Nov. 28, 2024

Dyslipidemia plays a pivotal role in the development of diabetes mellitus (DM) and other metabolic disorders. This study aimed to investigate trends lipid concentrations among Chinese participants with different blood glucose statuses—ranging from DM prediabetes (pre-DM) normal levels—between 2011 2015. Additionally, this sought provide comprehensive description potential temporal changes prevalence dyslipidemia these populations China during period. The data for were derived Health Retirement Longitudinal Study (CHARLS), encompassing two time points sample included 11,408 aged 45 years above, whereas 2015 12,224 within same age range. In study, comparative analysis revealed that individuals diagnosed pre-DM experienced significant decreases total cholesterol (TC) low-density lipoprotein (LDL-C) increase high-density (HDL-C) (P < 0.05). For pre-DM, levels residual (RC) significantly increased, atherogenic index plasma (AIP) decreased Among glucose, there was decrease TC LDL-C triglycerides (TGs), RCs, AIP Between 2015, TC, TG, LDL-C, RC, AIP, both unadjusted adjusted, higher than those opposite being true HDL-C. DM, 36.56% (95% CI: 34.49%, 38.66%), 15.78% 14.93%, 16.67%), 11.23% 10.17%, 12.36%), respectively. results present incidence urban areas between is greater patients, particularly 55–64 group. Notably, over four-year observation period, profiles improved patients patients. However, TG remained elevated, especially 45–54

Language: Английский

Citations

1
Palmitic acid induces insulin resistance and oxidative stress-mediated cell injury through accumulation of lipid rafts in murine hepatocytes DOI
Akira Uchiyama, Kazuyoshi Kon,

Maki Morinaga

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 745, P. 151242 - 151242

Published: Dec. 24, 2024

Language: Английский

Citations

1
The clinician's view on the advantages and contradictions of the new nomenclature of steatotic liver disease: A review DOI Creative Commons
Chavdar S Pavlov, Daria Teplyuk, Л. Б. Лазебник

et al.

Terapevticheskii arkhiv, Journal Year: 2024, Volume and Issue: 96(4), P. 429 - 435

Published: May 2, 2024

In September 2023, the European Association for Study of Liver (EASL) updated disease nomenclature non-alcoholic (metabolically associated) fatty liver disease. The goals revision were to increase awareness among health care professionals, civil society and patients about disease, its course, treatment outcomes; combating stigma; focusing on initial etiological factor, including main (cardiometabolic) risk progression; improved diagnosis based biomarkers; positive impact potency search new drugs; ability provide personalized medical care. terms “non-alcoholic” “fatty” considered stigmatizing, therefore, it was proposed use term steatotic (SLD) as name this nosology. (NAFLD) or metabolic associated (MAFLD) have been replaced by dysfunction-associated (MASLD). case being combined with an alcohol a in which dysfunction is alcoholic referred MetALD. fundamental principle MASLD presence at least one cardiometabolic factors. Alcohol consumption interacts factors increases SLD decompensation. nonalcoholic steatohepatitis (NASH), according nomenclature, has (MASH). adoption should help course outcomes, well improve quality treatment.

Language: Английский

Citations

0