Bibliometric analysis of autophagy in NAFLD from 2004 to 2023 DOI Creative Commons
Sumei Xu, Yating Zhang, Qi Huang

et al.

Medicine, Journal Year: 2024, Volume and Issue: 103(49), P. e40835 - e40835

Published: Dec. 6, 2024

Background: Autophagy is a cellular process in which damaged organelles or unnecessary proteins are encapsulated into double-membrane structures and transported to lysosomes for degradation. plays crucial role various liver diseases, including nonalcoholic fatty disease. This study aims elucidate the of autophagy disease through bibliometric analysis. Methods: Literature was retrieved from Web Science CoreCollection database, search time January 01, 2004 December 31, 2023. Data retrieval performed using Bibliometrix package R software. VOSviewer CiteSpace were utilized visualize research hotspots trends related effect on Results: A total 966 papers obtained, published 343 journals 1385 institutions across 57 countries. The with most publications “International Journal Molecular Sciences” “Scientific Reports.” China had highest number papers. productive authors Yen Paul M Jung Tae Woo, while Singh frequently co-cited author. Emerging associated keywords such as insulin resistance, ferroptosis, endoplasmic reticulum stress, mitochondrial function. Conclusion: Research still its early stages, growing body literature. first provide comprehensive analysis, synthesizing advancements. It identifies current development trends, global cooperation models, foundational knowledge, hotspots, emerging frontiers field.

Language: Английский

Spring viraemia of carp virus modulates the time-dependent unfolded protein response to facilitate viral replication DOI Creative Commons
Alex Romero, António Figueras, Beatriz Novoa

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 3, 2025

The spring viraemia of carp virus (SVCV) poses a significant threat to global aquaculture, yet effective antiviral drugs and vaccines remain unavailable. Understanding the interplay between host-pathogen interactions SVCV replication is crucial for devising preventive strategies. ZF4 cells were exposed UV-inactivated or live at different multiplicities infection, modulation unfolded protein response (UPR) was assayed by qPCR times. Moreover, treated with several UPR modulators investigate their effect on viral replication. also modulated in vivo zebrafish larvae, its impact survival against infection evaluated. This study reveals how exploits host's facilitate targets immunoglobulin heavy chain-binding (BiP) activating transcription factor 4 (ATF4) during early enhance RNA synthesis translation. At later stages, activation BiP, PKR-like ER kinase (PERK), inositol-requiring enzyme 1 alpha (IRE1α) pathways supports release progeny induces cellular processes, including immune responses apoptotic cell death. Furthermore, data demonstrate that modulating pathways, particularly ATF6 PERK, significantly affect replication, providing novel avenue drug development. Preliminary studies suggest feasibility chemically combat SVCV, though optimizing administration conditions maximize efficacy while minimizing side effects warrants further investigation. These findings offer critical insights into molecular mechanisms underlying pathogenesis highlight promising therapeutic intervention.

Language: Английский

Citations

0
Acute COVID-19 and LongCOVID syndrome – molecular implications for therapeutic strategies - review DOI Creative Commons
Katarzyna Michalak,

Alicja Michalak,

Alicja Brenk-Krakowska

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 17, 2025

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has been recognized not only for its acute effects but also ability to cause LongCOVID (LCS), a condition characterized by persistent symptoms affecting multiple organ systems. This review examines the molecular and immunological mechanisms underlying LCS, with particular focus on autophagy inhibition, chronic inflammation, oxidative, nitrosative calcium stress, viral persistence autoimmunology. Potential pathophysiological involved in LCS include (1) autoimmune activation, (2) latent persistence, where SARS-CoV-2 continues influence host metabolism, (3) reactivation of pathogens such as Epstein-Barr virus (EBV) or cytomegalovirus (CMV), exacerbating immune metabolic dysregulation, (4) possible inflammatory body fails restore post-infection homeostasis. The manipulation cellular pathways proteins is critical aspect virus’ evade clearance establish long-term dysfunction. Viral NSP13, ORF3a ORF8 have shown disrupt autophagy, thereby impairing promoting evasion. In addition, mitochondrial dysfunction, dysregulated signaling, oxidative HIF-1α activation Nrf2 inhibition create self-sustaining feedback loop that contributes tissue damage symptoms. Therefore understanding basis development effective therapeutic strategies. Targeting glycolysis restoration homeostasis may provide novel strategies mitigate consequences infection. Future research should personalized interventions based dominant perturbations individual patients.

Language: Английский

Citations

0
Severe disease is not essential for a high neutralizing antibody response post-SARS-CoV-2 infection DOI Creative Commons
Afrah Khairallah,

Zesuliwe Jule,

Alice Piller

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 21, 2024

Neutralizing antibody responses correlate with protection from SARS-CoV-2 infection, yet higher neutralizing associate more severe disease. Whether people without disease can also develop strong to and the pathways involved, is less clear. We performed a proteomic analysis on sera 71 individuals infected ancestral SARS-CoV-2, enrolled during first South African infection wave. determined severity by whether participants required supplemental oxygen measured levels at convalescence. High antibodies were associated high severity, 40% of lower had comparable those found 130 differentially expressed proteins between low neutralizers 40 versus severity. Five overlapped, including furin, protease which enhances infection. non-severe similar neutralization response disease, Furthermore, we could reasonably predict who developed based single protein, HSPA8, involved in clathrin pit uncoating. These results indicate that does not always require may involve different pathways.

Language: Английский

Citations

0
Bibliometric analysis of autophagy in NAFLD from 2004 to 2023 DOI Creative Commons
Sumei Xu, Yating Zhang, Qi Huang

et al.

Medicine, Journal Year: 2024, Volume and Issue: 103(49), P. e40835 - e40835

Published: Dec. 6, 2024

Background: Autophagy is a cellular process in which damaged organelles or unnecessary proteins are encapsulated into double-membrane structures and transported to lysosomes for degradation. plays crucial role various liver diseases, including nonalcoholic fatty disease. This study aims elucidate the of autophagy disease through bibliometric analysis. Methods: Literature was retrieved from Web Science CoreCollection database, search time January 01, 2004 December 31, 2023. Data retrieval performed using Bibliometrix package R software. VOSviewer CiteSpace were utilized visualize research hotspots trends related effect on Results: A total 966 papers obtained, published 343 journals 1385 institutions across 57 countries. The with most publications “International Journal Molecular Sciences” “Scientific Reports.” China had highest number papers. productive authors Yen Paul M Jung Tae Woo, while Singh frequently co-cited author. Emerging associated keywords such as insulin resistance, ferroptosis, endoplasmic reticulum stress, mitochondrial function. Conclusion: Research still its early stages, growing body literature. first provide comprehensive analysis, synthesizing advancements. It identifies current development trends, global cooperation models, foundational knowledge, hotspots, emerging frontiers field.

Language: Английский

Citations

0