Acridine-Based Chalcone 1C and ABC Transporters DOI Open Access

Ondrej Franko,

Martina Čižmáriková, Martin Kello

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4138 - 4138

Published: April 27, 2025

Chalcones, potential anticancer agents, have shown promise in the suppression of multidrug resistance due to inhibition drug efflux driven by certain adenosine triphosphate (ATP)-binding cassette (ABC) transporters. The gene and protein expression chosen ABC transporters (multidrug 1, ABCB1; resistance-associated ABCC1; breast cancer protein, ABCG2) human colorectal cells (COLO 205 COLO 320, which overexpress active ABCB1) was mainly studied this work under influence a novel synthetic acridine-based chalcone, 1C. While dropped just at 24 h, compound 1C selectively suppressed cell growth greatly lowered ABCB1 levels 320 24, 48, 72 h. It also reduced ABCC1 after 48 Molecular docking ATPase tests show that probably acts as an allosteric modulator ABCB1. galectin-1 (GAL1) Functional on revealed ABCC1/2 be major contributors both. Overall, transiently GAL1 while affecting important functional transporters, mostly lesser extent cells. 320’s absence points possible yet unknown interaction between

Language: Английский

Molecular docking technology drives multidimensional applications of microbial natural products DOI

Chan Zhang,

Qingjie Sun,

Arzugul Ablimit

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 142044 - 142044

Published: March 1, 2025

Language: Английский

Citations

0
The 3C (Cell Culture, Computer Simulation, Clinical Trial) Solution for Optimizing the 3R (Replace, Reduction, Refine) Framework during Preclinical Research Involving Laboratory Animals DOI
Sounak Roy,

Mubeena Parveen,

Asis Bala

et al.

ACS Pharmacology & Translational Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Language: Английский

Citations

0
Acridine-Based Chalcone 1C and ABC Transporters DOI Open Access

Ondrej Franko,

Martina Čižmáriková, Martin Kello

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4138 - 4138

Published: April 27, 2025

Chalcones, potential anticancer agents, have shown promise in the suppression of multidrug resistance due to inhibition drug efflux driven by certain adenosine triphosphate (ATP)-binding cassette (ABC) transporters. The gene and protein expression chosen ABC transporters (multidrug 1, ABCB1; resistance-associated ABCC1; breast cancer protein, ABCG2) human colorectal cells (COLO 205 COLO 320, which overexpress active ABCB1) was mainly studied this work under influence a novel synthetic acridine-based chalcone, 1C. While dropped just at 24 h, compound 1C selectively suppressed cell growth greatly lowered ABCB1 levels 320 24, 48, 72 h. It also reduced ABCC1 after 48 Molecular docking ATPase tests show that probably acts as an allosteric modulator ABCB1. galectin-1 (GAL1) Functional on revealed ABCC1/2 be major contributors both. Overall, transiently GAL1 while affecting important functional transporters, mostly lesser extent cells. 320’s absence points possible yet unknown interaction between

Language: Английский

Citations

0