Beta-Thalassemia and Male Infertility: Unraveling the Oxidative Stress Connection—An Up-to-Date Review DOI Creative Commons

Christos Roidos,

Christos-Alexandros Batakoias, Evangelos N. Symeonidis

et al.

Diagnostics, Journal Year: 2024, Volume and Issue: 14(24), P. 2789 - 2789

Published: Dec. 12, 2024

Background/Objectives: Beta-thalassemia (BTH), a genetic disorder resulting from beta-globin gene mutations, affects over 1.5 million people globally. The disorder’s multifactorial impact on male fertility, particularly through oxidative stress (OS), warrants focused study. This review examines the mechanisms of OS in TM, its implications for infertility, and potential antioxidant therapies to mitigate fertility challenges. Methods: A non-systematic was conducted using PubMed, Cochrane, Medscape databases, focusing studies beta-thalassemia erectile dysfunction (ED), hormonal alterations, OS. Studies were screened based relevance, language, topic, with 71 articles meeting inclusion criteria after removing duplicates. Results: findings reveal that OS, exacerbated by iron overload regular blood transfusions, is significantly associated impaired sperm quality patients TM. Iron toxicity gonadotropin levels, reduces quality, contributes hypogonadism. Additionally, show promise reducing OS-induced damage, though efficacy limited lack robust clinical trials. Conclusions: plays considerable role infertility among primarily iron-induced damage disruptions. While may offer partial remedy, further research necessary understand OS’s TM develop effective treatments. highlights need personalized approaches improve reproductive outcomes this population.

Language: Английский

Phosphodiesterase Type 5 Inhibitors in Male Reproduction: Molecular Mechanisms and Clinical Implications for Fertility Management DOI Creative Commons
Aris Kaltsas, Fotios Dimitriadis, Athanasios Zachariou

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(2), P. 120 - 120

Published: Jan. 15, 2025

Phosphodiesterases, particularly the type 5 isoform (PDE5), have gained recognition as pivotal regulators of male reproductive physiology, exerting significant influence on testicular function, sperm maturation, and overall fertility potential. Over past several decades, investigations expanded beyond original therapeutic intent PDE5 inhibitors for erectile dysfunction, exploring their broader implications. This narrative review integrates current evidence from in vitro studies, animal models, clinical research to clarify roles PDEs effecting tract, with an emphasis mechanistic pathways underlying cyclic nucleotide signaling, cellular specificity PDE expression, effects Leydig Sertoli cell functions. Although certain findings suggest potential improvements motility, semen parameters, a more favorable biochemical milieu spermatogenesis, inconsistencies study design, limited sample sizes, inadequate long-term data temper definitive conclusions. Addressing these gaps through standardized protocols, larger diverse patient cohorts, explorations biomarkers could pave way incorporating into evidence-based treatment strategies. In future, such targeted approaches may inform individualized regimens, optimize outcomes, refine application part comprehensive management.

Language: Английский

Citations

1
Empirical Treatments for Male Infertility: A Focus on Lifestyle Modifications and Medicines DOI Creative Commons
Aris Kaltsas, Athanasios Zachariou, Fotios Dimitriadis

et al.

Diseases, Journal Year: 2024, Volume and Issue: 12(9), P. 209 - 209

Published: Sept. 11, 2024

Male infertility is a prevalent issue impacting numerous couples worldwide. This review aims to evaluate the effectiveness of empirical therapies for male infertility, focusing on both lifestyle modifications and medical treatments. study provides comprehensive overview interventions aimed at improving fertility outcomes.

Language: Английский

Citations

6
Erectile Dysfunction in Chronic Kidney Disease and Hemodialysis Patients: A State-of-the-Art Review DOI Open Access
Merkourios Kolvatzis, Αpostolos P. Apostolidis, Fotios Dimitriadis

et al.

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Erectile dysfunction (ED) is a prevalent condition that significantly impacts the quality of life and overall well-being affected individuals. This state-of-the-art (SotA) review covers literature published between 2020 2024, focusing on adult patients with chronic kidney disease (CKD) at various stages, including those receiving hemodialysis individuals who have undergone renal transplantation. The pathophysiology ED in CKD multifaceted, involving vascular, neurogenic, hormonal, psychological components are further exacerbated by metabolic hemodynamic alterations associated disease. provides comprehensive analysis current diagnostic approaches, clinical assessment tools, laboratory evaluations, imaging modalities aid identifying underlying causes patients. Pharmacological treatments, particularly phosphodiesterase type 5 (PDE5) inhibitors, remain cornerstone therapy; however, their efficacy safety impairment require careful consideration. Non-pharmacological interventions, such as lifestyle modifications, exercise regimens, support, explored integral holistic management approach. Additionally, advanced therapeutic options, intracavernosal injections, vacuum erection devices, penile prostheses, emerging therapies low-intensity shockwave therapy, stem cell treatment, gene critically reviewed context CKD. also examines bidirectional relationship comorbidities commonly CKD, cardiovascular disease, diabetes mellitus, syndrome. Special emphasis placed impact dialysis transplantation erectile function, highlighting challenges managing these specific patient populations. Moreover, burden ED, coupled stigma sexual health, underscores necessity multidisciplinary approach integrates nephrologists, urologists, psychologists, primary care providers. Despite advancements treatment modalities, limited adherence, stigma, disparities healthcare access persist. Addressing issues requires targeted educational initiatives policy changes to enhance awareness care.

