Experimental Validation of Antiobesogenic and Osteoprotective Efficacy of Ginsenoside CK via Targeting Lipid and Atherosclerosis Pathways DOI Creative Commons
Md. Niaj Morshed, Reshmi Akter, Imran Mahmud

et al.

Life, Journal Year: 2024, Volume and Issue: 15(1), P. 41 - 41

Published: Dec. 31, 2024

The present study explored the possible antiobesogenic and osteoprotective properties of gut metabolite ginsenoside CK to clarify its influence on lipid atherosclerosis pathways, thereby validating previously published hypotheses. These hypotheses were validated by harvesting cultivating 3T3-L1 MC3T3-E1 in adipogenic osteogenic media with varying concentrations CK. We assessed differentiation adipocytes osteoblasts these cell lines applying most effective doses that we initially selected. Using vitro assessments, could effectively decrease intracellular accumulation, inhibit α-glucosidase enzyme, increase 2-NBDG glucose uptake, reduce inflammation-associated cytokines (TNFα, IL-6), regulatory genes (PPARγ, FAS, C/EBPα), lipogenic gene LPL, expression thermogenic UCP1. Additionally, treatment induced osteoblast development cells as shown increased mineralization calcium distribution, collagen content, alkaline phosphatase activity, decreased inflammatory TNFα, IL-6 regulated expressions including Runx2, ALP, BGLAP, OCN, Col1a1. Significantly, a major inhibitory regulator, TP53 was down-regulated both MC3T3E1 after encouraging results demonstrate use an innovative for controlling obesity osteoporosis, targeting underlying mechanisms obesogenic bone loss. Further studies are necessary explore clinical implications potential future strategies. This research highlights promise addressing significant health issues.

Language: Английский

Research progress on anti-aging effects and mechanisms of the new ginsenoside Compound K DOI Creative Commons

Zhiqin Fang,

Jingyin Zhang,

Jianwen Huang

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: 2(1), P. 100072 - 100072

Published: Jan. 31, 2025

Language: Английский

Citations

0
Potassium and Magnesium in American Ginseng Roots as Key Factors in Monitoring Soil Quality, Yield, and Quality: Screening, Prediction, and Validation DOI Creative Commons

Jiaqi Qian,

Hai Sun,

Cai Shao

et al.

Horticulturae, Journal Year: 2024, Volume and Issue: 10(4), P. 344 - 344

Published: March 29, 2024

Understanding the key roles of nutrient elements in soil–plant systems are essential for herbal medicine production and sustainable development. However, ecological relationships between soil quality elements, yield, saponins, or other active compounds American ginseng remain unclear. In this study, 20 indicators, 10 root 9 yields were investigated. The minimum dataset was constructed by principal component analysis, factors screened correlation analysis PLS-PM prediction model using linear fitting tested a validation test. dataset, based on comprised five indicators: SOM, TP, AK, AMg, ACa. Correlation showed that K Mg relating to yield when AMg 0.21 g/kg AK 0.30 g/kg, organic matter 27%, total phosphorus 1.19 soil, content roots 15.63 1.91 K/Mg 8.85 could balance quality. predicting validating model, DW, ginsenoside, Rb1, Rb2, Rc, Rd reliable. This study provides scientific basis regulation, selecting planting sites, assessing quality, evaluating

Language: Английский

Citations

2
Ginsenoside compound K alleviates d-galactose-induced mild cognitive impairment by modulating gut microbiota-mediated short-chain fatty acid metabolism DOI
Xiaojun Yan, Xue Bai, Rongzhan Fu

et al.

Food & Function, Journal Year: 2024, Volume and Issue: 15(18), P. 9037 - 9052

Published: Jan. 1, 2024

The occurrence and progression of mild cognitive impairment (MCI) are closely related to dysbiosis the gut microbiota. Ginsenoside compound K (CK), a bioactive component ginseng, has been shown alleviate microbiota neural damage. However, mechanisms by which CK regulates improve MCI remain unexplored. In this study, an mouse model induced D-galactose was used, 16S rRNA gene sequencing, metabolomics, transcriptomics, integrative multi-omics analyses were employed investigate potential alleviates through modulation results demonstrated that repaired intestinal barrier dysfunction caused MCI, improved blood-brain (BBB) integrity, inhibited activation microglial cells astrocytes, significantly ameliorated MCI. Furthermore, enhanced diversity, notably enriched beneficial bacteria such as

Language: Английский

Citations

2
Experimental Validation of Antiobesogenic and Osteoprotective Efficacy of Ginsenoside CK via Targeting Lipid and Atherosclerosis Pathways DOI Creative Commons
Md. Niaj Morshed, Reshmi Akter, Imran Mahmud

et al.

Life, Journal Year: 2024, Volume and Issue: 15(1), P. 41 - 41

Published: Dec. 31, 2024

The present study explored the possible antiobesogenic and osteoprotective properties of gut metabolite ginsenoside CK to clarify its influence on lipid atherosclerosis pathways, thereby validating previously published hypotheses. These hypotheses were validated by harvesting cultivating 3T3-L1 MC3T3-E1 in adipogenic osteogenic media with varying concentrations CK. We assessed differentiation adipocytes osteoblasts these cell lines applying most effective doses that we initially selected. Using vitro assessments, could effectively decrease intracellular accumulation, inhibit α-glucosidase enzyme, increase 2-NBDG glucose uptake, reduce inflammation-associated cytokines (TNFα, IL-6), regulatory genes (PPARγ, FAS, C/EBPα), lipogenic gene LPL, expression thermogenic UCP1. Additionally, treatment induced osteoblast development cells as shown increased mineralization calcium distribution, collagen content, alkaline phosphatase activity, decreased inflammatory TNFα, IL-6 regulated expressions including Runx2, ALP, BGLAP, OCN, Col1a1. Significantly, a major inhibitory regulator, TP53 was down-regulated both MC3T3E1 after encouraging results demonstrate use an innovative for controlling obesity osteoporosis, targeting underlying mechanisms obesogenic bone loss. Further studies are necessary explore clinical implications potential future strategies. This research highlights promise addressing significant health issues.

Language: Английский

Citations

0