Targeting Aging Skin with GABALAGEN®: A Synergistic Marine Nutricosmetic Ingredient Validated Through Human Randomized Trials DOI Creative Commons
Jimin Hyun,

Kyoung-Min Rheu,

Bae-Jin Lee

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 245 - 245

Published: Feb. 20, 2025

This study introduces GABALAGEN® (GBL), a marine-derived ingredient combining low-molecular-weight fish collagen and gamma-aminobutyric acid (GABA) produced via lactobacillus fermentation. GBL contains approximately 10% GABA, making up 39% of its free amino profile. A 12-week, randomized, double-blind, placebo-controlled trial with 100 adults (aged 35-60) assessed effects on aging skin. Participants consumed 1500 mg/day in jelly form, 94% completing the study. By Week 12, group showed 20% increase skin hydration 15% reduction wrinkle depth. Improvements density elasticity were also observed, no adverse reported. In vitro tests demonstrated strong antioxidant anti-inflammatory effects, including enhanced superoxide dismutase activity reduced pro-inflammatory cytokine expression UVB-irradiated keratinocytes. exemplifies sustainable innovation by upcycling fishery byproducts into high-value materials while addressing stability issues common to seafood-derived products. The fermentation process ensures safety enhances GABA's bioavailability. scalable method aligns circular economic principles global sustainability goals, extending GBL's potential other functional which proved their safety. represents breakthrough nutricosmetics, efficacy, environmental sustainability, industrial innovation.

Language: Английский

Targeting Aging Skin with GABALAGEN®: A Synergistic Marine Nutricosmetic Ingredient Validated Through Human Randomized Trials DOI Creative Commons
Jimin Hyun,

Kyoung-Min Rheu,

Bae-Jin Lee

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 245 - 245

Published: Feb. 20, 2025

This study introduces GABALAGEN® (GBL), a marine-derived ingredient combining low-molecular-weight fish collagen and gamma-aminobutyric acid (GABA) produced via lactobacillus fermentation. GBL contains approximately 10% GABA, making up 39% of its free amino profile. A 12-week, randomized, double-blind, placebo-controlled trial with 100 adults (aged 35-60) assessed effects on aging skin. Participants consumed 1500 mg/day in jelly form, 94% completing the study. By Week 12, group showed 20% increase skin hydration 15% reduction wrinkle depth. Improvements density elasticity were also observed, no adverse reported. In vitro tests demonstrated strong antioxidant anti-inflammatory effects, including enhanced superoxide dismutase activity reduced pro-inflammatory cytokine expression UVB-irradiated keratinocytes. exemplifies sustainable innovation by upcycling fishery byproducts into high-value materials while addressing stability issues common to seafood-derived products. The fermentation process ensures safety enhances GABA's bioavailability. scalable method aligns circular economic principles global sustainability goals, extending GBL's potential other functional which proved their safety. represents breakthrough nutricosmetics, efficacy, environmental sustainability, industrial innovation.

Language: Английский

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