Synthesis of 4-Hydroxy Coumarin Hybrid with 2H-Thiopyran and Imidazolidine-2,4-Dione Derivatives and the Investigation of their Antimicrobial, Anticoagulant and Cytotoxic Activities, and Molecular Docking DOI

Velmurugan Loganathan,

Arunadevi Mani,

Anis Ahamed

et al.

Chemistry Africa, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 22, 2024

Language: Английский

Vitamin K Properties in Stroke and Alzheimer’s Disease: A Janus Bifrons in Protection and Prevention DOI Creative Commons
Lorenzo Grimaldi,

Rosaria A. Cavallaro,

Domenico De Angelis

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(5), P. 1027 - 1027

Published: Feb. 24, 2025

Vitamin K is essential for many physiological processes, including coagulation, bone metabolism, tissue calcification, and antioxidant activity. vitamers are represented by lipophilic compounds with similar chemical structure (i.e., phylloquinone (vitamin K1) menaquinone K2)). deficiency can affect coagulation vascular increasing the risk of hemorrhages, atherosclerosis, cerebrovascular diseases, neurodegeneration. Recently, several studies have hypothesized a possible dual role vitamin in benefiting both cerebral health, e.g., sphingolipids biosynthesis or ferroptosis inhibition. The aim this narrative review to deepen understanding biological activities its protective/preventive actions neurovascular degenerative conditions, stroke dementia. Given difficulties related hemorrhagic entailed prevention strokes, function antagonists also investigated. Finally, we track development clinical concept future preventive strategy innovative use as supplement counteract pathological focusing particular on

Language: Английский

Citations

0
Introduction to bioactive compounds: Definition, advantages, and limitations DOI
Seid Reza Falsafi, Fuat Topuz, Basheer Aaliya

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 3 - 24

Published: Jan. 1, 2025

Language: Английский

Citations

0
The Protective Role of Vitamin K in Aging and Age-Related Diseases DOI Open Access
Julia Kaźmierczak-Barańska, Bolesław T. Karwowski

Nutrients, Journal Year: 2024, Volume and Issue: 16(24), P. 4341 - 4341

Published: Dec. 16, 2024

Aging is an inevitable aspect of life, but age-related diseases are not inseparable part the aging process, and their risk can be reduced through a healthy lifestyle. Vitamin K has broader impact than just blood clotting, yet it remains overshadowed by other vitamins underestimated both doctors consumers. (VK) multifunctional micronutrient with anti-inflammatory antioxidant properties, whose deficiency may cause such as cardiovascular diseases, neurodegenerative osteoporosis. There growing body evidence supporting role vitamin protective nutrient in inflammation. This review summarizes current knowledge regarding molecular aspects its clinical implications.

Language: Английский

Citations

1
Synthesis of 4-Hydroxy Coumarin Hybrid with 2H-Thiopyran and Imidazolidine-2,4-Dione Derivatives and the Investigation of their Antimicrobial, Anticoagulant and Cytotoxic Activities, and Molecular Docking DOI

Velmurugan Loganathan,

Arunadevi Mani,

Anis Ahamed

et al.

Chemistry Africa, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 22, 2024

Language: Английский

Citations

0