Language: Английский

Citations

0
Predictive value of systemic inflammatory response index in patients with erectile dysfunction on tadalafil unresponsive patients DOI Creative Commons
Resul Sobay

The Aging Male, Journal Year: 2025, Volume and Issue: 28(1)

Published: Feb. 19, 2025

Erectile dysfunction (ED) is a common disorder that significantly impacts quality of life, and phosphodiesterase type 5 inhibitors (PDE5is) such as tadalafil are one the primary treatments. However, some patients remain unresponsive, necessitating further investigation. To investigate association between systemic inflammatory response index (SIRI) unresponsiveness in erectile patients. A total 106 male who applied to Andrology outpatient clinic with ED complaints January June 2024 were included study. Patients started on daily mg therapy, was assessed after month using International Index Function domain (IIEF-EF). SIRI values, calculated neutrophil, monocyte, lymphocyte counts, compared tadalafil-responsive unresponsive groups. Tadalafil observed 48.1% Non-responders had higher mean age(57.44 ± 12.52 vs. 47.22 11.49, p < 0.001), BMI(27.22 3.17 25.85 2.92, = 0.023), values(1.33 0.82 1.02 0.40, 0.016) responders. Multivariate analysis identified age(OR 1,641, 0.001) SIRI(OR 2.420, 0.014) independent predictors failure. ROC curve revealed cutoff 1.03 (AUC 0.617) 69.1% sensitivity 61.2% specificity. Findings suggest inflammation plays key role pathophysiology may impair PDE5i efficacy.

Language: Английский

Citations

0
Impact of sexuality on degenerative diseases DOI

David Anuoluwapo Oyeniran,

Tobiloba Samuel Olajide, Abayomi Oyeyemi Ajagbe͓

et al.

Progress in brain research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Ameliorative Effect of Rauwolfia vomitoria Ethanol Extract on the Erectile Dysfunction Complicated with Coronary Artery Disease: An In-Vivo and Molecular Docking Approach DOI

Hamdalat Folake Muritala,

Ramzi Abdulrahman, Habeebat Adekilekun Oyewusi

et al.

Cell Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

Language: Английский

Citations

0
Therapeutic Challenges of Diabetes Mellitus-Related Erectile Dysfunction and The Potential Therapeutic Role of Medicinal Plants: A Narrative Review DOI Creative Commons
Hao Wang, Hongyuan Chang, Di Sun

et al.

Drug Design Development and Therapy, Journal Year: 2025, Volume and Issue: Volume 19, P. 3209 - 3223

Published: April 1, 2025

Erectile dysfunction (ED) is a common male sexual and can be induced by diabetes mellitus (DM). Diabetes mellitus-induced erectile (DMED) affects various aspects of the patient's quality life, mental well-being, relationship dynamics. Given increasing incidence DM worldwide, DMED expected to increase accordingly. There are more challenges treat compared non-DMED. The efficacy oral phosphodiesterase-5 inhibitors often ineffective in there need search for effective drugs. Medicinal plants such as Eucommia ulmoides Oliv. Leaf, Cordycep militaris have been used treating some experiments. And ingredients from medicinal Icariside II, Panax notoginseng Saponins also shown beneficial improving function animal models DMED. These may act regulating hormone levels, ameliorating oxidative damage, promoting NO/cGMP. We summarize due related complicated pathogenesis limited therapeutic options, while particularly highlight role their

Language: Английский

Citations

0
The Role of Gut Microbiota Dysbiosis in Erectile Dysfunction: From Pathophysiology to Treatment Strategies DOI Creative Commons
Aris Kaltsas, Ilias Giannakodimos,

Eleftheria Markou

et al.

