Extracellular Vesicles in Sport Horses: Potential Biomarkers and Modulators of Exercise Adaptation and Therapeutics DOI Open Access

Dominika Milczek‐Haduch,

Magdalena Żmigrodzka, Olga Witkowska‐Piłaszewicz

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4359 - 4359

Published: May 3, 2025

Significant systemic metabolic benefits result from even a single exercise session by activating multiple and signaling pathways within the organism. Among these mechanisms, extracellular vesicles (EVs) play critical role delivering their molecular cargo to neighboring or distant cells, thereby influencing cellular metabolism function. As research progresses, EVs represent an exciting frontier in science fitness adaptation processes. There is increasing interest understanding physiology of as particles use minimally invasive diagnostic prognostic biomarkers early detection oxidative stress-related abnormalities. They also show potential be used monitoring progress, injury prevention, recovery, may provide insights for personalized training programs. This review examines current physical activity generating exercise-responsive EVs. It highlights applications optimization, not only human athletes but exercising animals such horses. On other hand, it presents difficulties that researchers currently working on this topic encounter due technical limitations.

Language: Английский

THE GROWING POTENTIAL OF EXTRACELLULAR VESICLE RESEARCH IN VETERINARY MEDICINE DOI Creative Commons
Saša Koprivec

Slovenian Veterinary Research, Journal Year: 2025, Volume and Issue: unknown, P. View - View

Published: April 10, 2025

Extracellular vesicles (EVs) are small, information-rich subcellular structures that have attracted considerable attention in the scientific community. Their ubiquitous presence body and their natural role as cellular messengers make them valuable indicators of physiological pathological state cells tissues. Currently, number specific studies on presence, properties EVs all life forms is increasing exponentially. In veterinary medicine, still relatively under-researched, we only recently begun to explore potential. Naraščajoči potencial raziskav zunajceličnih veziklov v veterinarski medicini Zunajcelični vezikli (ZV) so majhne, informacijsko bogate subcelične strukture, ki znanstveni skupnosti pritegnile veliko pozornosti. Zaradi njihove vsesplošne prisotnosti telesu naravne vloge kot prenašalci informacij dragoceni pokazatelji fiziološkega patološkega stanja celic tkiv. V tem trenutku število študij o prisotnosti, lastnostih vlogi ZV vseh oblikah življenja eksponentno narašča. še vedno razmeroma slabo proučeni šele pred kratkim smo začeli bolj natančno raziskovati njihov potencial.

Citations

0

Advancements in Stem Cell Applications for Livestock Research: A Review DOI Creative Commons

Li Shi,

Muhammad Zahoor Khan, Abd Ullah

et al.

Veterinary Sciences, Journal Year: 2025, Volume and Issue: 12(5), P. 397 - 397

Published: April 23, 2025

Stem cells (SCs), distinguished by their capacity for self-renewal and multipotent differentiation, represent a cornerstone of regenerative medicine. These cells, which can be categorized according to differentiation potential developmental origin, have emerged as pivotal elements in both biomedical research veterinary science. In herbivorous species, stem cell applications yielded particularly promising advances across multiple domains, including reproductive biotechnology, tissue engineering regeneration, therapeutic interventions, immunomodulation. This review synthesizes contemporary on biology five economically significant species: bovine, ovine, deer, equine, camelid. Special emphasis is placed isolation methodologies, culture optimization techniques, the molecular mechanisms governing key signaling pathways. The discussion encompasses technical impediments facing ethical framework necessary responsible scientific advancement, with particular attention animal welfare considerations development implementation cell-based technologies.

Language: Английский

Citations

0

Extracellular Vesicles in Sport Horses: Potential Biomarkers and Modulators of Exercise Adaptation and Therapeutics DOI Open Access

Dominika Milczek‐Haduch,

Magdalena Żmigrodzka, Olga Witkowska‐Piłaszewicz

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4359 - 4359

Published: May 3, 2025

Significant systemic metabolic benefits result from even a single exercise session by activating multiple and signaling pathways within the organism. Among these mechanisms, extracellular vesicles (EVs) play critical role delivering their molecular cargo to neighboring or distant cells, thereby influencing cellular metabolism function. As research progresses, EVs represent an exciting frontier in science fitness adaptation processes. There is increasing interest understanding physiology of as particles use minimally invasive diagnostic prognostic biomarkers early detection oxidative stress-related abnormalities. They also show potential be used monitoring progress, injury prevention, recovery, may provide insights for personalized training programs. This review examines current physical activity generating exercise-responsive EVs. It highlights applications optimization, not only human athletes but exercising animals such horses. On other hand, it presents difficulties that researchers currently working on this topic encounter due technical limitations.

Language: Английский

Citations

0