Light
exerts
multiple
non-image-forming
biological
effects
on
physiology
including
the
stimulation
of
alertness
and
cognition.
However,
subcortical
circuitry
underlying
stimulating
impact
light
is
not
established
in
humans.
We
used
7
Tesla
functional
magnetic
resonance
imaging
to
assess
variations
illuminance
regional
activity
hypothalamus
while
healthy
young
adults
(N=26;
16
women;
24.3
±
2.9y)
were
completing
two
auditory
cognitive
tasks.
find
that,
during
both
executive
emotional
tasks,
higher
triggered
an
increase
over
posterior
part
hypothalamus,
which
includes
tuberomamillary
nucleus
lateral
hypothalamus.
In
contrast,
increasing
evoked
a
decrease
anterior
ventral
parts
encompassing
notably
suprachiasmatic
another
tuberomammillary
nucleus.
Critically,
performance
task
was
improved
under
negatively
correlated
with
area.
These
findings
reveal
distinct
local
dynamics
different
regions
that
underlie
Communications Biology,
Journal Year:
2023,
Volume and Issue:
6(1)
Published: Sept. 16, 2023
Exposure
to
blue
wavelength
light
stimulates
alertness
and
performance
by
modulating
a
widespread
set
of
task-dependent
cortical
subcortical
areas.
How
affects
the
crosstalk
between
brain
areas
trigger
this
stimulating
effect
is
not
established.
Here
we
record
activity
19
healthy
young
participants
(24.05±2.63;
12
women)
while
they
complete
an
auditory
attentional
task
in
darkness
or
under
active
(blue-enriched)
control
(orange)
light,
ultra-high-field
7
Tesla
MRI
scanner.
We
test
if
modulates
effective
connectivity
area
posterior
associative
thalamus,
encompassing
pulvinar,
intraparietal
sulcus
(IPS),
key
regulation
attention.
find
that
only
blue-enriched
strengthens
connection
from
thalamus
IPS.
To
best
our
knowledge,
results
provide
first
empirical
data
supporting
ongoing
non-visual
cognitive
information
flow
IEEE Internet of Things Journal,
Journal Year:
2024,
Volume and Issue:
11(9), P. 16148 - 16157
Published: Jan. 17, 2024
Light
exposure
is
a
vital
regulator
of
physiology
and
behaviour
in
humans.
However,
monitoring
light
not
included
current
wearable
Internet-of-Things
(IoT)
devices,
only
recently
have
international
standards
defined
α-opic
equivalent
daylight
illuminance
measures
for
how
the
eye
responds
to
light.
This
paper
reports
sensor
node
that
can
be
incorporated
into
IoT
provide
real-world
settings.
We
present
system
design,
electronic
performance
testing,
accuracy
measurements
when
compared
calibrated
spectral
source.
includes
consideration
directional
response
sensor,
comparison
placed
on
different
parts
body,
demonstration
practical
use
over
7
days.
Our
device
operates
3.5
days
between
charges,
with
sampling
period
30
s.
It
has
10
channels
measurement,
range
415–910
nm,
balancing
cost
considerations.
Measured
results
13
devices
show
mean
absolute
error
less
than
0.07
log
lx,
minimum
correlation
0.99.
These
findings
demonstrate
accurate
sensing
feasible,
including
at
wrist
worn
locations.
an
experimental
platform
future
investigations
based
lighting
control.
Light
exerts
multiple
non-image-forming
biological
effects
on
physiology
including
the
stimulation
of
alertness
and
cognition.
However,
subcortical
circuitry
underlying
stimulating
impact
light
is
not
established
in
humans.
We
used
7
Tesla
functional
magnetic
resonance
imaging
to
assess
variations
illuminance
regional
activity
hypothalamus
while
healthy
young
adults
(N=26;
16
women;
24.3
±
2.9y)
were
completing
two
auditory
cognitive
tasks.
find
that,
during
both
executive
emotional
tasks,
higher
triggered
an
increase
over
posterior
part
hypothalamus,
which
includes
tuberomamillary
nucleus
lateral
hypothalamus.
In
contrast,
increasing
evoked
a
decrease
anterior
ventral
parts
encompassing
notably
suprachiasmatic
another
tuberomammillary
nucleus.
Critically,
performance
task
was
improved
under
negatively
correlated
with
area.
These
findings
reveal
distinct
local
dynamics
different
regions
that
underlie
Journal of Sleep Research,
Journal Year:
2023,
Volume and Issue:
33(4)
Published: Oct. 30, 2023
Light
triggers
numerous
non-image-forming,
or
non-visual,
biological
effects.
The
brain
correlates
of
these
non-image-forming
effects
have
been
investigated,
notably
using
magnetic
resonance
imaging
and
short
light
exposures
varying
in
irradiance
spectral
quality.
