Galectin-3 in Cardiovascular Health: A Narrative Review Based on Life’s Essential 8 and Life’s Simple 7 Frameworks DOI Creative Commons
Adrian Martuszewski, Patrycja Paluszkiewicz, Rafał Poręba

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(5), P. 332 - 332

Published: May 6, 2025

Gal-3, also known as galectin-3, a lectin that binds β-galactosides, has gained attention novel biomarker and pathophysiological mediator in cardiovascular disease, where it contributes to inflammation, fibrosis, metabolic dysregulation cardiac remodeling. This narrative review, developed following SANRA (Scale for the Assessment of Narrative Review Articles) guidelines, aims integrate current clinical experimental findings on gal-3 into American Heart Association Life’s Simple 7 (LS7) Essential 8 (LE8). By thematically organizing our review across modifiable domains health, including glucose regulation, lipid metabolism, physical activity, blood pressure, diet, sleep, tobacco use, body weight (BMI, mass index), we highlight role linking environmental, behavioral molecular risk factors cardiometabolic outcomes. Particular is given oxidative stress, inflammatory–fibrotic axis, immune activation mechanistic pathways underlying gal-3-associated damage. We discuss its relevance public health prevention, considering gal-3’s potential early stratification, monitoring lifestyle interventions personalized prevention strategies. bridges mechanisms with relevance, particularly context environmental lifestyle-related risk.

Language: Английский

Galectin-3 in Cardiovascular Health: A Narrative Review Based on Life’s Essential 8 and Life’s Simple 7 Frameworks DOI Creative Commons
Adrian Martuszewski, Patrycja Paluszkiewicz, Rafał Poręba

et al.

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(5), P. 332 - 332

Published: May 6, 2025

Gal-3, also known as galectin-3, a lectin that binds β-galactosides, has gained attention novel biomarker and pathophysiological mediator in cardiovascular disease, where it contributes to inflammation, fibrosis, metabolic dysregulation cardiac remodeling. This narrative review, developed following SANRA (Scale for the Assessment of Narrative Review Articles) guidelines, aims integrate current clinical experimental findings on gal-3 into American Heart Association Life’s Simple 7 (LS7) Essential 8 (LE8). By thematically organizing our review across modifiable domains health, including glucose regulation, lipid metabolism, physical activity, blood pressure, diet, sleep, tobacco use, body weight (BMI, mass index), we highlight role linking environmental, behavioral molecular risk factors cardiometabolic outcomes. Particular is given oxidative stress, inflammatory–fibrotic axis, immune activation mechanistic pathways underlying gal-3-associated damage. We discuss its relevance public health prevention, considering gal-3’s potential early stratification, monitoring lifestyle interventions personalized prevention strategies. bridges mechanisms with relevance, particularly context environmental lifestyle-related risk.

Language: Английский

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