Beginning to See the Light: Lessons Learned From the Development of the Circadian System for Optimizing Light Conditions in the Neonatal Intensive Care Unit DOI Creative Commons

Esther M. Hazelhoff,

Jeroen Dudink, Johanna H. Meijer

et al.

Frontiers in Neuroscience, Journal Year: 2021, Volume and Issue: 15

Published: March 18, 2021

The circadian timing system optimizes health by temporally coordinating behavior and physiology. During mammalian gestation, fetal rhythms are synchronized the daily fluctuations in maternal body temperature, hormones nutrients. Circadian disruption during pregnancy is associated with negative effects on developmental outcomes offspring, highlighting importance of regular robust 24-h over gestation. In case preterm birth (before 37 weeks gestation), cues no longer synchronize neonate’s system, which may adversely affect neonate. There increasing evidence that introducing light-dark cycles Neonatal Intensive Care Unit has beneficial clinical infants, such as weight gain hospitalization time, compared to infants exposed constant light or near-darkness. However, biological basis for these relationship functional anatomical development not fully understood. this review, we provide a concise overview neonates NICU its alignment system.

Language: Английский

A Protocol to Determine Circadian Phase by At‐Home Salivary Dim Light Melatonin Onset Assessment DOI Creative Commons
Jade M. Murray, J. Stone, Sabra M. Abbott

et al.

Journal of Pineal Research, Journal Year: 2024, Volume and Issue: 76(5)

Published: Aug. 1, 2024

Internal circadian phase assessment is increasingly acknowledged as a critical clinical tool for the diagnosis, monitoring, and treatment of rhythm sleep-wake disorders investigating timing in other medical disorders. The widespread use in-laboratory assessments routine practice has been limited, most likely because not required by formal diagnostic nosologies, generally covered insurance. At-home salivary dim light melatonin onset (DLMO, validated marker) an accepted approach to assess phase. This may help meet increased demand advantages lower cost greater patient convenience. We reviewed literature describing at-home DLMO methods identified factors deemed be important successful implementation. Here, we provide specific protocol recommendations conducting facilitate standardized research purposes. Key include control lighting, sampling rate, timing, measures compliance. findings from implementation optimization algorithm determine efficient number samples patients with Delayed Sleep-Wake Phase Disorder. also assay interpretation. Providing definitive criteria each factor, along detailed instructions implementation, will enable more adoption diagnostic, tool.

Language: Английский

Citations

9
Preliminary Results: The Impact of Smartphone Use and Short-Wavelength Light during the Evening on Circadian Rhythm, Sleep and Alertness DOI Creative Commons
Christopher Höhn, Sarah Schmid, Christina Plamberger

et al.

Clocks & Sleep, Journal Year: 2021, Volume and Issue: 3(1), P. 66 - 86

Published: Jan. 22, 2021

Smartphone usage strongly increased in the last decade, especially before bedtime. There is growing evidence that short-wavelength light affects hormonal secretion, thermoregulation, sleep and alertness. Whether blue filters can attenuate these negative effects still not clear. Therefore, here, we present preliminary data of 14 male participants (21.93 ± 2.17 years), who spent three nights laboratory, reading 90 min either on a smartphone (1) with or (2) without filter, (3) printed material Subjective sleepiness was decreased during smartphone, but no were evening objective alertness GO/NOGO task. Cortisol elevated morning after which resulted reduced cortisol awakening response. Evening melatonin nightly vasodilation (i.e., distal-proximal skin temperature gradient) material. Early slow wave sleep/activity only filter. These results indicate circadian rhythm causes further physiology morning. Using filter partially reduces effects.

Language: Английский

Citations

48
Effects of Daytime Electric Light Exposure on Human Alertness and Higher Cognitive Functions: A Systematic Review DOI Creative Commons
Mushfiqul Anwar Siraji, Vineetha Kalavally, Alexandre Schaefer

et al.

