The current landscape of aromatase inhibitors for the treatment of estrogen receptor-positive breast carcinoma

The Journal of Steroid Biochemistry and Molecular Biology, Journal Year: 2025, Volume and Issue: 250, P. 106729 - 106729

Published: March 7, 2025

Language: Английский

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MASLD: Prevalence, Mechanisms, and Sex-Based Therapies in Postmenopausal Women

Biomedicines, Journal Year: 2025, Volume and Issue: 13(4), P. 855 - 855

Published: April 2, 2025

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic influenced by genetic, lifestyle, and environmental factors. While MASLD more prevalent in men, women are at increased risk after menopause, highlighting critical pathogenetic role of sex hormones. The complex interplay between estrogen deficiency, visceral fat accumulation, metabolic syndrome (MetS), inflammation accelerates progression, increases cardiovascular (CV) risk, triggers a cycle worsening adiposity, dysfunction, psychological problems, including eating disorders. Weight loss postmenopausal can significantly improve both outcomes, helping to prevent related conditions. This review examines prevalence MASLD, its comorbidities (type 2 diabetes T2D, CV, mental disorders), mechanisms, pharmacological treatment with GLP-1 receptor agonists (GLP1-RAs), focus on women. Given use GLP1-RAs obesity T2D patients, increase MetS this analyzes potential stable GLP-1–estrogen conjugate as therapeutic approach subgroup. By combining synergistic effects hormones, dual agonist has been shown food intake reward suppression, resulting greater weight improved insulin sensitivity, glucose, lipid metabolism. Therefore, we hypothesize that pharmacotherapy may provide targeted benefits than either hormone alone protecting liver, β-cells, overall health. As these only supported preclinical data, highlights need for future research evaluate confirm mechanisms efficacy clinical settings, particularly

Language: Английский

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Optimizing the treatment for gastroesophageal reflux disease in young people: the role and place of rebamipide

GASTROENTEROLOGY, Journal Year: 2025, Volume and Issue: 59(1), P. 16 - 22

Published: March 25, 2025

Background. Gastroesophageal reflux disease (GERD) is a condition that results from the of acidic stomach contents into esophagus and causes heartburn or regurgitation. One key factors in pathogenesis this disruption protective function physiological antireflux barriers esophageal mucosa. Objective: to evaluate effect rebami­pide on restoration barrier presence erosive non-erosive forms gastroesophageal young patients. Materials methods. Thirty patients with GERD aged 18 45 years were examined. Accor­ding upper endoscopy, two groups formed: group I — 15 individuals II peop­le GERD, not associated H.pylori. The control consisted practically healthy individuals. Both took proton pump inhibitors (PPIs) (pantoprazole) standard doses rebamipide for 30 days. participants examined indicators NO system blood plasma before after treatment: general activity total nitric oxide synthase (gNOS), inducible (iNOS), neuronal (nNOS) endothelial (eNOS) NOS; functional surface epithelial cells mucosa was assessed by level sialic acids glycosaminoglycans. Results. Signs dysfunction manifested significant increase iNOS 2.3 times (p = 0.0048) 2.6 0.007) compared group. eNOS 1.2-fold lower than both 0.0005) 0.0007). nNOS increased 1.6-fold 0.04) but its decreased significantly treatment 0.04). Nitrite (NO₂) levels 2.6-fold higher < 0.0001) 1.8-fold 0.0022) normalization acid glycosaminoglycan PPI + complex 0.0001 p 0.0001, respectively) confirmation restorative functions Conclusions. addition monotherapy had advantages terms correcting contributing reduction inflammatory infiltration layer submucosal base mucosa, epithelium, healing erosions, which has an important role reparative processes Although studies regarding mucosal are limited, mechanisms action indicate potential benefit. data obtained may be guidelines further clinical effectiveness disease.

Language: Английский

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MOLECULAR MECHANISM AND THERAPEUTIC POTENTIAL OF BERBERINE, BAICALEIN, ORIDONIN IN THE TREATMENT OF COLORECTAL CANCER – A REVIEW

Asian Journal of Pharmaceutical and Clinical Research, Journal Year: 2025, Volume and Issue: unknown, P. 31 - 43

Published: April 7, 2025

The aim of this research is to assess the effect berberine and baicalein oridonin (ORI) treatment on colorectal cancer (CRC) cells. examines how these compounds bring about cellular alterations, stop cell cycle progression, trigger death. cancer-fighting agents together with ORI demonstrate strong anticancer properties against CRC tissues through metabolic instability arrest leading apoptosis. affects activation TP53/TCF4 mechanisms which creates endoplasmic reticulum stress then leads higher reactive oxygen species production alongside calcium ion imbalances. retinoid X receptor alpha mechanism performs better than in colon growth inhibition. Berberine suppresses progression its ability influence transforming factor-beta signaling pathway inhibitory action epithelial-mesenchymal transition weakening liver metastasis. altered composition gut microbes reduces tissue tumorigenesis as well total microbial abundance. shows anti-metastatic capabilities by blocking actions matrix metallopeptidase (MMP)-2 MMP-9 enzymes play important roles cells spreading during suppression occurs berberine-mediated G2/M death that results cyclin B1 cdc2 cdc25c protein downregulation. anti-inflammatory agent acts a major element developing tumorous lesions associated colitis. compound speeds up phase role regulating toll-like 4/nuclear factor-kappa B HT-29 regulatory process decrease stems from inflammation while also restricting multiplication.

Language: Английский

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DYNAMICS OF CHANGES IN NITROGEN OXIDE DERIVATIVES IN YOUNG PATIENTS WITH GASTROESOPHAGEAL REFLUX DISEASE

World of Medicine and Biology, Journal Year: 2025, Volume and Issue: 21(91), P. 37 - 37

Published: Jan. 1, 2025

Language: Английский

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Estrogen hindrance escalates inflammation and neurodegeneration in the hippocampal regions of collagen-induced arthritis female Sprague–Dawley rats

Pflügers Archiv - European Journal of Physiology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 21, 2024

Language: Английский

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