A Mathematical Study of Effects of Alzheimer’s Drug Donepezil Hydrochloride on Neuronal Viscoelasticity and Action Potentials DOI Creative Commons
Corina S. Drapaca

Mathematical and Computational Applications, Journal Year: 2024, Volume and Issue: 29(6), P. 117 - 117

Published: Dec. 12, 2024

Alzheimer’s disease (AD) is a degenerative disorder characterized by progressive cognitive decline and memory loss. The few contemporary therapies may ease symptoms and/or slow down AD progression but cannot cure the disease. orally administered drug donepezil hydrochloride enhances availability of acetylcholine that supports cholinergic neurotransmission. In this paper, generalized Hodgkin-Huxley model proposed uses Caputo fractional order temporal derivatives to link action potentials viscoelasticity receptors. provides not only structurally dependent for health also possible mechanism effect on potentials: binding between receptors preserves structural fitness these addition, pharmacokinetic transport brain incorporates controlled release modalities. are used again anomalous release. Numerical simulations show how recovers integrity which further brings abnormal due their healthy state. results suggest combining various modalities dosages improve treatment effectiveness with donepezil.

Language: Английский

Preclinical neuropharmacological effects of Centella asiatica-derived asiaticoside and madecassoside in Alzheimer's disease DOI
Narudol Teerapattarakan, Utcharaporn Kamsrijai, Adchara Janyou

et al.

South African Journal of Botany, Journal Year: 2025, Volume and Issue: 180, P. 171 - 184

Published: March 12, 2025

Citations

0
Venom peptides regulating Ca2+ homeostasis: neuroprotective potential DOI

Jessica A.I. Muller,

Lachlan A. Bourke, Sam I.D. Campbell

et al.

Trends in Pharmacological Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
A Mathematical Study of Effects of Alzheimer’s Drug Donepezil Hydrochloride on Neuronal Viscoelasticity and Action Potentials DOI Creative Commons
Corina S. Drapaca

Mathematical and Computational Applications, Journal Year: 2024, Volume and Issue: 29(6), P. 117 - 117

Published: Dec. 12, 2024

Alzheimer’s disease (AD) is a degenerative disorder characterized by progressive cognitive decline and memory loss. The few contemporary therapies may ease symptoms and/or slow down AD progression but cannot cure the disease. orally administered drug donepezil hydrochloride enhances availability of acetylcholine that supports cholinergic neurotransmission. In this paper, generalized Hodgkin-Huxley model proposed uses Caputo fractional order temporal derivatives to link action potentials viscoelasticity receptors. provides not only structurally dependent for health also possible mechanism effect on potentials: binding between receptors preserves structural fitness these addition, pharmacokinetic transport brain incorporates controlled release modalities. are used again anomalous release. Numerical simulations show how recovers integrity which further brings abnormal due their healthy state. results suggest combining various modalities dosages improve treatment effectiveness with donepezil.

Language: Английский

Citations

0