Fracture Risk in People With Haemophilia A and B: A Systematic Review and Meta‐Analysis
Haemophilia,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 18, 2025
ABSTRACT
Introduction
Haemophilia
A
and
B
is
a
disease
consistently
associated
with
reduced
bone
mineral
density,
both
in
adults
children.
However,
whether
haemophilia
also
increases
fracture
risk
has
not
yet
been
proven.
Aim
This
systematic
review
meta‐analysis
aimed
to
synthesize
analyse
studies
evaluating
the
association
between
risk.
Methods
Comprehensive
research
was
conducted
three
electronic
databases
(PubMed,
CENTRAL,
Scopus)
up
30
June
2024.
Data
were
expressed
as
relative
(RR)
95%
confidence
intervals
(CI).
The
I
2
index
employed
evaluate
heterogeneity.
Results
Fourteen
included
qualitative
four
quantitative
analysis
(participants:
13,221,
publication
years:
2007–2022).
Regarding
design,
five
retrospective
cohorts,
two
case‐control,
seven
cross‐sectional.
Fracture
prevalence
people
(PWH)
5.7%,
ranging
from
1.4%
27.7%
(data
14
studies),
compared
0.9%
control
group,
0%
5.1%
3
studies).
In
comparison
healthy
men,
PWH
demonstrated
increased
(RR
4.56,
CI
1.28–16.25,
p
=
0.019,
90.74%).
there
insufficient
data
categorize
fractures
according
their
location
compare
incidence
patients
receiving
prophylaxis
those
on‐demand
treatment,
well
type
or
severity
of
haemophilia.
Conclusion
first
showing
more
than
4‐fold
general
population.
Language: Английский
Introduction to Special Issue: Genomic Analysis of Common Disease
Current Issues in Molecular Biology,
Journal Year:
2025,
Volume and Issue:
47(2), P. 112 - 112
Published: Feb. 10, 2025
The
development
of
NextGen
or
massive
parallel
sequencing
[...].
Language: Английский
Transforming Hemophilia A Care: Insights into New Therapeutic Options
Life,
Journal Year:
2024,
Volume and Issue:
14(12), P. 1568 - 1568
Published: Nov. 29, 2024
Hemophilia
A
is
a
hereditary
bleeding
disorder
characterized
by
deficiency
in
clotting
factor
VIII,
leading
to
significant
morbidity
and
reduced
quality
of
life.
This
review
provides
an
updated
overview
the
current
understanding
hemophilia
A,
highlighting
its
genetic
underpinnings
advancements
treatment
strategies.
literature
was
conducted
using
various
available
databases.
Relevant
studies
on
covering
genetics
options,
were
selected
summarized.
Recent
developments
gene
therapy
are
discussed,
showcasing
their
potential
offer
long-term
solutions
reduce
burden
treatment.
Additionally,
addresses
global
disparities
care
policy
implications,
emphasizing
need
for
comprehensive
healthcare
frameworks
improve
outcomes
individuals
living
with
worldwide.
By
synthesizing
recent
findings
insights,
this
aims
inform
clinicians
policymakers
about
evolving
landscape
management
necessity
equitable
access
care.
Language: Английский