Triterpenoids from Chios Mastiha Resin Against MASLD—A Molecular Docking Survey DOI Creative Commons
Nаtаsа Мilоsеvic, Maja Milanović, Milica Medic‐Stojanoska

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(1), P. 51 - 51

Published: Jan. 15, 2025

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic without an approved pharmacological approach for its prevention/treatment. Based on modified Delphi process, NAFLD was redefined as metabolic dysfunction-associated steatotic (MASLD) to highlight aspect of pathogenesis. Chios mastiha (Pistacia lentiscus var. Chia, Anacardiaceae) resin demonstrated promising results in MASLD treatment. In this paper, molecular docking applied test 16 compounds from potential ligands receptors GR, LXRα, LXRβ, PPARα PPARγ, MC4R, AMPK, and VEGFR2, whose up- down-regulation interfere with development progression. The observed had moderate high affinity LXR, PPARγ comparison proven ligands, while their PPARα, VEGFR less pronounced. combination active rather than a single molecule may have superior ability control intertwined pathways.

Language: Английский

Triterpenoids from Chios Mastiha Resin Against MASLD—A Molecular Docking Survey DOI Creative Commons
Nаtаsа Мilоsеvic, Maja Milanović, Milica Medic‐Stojanoska

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(1), P. 51 - 51

Published: Jan. 15, 2025

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic without an approved pharmacological approach for its prevention/treatment. Based on modified Delphi process, NAFLD was redefined as metabolic dysfunction-associated steatotic (MASLD) to highlight aspect of pathogenesis. Chios mastiha (Pistacia lentiscus var. Chia, Anacardiaceae) resin demonstrated promising results in MASLD treatment. In this paper, molecular docking applied test 16 compounds from potential ligands receptors GR, LXRα, LXRβ, PPARα PPARγ, MC4R, AMPK, and VEGFR2, whose up- down-regulation interfere with development progression. The observed had moderate high affinity LXR, PPARγ comparison proven ligands, while their PPARα, VEGFR less pronounced. combination active rather than a single molecule may have superior ability control intertwined pathways.

Language: Английский

Citations

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