Microorganisms, Journal Year: 2025, Volume and Issue: 13(2), P. 250 - 250

Published: Jan. 23, 2025

Erectile dysfunction (ED) is a prevalent male sexual disorder characterized by the persistent inability to achieve or maintain an erection sufficient for satisfactory performance. While its etiology multifactorial, encompassing vascular, neurological, hormonal, and psychological components, emerging evidence suggests significant role gut microbiota dysbiosis in development. The influences various metabolic, inflammatory, neuropsychological processes critical erectile function. Dysbiosis can lead systemic inflammation, endothelial dysfunction, hormonal imbalances, altered neurotransmitter production, all of which are key factors ED pathogenesis. This narrative review synthesizes current research on association between alterations ED, highlighting specific bacterial taxa implicated through mechanisms involving metabolic disturbances, regulation. explores potential linking including pro-inflammatory cytokines, barrier integrity disruption, disorders, via gut–brain axis, Furthermore, offers promising avenues developing non-invasive biomarkers therapeutic interventions such as probiotics, prebiotics, dietary modifications, fecal transplantation. Future should focus longitudinal studies, mechanistic explorations, clinical trials validate these findings translate them into practice. Understanding interplay function could unveil novel diagnostic pave way innovative treatments targeting microbiota, ultimately improving men’s overall health.

Language: Английский

Citations

0
Potential and Mechanisms of Indigenous Indonesian Medicinal Plants in Treating Sexual Dysfunction: A Systematic Review and Pharmacological Network Overview DOI Creative Commons
Sukardiman Sukardiman, Roihatul Mutiah, Rosita Handayani

et al.

Heliyon, Journal Year: 2025, Volume and Issue: 11(3), P. e42501 - e42501

Published: Feb. 1, 2025

The epidemiology of Erectile Dysfunction (ED) continues to exhibit an increasing trend annually. use synthetic drugs in treating ED often leads undesirable side effects and has limited efficacy. In Indonesia, several indigenous plants have been empirically utilized for remediation. This study aims identify the latest scientific evidence on potential native Indonesian medicinal treatment elucidate underlying molecular mechanisms using a systematic review Pharmacological Network approach. There are 12 most commonly used by ethnic groups Indonesia treat erectile dysfunction as reviewed this study. A search was conducted across three databases (PubMed, Scopus, Springer) without limiting publication years. Article screening performed Preferred Reporting Items Systematic Reviews Meta-Analyses (PRISMA) flowchart. Determination compound target genes carried out GeneCards, while disease were analyzed DisGeNET. topology explored with Cytoscape 3.10, construction Protein-Protein Interaction Networks realized STRING version 12.0. GO KEGG analyses subsequently SRplot. findings indicated that articles met predefined inclusion criteria. pharmacology network analysis demonstrated compounds present Eurycoma longifolia, specifically stigmasterol, eurycomanone, eurycomalactone, 13 associated (ED), which include BCL2, AKT1, SOAT1, PCSK9, ACHE, BDNF-AS, TMX2-CTNND1, GSK3B, LINCO1672, TP53, H19, HIF1A, IL1B. These connected biological steroid hormone biosynthesis, is essential formation testosterone. Therefore, longifolia demonstrates significant development promising phytopharmaceutical candidate sexual dysfunction.

Language: Английский

Citations

0
Hirudin-Based Treatment of Diabetes-Induced Erectile Dysfunction Through Inhibition of the HIF-1α to Regulate RhoA/ROCK Signaling Pathway: An In Vivo Animal Experiment DOI Creative Commons
Longji Sun,

Nianwen Huang,

Chao Yang

et al.

American Journal of Men s Health, Journal Year: 2025, Volume and Issue: 19(1)

Published: Jan. 1, 2025

Diabetes-induced erectile dysfunction (DIED) is a type of refractory which can be clinically treated using the traditional Chinese medicine leech whose main ingredient hirudin. Oxidative stress damage vascular endothelial cells, affect blood circulation, and induce fibrosis smooth muscle cells. This study assessed efficacy hirudin in treating DIED before exploring its potential mechanism action. was induced rats streptozotocin, while experimental apomorphine used to screen for models. The were then divided into four groups: blank control group (NC group), model (M (H an inhibitor (YC group). After 2 weeks, serum levels malondialdehyde (MDA), superoxide dismutase (SOD), nitric oxide (NO) determined. histological features HIF-1α/RhoA/ROCK signaling pathway-related proteins penile corpus cavernosum detected. Erectile function improved H YC groups without significantly affecting body weight glucose levels, with histopathological analysis also showing improvement structure these groups. In addition, expression lower cavernous tissue ( p < .05), NO SOD being higher .05). level MDA decreased this study, only animal experiments conducted investigate regulation Rho/ROCK pathway by HIF-1α. Cellular studies underlying mechanisms are lacking.

Language: Английский

Citations

0