Frontiers in Psychology, Journal Year: 2022, Volume and Issue: 12

Published: Jan. 5, 2022

This paper reports the results of a systematic review conducted on articles examining effects daytime electric light exposure alertness and higher cognitive functions. For this, we selected 59 quantitative research from 11 online databases. The protocol was registered with PROSPERO (CRD42020157603). showed that both short-wavelength dominant intensity white induced alertness. However, those influences depended factors like participants’ homeostatic sleep drive time day participants received exposure. relationship between functions not as straightforward alerting effect. optimal property for reported dependent other factors, such task complexity properties control light. Among studies exposure, ten (morning: 3; afternoon: 7) beneficial simple performances (reaction time), four 1) complex performances. Four performance nine 5; 4) performance. Short-wavelength effect did hold indicate need further to understand influence illuminance

Language: Английский

Citations

35
Individual differences and diversity in human physiological responses to light DOI Creative Commons
Manuel Spitschan, Nayantara Santhi

EBioMedicine, Journal Year: 2022, Volume and Issue: 75, P. 103640 - 103640

Published: Jan. 1, 2022

Exposure to light affects our physiology and behaviour through a pathway connecting the retina circadian pacemaker in hypothalamus - suprachiasmatic nucleus (SCN). Recent research has identified significant individual differences non-visual effects of light,mediated by this pathway. Here, we discuss fundamentals light. We propose set actions improve evidence database be more diverse: understanding systematic bias base, dedicated efforts recruit diverse participants, routine deposition sharing data, development data standards reporting guidelines.

Language: Английский

Citations

35
Towards a framework for light-dosimetry studies: Methodological considerations DOI
Steffen Hartmeyer,

FS Webler,

Marilyne Andersen

et al.

Lighting Research & Technology, Journal Year: 2022, Volume and Issue: 55(4-5), P. 377 - 399

Published: July 19, 2022

For field research of non-visual effects light, accurate measurement personal light exposure is required. A consensus framework for light-dosimetry could improve and ensure comparability between studies. Here, we present a review methodologies used in studies published to date, focussing on considerations regarding the preparation data. Overall, large variability studies’ observed, highlighting need framework. We propose methodological that should be included such can guide future Furthermore, highlight important points addressed compatibility different dosimetry Taken together, this effort underlines importance systematic approach order harness all power integrative lighting real life.

Language: Английский

Citations

31
Verification, analytical validation and clinical validation (V3) of wearable dosimeters and light loggers DOI
Manuel Spitschan, K.C.H.J. Smolders, Benjamin Vandendriessche

et al.

Digital Health, Journal Year: 2022, Volume and Issue: 8, P. 205520762211448 - 205520762211448

Published: Jan. 1, 2022

Background Light exposure is an important driver and modulator of human physiology, behavior overall health, including the biological clock, sleep-wake cycles, mood alertness. can also be used as a directed intervention, e.g., in form light therapy seasonal affective disorder (SAD), jetlag prevention treatment, or to treat circadian disorders. Recently, system quantities units related physiological effects was standardized by International Commission on Illumination (CIE S 026/E:2018). At same time, biometric monitoring technologies (BioMeTs) capture personalized were developed. However, because there are currently no standard approaches evaluate digital dosimeters, need provide firm framework for characterization, calibration, reporting these sensors urgent. Objective This article provides such applying principles verification, analytic validation clinical (V3) state-of-the-art approach tools standards medicine dosimetry. Results describes opportunities use dosimeters basic research, exposure, measuring adherence both non-clinical populations light-based interventions trials.

Language: Английский

Citations

31
Is there a diurnal variation in 4-km cycling time-trial performance, conducted in an environmental chamber where a standardised approach has been employed? DOI Creative Commons
Ben Edwards,

Chris Harris,

Z. Jackman

et al.