However,
it
is
not
clear
whether
responses
estimation
may
be
biased
by
having
sequential
blocks,
for
example,
through
a
potential
carryover
effect
one
onto
the
next.
We
reasoned
that
pupil
reflex
was
an
easy
readout
could
used
to
address
this
issue.
characterised
sustained
13-16
healthy
young
individuals
under
during
three
distinct
cognitive
processes
(executive,
emotional
attentional).
conditions
pseudo-randomly
alternated
between
monochromatic
orange
(0.16
melanopic
equivalent
daylight
illuminance
lux)
polychromatic
blue-enriched
white
different
levels
(37,
92,
190
lux).
As
expected,
higher
associated
with
larger
each
domain.
This
result
stable
over
sequence
compared
lower
ones.
Exploratory
frequency-domain
analyses
further
revealed
more
variable
levels.
Importantly,
varied
across
tasks
independently
condition,
pointing
impact
history
and/or
context
on
reflex.
Together,
our
results
emphasise
contribution
adaptation
retinal
photoreceptors
influence
therefore
potentially
their
correlates.
International Journal of Interdisciplinary Telecommunications and Networking,
Journal Year:
2025,
Volume and Issue:
17(1), P. 1 - 23
Published: Jan. 14, 2025
As
brain
diseases
become
more
prevalent,
early
assessment
of
function
is
increasingly
vital.
This
study
introduces
a
piano
sight-reading
data
collection
and
processing
system,
along
with
quantitative
evaluation
method
for
health
based
on
spatiotemporal
dimensions.
The
system
demonstrated
effective
storage
analysis,
speed
ability
scores
improving
over
time.
At
the
highest
difficulty
(D),
right
hand
outperformed
left
in
both
(7%
advantage)
(8.6%
higher
score).
Over
time,
Speed
peaked
at
90
73
right,
while
reached
96
92,
respectively.
showed
high
sensitivity
(92%)
specificity
(90%),
positive
negative
predictive
values
90.2%
91.8%,
confirming
its
reliability
detecting
cognitive
improvement
decline.
These
findings
highlight
potential
musical
training
promotion.
Journal of Anatomy,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 15, 2025
Abstract
Non‐image
forming
(NIF)
pathways,
a
specialized
branch
of
retinal
circuitry,
play
crucial
role
supporting
physiological
and
behavioral
processes,
including
circadian
rhythmicity.
Among
the
NIF
regions,
dorsal
raphe
nucleus
(DRN),
midbrain
serotonergic
cluster
neurons,
is
also
devoted
to
functions.
Despite
indirectly
send
photic
inputs
centers
modulating
their
activities,
little
known
about
organization
retina‐DRN
circuits
in
primate
species.
To
enhance
our
understanding
intrinsic
identify
retinoraphe
innervation
common
marmoset
(
Callithrix
jacchus
),
diurnal
non‐human
model,
we
employed
an
anterograde
tract‐tracing
method
labeling
terminal/fibers
with
cholera
toxin
subunit
B
(CTb)
characterized
morphology
projections.
Our
analysis
revealed
that
sparse
CTb
+
terminals
are
predominantly
located
subdomain
DRN,
displaying
two
morphological
types,
such
as
simple
en
passant
R2‐like
terminals.
This
anatomical
evidence
suggests
phylogenetic
stability
projections
species,
potentially
serving
significant
source
modulation
on
profile
DRN.
However,
functional
significance
models
remains
uncertain.
data
provide
foundation
for
aspect
this
circuitry
primates,
contributing
comprehension
pathways
used
by
functions,
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: June 29, 2024
Abstract
While
light
can
affect
emotional
and
cognitive
processes
of
the
medial
prefrontal
cortex
(mPFC),
no
light-encoding
was
hitherto
identified
in
this
region.
Here,
extracellular
recordings
awake
mice
revealed
that
over
half
studied
mPFC
neurons
showed
photosensitivity,
diminished
by
inhibition
intrinsically
photosensitive
retinal
ganglion
cells
(ipRGCs),
or
upstream
thalamic
perihabenular
nucleus
(PHb).
In
15%
neurons,
firing
rate
changed
monotonically
along
light-intensity
steps
gradients.
These
light-intensity-encoding
comprised
four
types,
two
enhancing
suppressing
their
with
increased
intensity.
Similar
types
were
PHb,
where
they
exhibited
shorter
latency
sensitivity.
Light
suppressed
prelimbic
activity
but
boosted
infralimbic
activity,
mirroring
regions’
contrasting
roles
fear-conditioning,
drug-seeking,
anxiety.
We
posit
photosensitivity
represents
a
substrate
light-susceptible,
mPFC-mediated
functions,
which
could
be
ultimately
as
therapeutical
target
psychiatric
addiction
disorders.
