Stem Cell Research & Therapy, Journal Year: 2025, Volume and Issue: 16(1)
Published: Feb. 11, 2025
The self-renewal ability and multipotency of stem cells give them great potential for use in wound healing. Stem cell-derived exosomes, owing to their close biological resemblance parent cells, offer a more efficient, safer, economical approach facilitating cellular communication interactions within different environments. This makes particularly valuable the treatment both acute chronic wounds, such as lacerations, burns, diabetic ulcers. Long non-coding RNAs (lncRNAs) enclosed one leading actors these extracellular microvesicles, through interaction with miRNAs regulation various signaling pathways involved inflammation, angiogenesis, cell proliferation, migration, could heal wounds. Exosome-derived lncRNAs from facilitate matrix remodeling between macrophages fibroblasts. Moreover, alongside regulating expression inflammatory cytokines, controlling reactive oxygen species levels, enhancing autophagic activity, they also modulate immune responses support Regulating genes related by increasing blood supply accelerating delivery essential substances environment, is another effect exosomal derived These can enhance skin healing homeostasis, proliferation differentiation wound-healing process, fibroblast viability migration injury site. Ultimately, exosome-derived novel insights into molecular mechanisms underlying improved They pave way therapeutic strategies, fostering further research better future. Meanwhile, exosomes mesenchymal due exceptional regenerative properties, well have emerged innovative tools review article aims narrate roles focus on cells.
Language: Английский