Biological Rhythm Research, Journal Year: 2024, Volume and Issue: 55(2), P. 184 - 209

Published: Feb. 1, 2024

We investigated the hypothesis that a daily-variation exists for 4-km time-trial, where standardised-approach has been employed. Twenty-six male students completed 30-s Wingate test, V˙O2 peak test: and then three familiarisations at 12:00 h. Two further time-trials counterbalanced start 07:30 or 17:30 h were undertaken. There was 72 between each session. Heart rate, rectal skin temperature values, rating-of-perceived-exertion, effort, pacing perception split-times measured every 1-km during time-trial. Blood lactate, urine osmolarity, taken rest immediately after Evening finishing times, resting temperatures, pre-post time-trial blood lactate faster, higher with greater rise (~10 s, 0.48°C, 0.7mmol.L) than morning values (p<0.05) no other interactions. In summary, standardised approach employed performance 2.6 % faster in evening (ES = 0.34, power 0.8).

Language: Английский

Citations

6
Smart Lighting Application for Energy Saving and User Well-Being in the Residential Environment DOI Open Access
Moe Soheilian, Géza Fischl, Mbc Myriam Aries

et al.

Sustainability, Journal Year: 2021, Volume and Issue: 13(11), P. 6198 - 6198

Published: May 31, 2021

The idea of smart lighting has emerged over the years in commercial and industrial environments, with a focus on energy saving. With advancement technology, can now offer opportunities addition to saving users home environments for provision comfortable atmosphere maintenance user well-being. Currently, research field is predominantly dedicated non-residential environments; meanwhile, residential have not been explored. Therefore, literature review was conducted provide an overview systems’ effect well-being environment. Current mostly limited designing developing system controlled environment, evaluation comfort. shows that application possibilities are widely thoroughly

Language: Английский

Citations

35
Melatonin suppression by light involves different retinal photoreceptors in young and older adults DOI Creative Commons
Raymond P. Najjar, Abhishek S. Prayag, Claude Gronfier

et al.

Journal of Pineal Research, Journal Year: 2024, Volume and Issue: 76(1)

Published: Jan. 1, 2024

Abstract Age‐related sleep and circadian rhythm disturbances may be due to altered nonvisual photoreception. Here, we investigated the temporal dynamics of light‐induced melatonin suppression in young older individuals. In a within‐subject design study, participants were exposed for 60 min (0030‐0130 at night) nine narrow‐band lights (range: 420−620 nm). Plasma was calculated 15, 30, 45, time intervals. Individual spectral sensitivity photoreceptor contribution predicted each interval age group. participants, melanopsin solely drove all intervals, with peak 485.3 nm established only after 15 light exposure. Conversely, light‐driven best explained by more complex model combining melanopsin, S‐cone, M‐cone functions, stable (~500 nm) Aging is associated distinct light. While adults melanopsin‐only photoreception reliable predictor suppression, individuals this process jointly driven functions. These findings offer new prospects customizing therapy

Language: Английский

Citations

5
Effects of light on human circadian rhythms, sleep and mood DOI
Christine Blume, Corrado Garbazza, Manuel Spitschan

et al.

Published: May 1, 2019

Humans live in a 24-hour environment, which light and darkness follow diurnal pattern. Our circadian pacemaker, the suprachiasmatic nuclei (SCN) hypothalamus, is entrained to solar day via pathway from retina synchronises our internal biological rhythms. Rhythmic variations ambient illumination impact behaviours such as rest during sleep activity wakefulness well their underlying processes. Rather recently, availability of artificial has substantially changed especially evening night hours. This may increase risk developing rhythm sleep–wake disorders (CRSWD), are often caused by misalignment endogenous rhythms external light–dark cycles. While exact relationship between CRSWD remains be established, nocturnal been shown alter humans. On other hand, can also used an effective noninvasive therapeutic option with little no side effects, improve sleep, mood general well-being. article reviews current state knowledge regarding effects on rhythms, mood.

Language: Английский

Citations

37