LINE-1 cfDNA Methylation as an Emerging Biomarker in Solid Cancers DOI Open Access
Uğur Gezer, Emre Özgür, Ebru Esin Yörüker

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(22), P. 3725 - 3725

Published: Nov. 5, 2024

Epigenetic dysregulation is a hallmark of many human malignancies, with DNA methylation being primary mechanism influencing gene expression and maintaining genomic stability. Genome-wide hypomethylation, characteristic cancers, partly attributed to the demethylation repetitive elements, including LINE-1, prevalent non-LTR retrotransposon. The status LINE-1 closely associated overall levels in tumors. cfDNA comprises extracellular fragments found bodily fluids such as plasma, serum, urine, offering dynamic snapshot genetic epigenetic landscape This real-time sampling provides minimally invasive avenue for cancer diagnostics, prognostics, monitoring. has emerged promising biomarker, several studies highlighting its potential diagnosing predicting outcomes patients. Recent research also suggests that cfDNA-based analysis could serve valuable tool evaluating efficacy therapies, immunotherapy. growing clinical significance calls closer examination components, particularly elements like LINE-1. Despite their importance, role not been thoroughly gauged. We aim address this gap by reviewing current literature on assays, focusing applications diagnostics disease

Language: Английский

Introduction to Special Issue: Genomic Analysis of Common Disease DOI Creative Commons
Golder N. Wilson

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(2), P. 112 - 112

Published: Feb. 10, 2025

The development of NextGen or massive parallel sequencing [...].

Language: Английский

Citations

0
Cell-free DNA: plays an essential role in early diagnosis and immunotherapy of pancreatic cancer DOI Creative Commons
Yi Wen, Grace Zhao, Chunhua Dai

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 7, 2025

Pancreatic cancer is renowned for its aggressive nature and dismal prognosis, with the majority of patients diagnosed at an advanced stage. The prognosis pancreatic can be improved by early diagnosis effective treatment. Circulating cell-free DNA (cfDNA) has emerged as a promising biomarker monitoring cancer. This research presents review circulating essential role in immunotherapy detection methods cfDNA, potential diagnostic biomarker, latest progress cfDNA-based are discussed. findings suggest that cfDNA plays vital personalised treatment cancer, holding great promise improving patient outcomes.

Language: Английский

Citations

0
DNA Methylation in Ph-Negative Myeloproliferative Neoplasms: Prognostic Role and Therapeutic Implications DOI Creative Commons

Paola Barone,

Adele Bottaro,

Rossana Leanza

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(4), P. 227 - 227

Published: March 26, 2025

Myeloproliferative neoplasms are clonal hematological characterized by excessive proliferation of cells erythroid, granulocytic, and megakaryocytic lineage. The genetic mechanisms underlying this group blood diseases now known, but new perspectives have recently emerged in the field epigenetics particularly related to possible role DNA methylation disease development progression. regulates different cellular processes, such as proliferation, differentiation, apoptosis. In myeloproliferative neoplasms, a link has been found between abnormal patterns, hypermethylation tumor suppressors or, conversely, oncogenes hypomethylation, with progression disease, spreading important prognostic therapeutic implications. This review aims investigate relationship alterations emphasizing ways which epigenetic dysregulation promotes biology.

Language: Английский

Citations

0
LINE-1 cfDNA Methylation as an Emerging Biomarker in Solid Cancers DOI Open Access
Uğur Gezer, Emre Özgür, Ebru Esin Yörüker

et al.

Cancers, Journal Year: 2024, Volume and Issue: 16(22), P. 3725 - 3725

Published: Nov. 5, 2024

Epigenetic dysregulation is a hallmark of many human malignancies, with DNA methylation being primary mechanism influencing gene expression and maintaining genomic stability. Genome-wide hypomethylation, characteristic cancers, partly attributed to the demethylation repetitive elements, including LINE-1, prevalent non-LTR retrotransposon. The status LINE-1 closely associated overall levels in tumors. cfDNA comprises extracellular fragments found bodily fluids such as plasma, serum, urine, offering dynamic snapshot genetic epigenetic landscape This real-time sampling provides minimally invasive avenue for cancer diagnostics, prognostics, monitoring. has emerged promising biomarker, several studies highlighting its potential diagnosing predicting outcomes patients. Recent research also suggests that cfDNA-based analysis could serve valuable tool evaluating efficacy therapies, immunotherapy. growing clinical significance calls closer examination components, particularly elements like LINE-1. Despite their importance, role not been thoroughly gauged. We aim address this gap by reviewing current literature on assays, focusing applications diagnostics disease

Language: Английский

Citations

0